Combomax
Combomax Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Combomax is a brand name. Its generic name is Tamsulosin + Dutasteride.
Introduction
Tamsulosin and Dutasteride, is a combination medication used to treat benign prostatic hyperplasia (BPH).Tamsulosin is an alpha-adrenergic antagonist, while Dutasteride is a 5-alpha reductase inhibitor. By working together, these two drugs can effectively reduce the size of the prostate and improve urinary flow.Uses
Tamsulosin and Dutasteride is used to treat symptoms of an enlarged prostate (benign prostatic hyperplasia, BPH). These include difficulty with starting or maintaining a steady flow of urine, weak stream, the need to frequently urinate, straining when urinating, and the need to urinate frequently at night. It may also be used in combination with other drugs to reduce the symptoms associated with BPH.Mechanism of Action
Tamsulosin acts by blocking alpha-1 adrenergic receptors. This relaxes the muscles of the bladder neck and the prostate, allowing urine to flow more easily and reducing the symptoms associated with BPH. Dutasteride reduces DHT production in the prostate by inhibiting type 2 5-alpha reductase. This reduces the size of the prostate and improves urinary flow.How Long Does it Take to Work?
Tamsulosin and Dutasteride usually begins to work within a few days of use. However, it may take up to several weeks before the full effect is seen. It is important to continue taking the medication as prescribed even if no immediate effect is seen.Absorption
Tamsulosin and Dutasteride are both readily absorbed in the gastrointestinal tract after oral administration. Maximum plasma concentrations are achieved within 5 hours and 4-5 days, respectively.Route of Elimination
Tamsulosin and Dutasteride are both mainly eliminated by renal excretion.Dosage
Tamsulosin and Dutasteride is available as 0.5mg/0.5mg, 0.4mg/0.5mg, and 0.2mg/0.5mg tablets. The recommended dose is one tablet taken orally once daily, usually with or without food. It is important to take the medication exactly as prescribed by the doctor.Administration
Tamsulosin and Dutasteride should be taken orally with or without food. Swallow the tablets whole; do not chew or crush them. The tablets should not be broken, dissolved, or chewed. Take the medication as prescribed, at the same time each day.Side Effect
Common side effects of Tamsulosin and Dutasteride include nausea, diarrhea, dizziness, headache, blurred vision, insomnia, and weakness. If any of these side effects become severe or do not go away, contact your doctor. Other serious side effects that require medical attention include swelling of the face, throat, and tongue, and difficulty breathing.Toxicity
Tamsulosin and Dutasteride both have a low toxicity, and the chances of serious toxicity are very low. It is important to take the medication as prescribed by the doctor in order to reduce the risk of serious side effects.Precautions
Tamsulosin and Dutasteride should not be used by patients who are taking alpha-blockers or 5-alpha reductase inhibitors. It should also not be used by pregnant women as it may cause birth defects. It should also not be used by individuals with severe liver problems.Interaction
Tamsulosin and Dutasteride may interact with other medications, including other alpha-blockers, anticholinergics, diuretics, and 5-alpha reductase inhibitors. It is important to tell your doctor about all medications you are taking in order to reduce the risk of serious side effects.Drug Interaction
Tamsulosin and Dutasteride may interact with other drugs, including anticoagulants, antifungals, hormonal birth control, HIV medications, and medications for high blood pressure. It is important to tell your doctor about all medications you are taking in order to reduce the risk of serious side effects.Food Interactions
Tamsulosin and Dutasteride can interact with certain foods, including grapefruit and grapefruit juice, which may lead to an increased risk of side effects. It is important to tell your doctor if you are taking any food supplements or herbal remedies.Pregnancy Use
Tamsulosin and Dutasteride should not be used by pregnant women as it may cause birth defects. It is important to tell your doctor immediately if you are pregnant or plan to become pregnant during treatment.Lactation Use
Tamsulosin and Dutasteride should not be used by nursing mothers as it may be excreted in breast milk and cause serious side effects in infants. It is important to tell your doctor if you are nursing before starting treatment.Acute Overdose
If an overdose of Tamsulosin and Dutasteride is suspected, seek immediate medical attention. Symptoms of an overdose may include nausea, vomiting, dizziness, drowsiness, and difficulty breathing.Contraindication
Tamsulosin and Dutasteride should not be used by individuals who are taking alpha-blockers or 5-alpha reductase inhibitors. It should also not be used by pregnant women as it may cause birth defects. It should also not be used by individuals with severe liver problems.Use Direction
Tamsulosin and Dutasteride should be taken as prescribed by your doctor. Take one tablet orally once daily, usually with or without food. Swallow the tablets whole; do not chew or crush them. The tablets should not be broken, dissolved, or chewed. Take the medication at the same time each day.Storage Conditions
Tamsulosin and Dutasteride should be stored at room temperature, away from moisture and heat.Keep it away from children and pets.Volume of Distribution
The volume of distribution of Tamsulosin and Dutasteride is 42-54 L.Half Life
The half-life of Tamsulosin and Dutasteride is 6.5-8.5 hours and 7-8 days, respectively.Clearance
The clearance of Tamsulosin and Dutasteride is 274-429 ml/min and 0.09-0.17 L/hr, respectively.Here you find in details version of Combomax
Some Frequently Asked Questions About Combomax
What is Combomax?
Combomax is a prescription drug used to treat benign prostatic hyperplasia (BPH). It combines two drugs, tamsulosin and dutasteride, which both work to reduce symptoms of BPH such as difficulty starting urination, weak urinary stream, feeling of incomplete bladder emptying, and frequent urination.
What are the side effects of Combomax?
The most common side effects of Combomax are drowsiness, dizziness, problems ejaculating, breast tenderness or enlargement, and blurred vision. Less common side effects can include decreased sex drive, depression, and rash.
Can women take Combomax?
Combomax is generally not recommended for women, as it is not approved for the treatment of BPH in women. Women who are pregnant or who may become pregnant should avoid coming in contact with this drug, as it may cause birth defects.
How does Combomax work?
Combomax works by decreasing the production of a hormone called dihydrotestosterone, which is thought to be a cause of BPH. Dutasteride also works to reduce the size of the enlarged prostate, while Tamsulosin relaxes the muscles that control urination, helping to reduce BPH symptoms.
How long does it take for Combomax to work?
It typically takes a few weeks or even months for Combomax to take effect. It is important to take the medication as prescribed and not to stop taking it even if your symptoms seem to improve.
Who should not take Combomax?
Combomax should not be taken by people with certain medical conditions, such as severe kidney or liver disease, uncontrolled high blood pressure, or who are pregnant or may become pregnant. Women should not take Combomax, as it may cause birth defects.
Can Combomax be taken with other medications?
Combomax may interact with certain other medications, such as other alpha-blockers, medications for erectile dysfunction, or other drugs that can lower blood pressure. It is important to speak with your doctor or pharmacist before taking Combomax with any medications.
What are the common dosages of Combomax?
The usual dosage prescribed is one tablet taken by mouth once a day. Your doctor may adjust your dosage depending on your symptoms and response to treatment. It is important to take Combomax as prescribed, and not to stop taking it even if your symptoms seem to improve.
What is the difference between Tamsulosin and Combomax?
Tamsulosin is an alpha-blocker that is usually prescribed to treat BPH. Combomax is a combination of Tamsulosin and dutasteride, which is a 5-alpha-reductase inhibitor, and is used to treat more severe cases of BPH.
Can Combomax be taken on an empty stomach?
Combomax can be taken on an empty stomach or with food. It is important to take this medication with a full glass of water, and to avoid drinking alcohol while taking Combomax.
Can I take Combomax if I am allergic to sulfa drugs?
Combomax does contain sulfa, so people who are allergic to sulfa drugs should not take this medication. If you have a sulfa allergy, be sure to tell your doctor before taking Combomax.
Is it safe to take Combomax while pregnant?
No, Combomax is not safe to take while pregnant, as it can cause birth defects. Women should avoid coming in contact with this drug if they are pregnant or plan to become pregnant.
What should I do if I miss a dose of Combomax?
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the medication at your regular time. Do not take two doses at once, as this can increase your risk of side effects.
What foods or beverages should I avoid while taking Combomax?
You should avoid drinking alcohol while taking Combomax, as it can increase the risk of side effects. Grapefruit and grapefruit juice should also be avoided while taking this medication, as it can interfere with the way Combomax is metabolized in the body.
Does Combomax cause drowsiness?
Yes, Combomax can cause drowsiness, dizziness, and blurred vision, so it is important to be aware of how it affects you before operating a vehicle or heavy equipment.
Can Combomax cause erectile dysfunction?
Yes, Combomax may cause erectile dysfunction as a side effect. If you are experiencing erectile dysfunction, it is important to talk to your doctor about this side effect and other treatments that may be available.
How long should I take Combomax for?
Your doctor will determine how long you should take Combomax for based on your symptoms and response to treatment. It is important to continue taking your medication as prescribed even if you feel better.
Can Combomax cause weight gain?
Combomax is not known to cause weight gain, but if you experience weight gain while taking this medication, it is important to talk to your doctor.
Can I take Combomax while breastfeeding?
No, Combomax should not be taken while breastfeeding, as it is not known if it will enter the breast milk. If you are breastfeeding, it is important to talk to your doctor before taking this medication.
Can I crush Combomax tablets?
No, you should not crush Combomax tablets. This medication should always be taken as a whole tablet, and never broken, chewed, or crushed.
Does Combomax cause hair loss?
Combomax has been known to cause hair loss in some people. If you experience hair loss while taking this medication, it is important to talk to your doctor about it.
Does Combomax interact with any other drugs?
Yes, Combomax can interact with certain other drugs, such as certain alpha-blockers, medications for erectile dysfunction, or other drugs that can lower blood pressure. It is important to speak with your doctor or pharmacist before taking Combomax with any medications.
Can Combomax cause kidney problems?
Combomax may increase the risk of kidney problems in some people. If you have liver or kidney disease, it is important to talk to your doctor before taking this medication.
What should I do if I experience side effects from Combomax?
If you experience side effects from Combomax, it is important to talk to your doctor. Your doctor may suggest adjusting your dosage or switching to a different medication.
Can I take Combomax while taking other medications?
Combomax may interact with certain other medications, such as other alpha-blockers, medications for erectile dysfunction, or other drugs that can lower blood pressure. It is important to speak with your doctor or pharmacist before taking Combomax with any medications.
Can I stop taking Combomax if I feel better?
No, it is important to take Combomax as prescribed and not to stop taking it even if your symptoms seem to improve. Stopping treatment too early may cause your symptoms to return.
Does Combomax make your urine dark?
Combomax may cause your urine to appear darker due to its color. However, if the dark urine is accompanied by pain, fever, chills, or other unusual symptoms, it is important to talk to your doctor.
Does Combomax cause weight gain?
Combomax is not known to cause weight gain, but if you experience weight gain while taking this medication, it is important to talk to your doctor.
How does Combomax work to treat BPH?
Combomax works by decreasing the production of a hormone called dihydrotestosterone, which is thought to be a cause of BPH. Dutasteride also works to reduce the size of the enlarged prostate, while Tamsulosin relaxes the muscles that control urination, helping to reduce BPH symptoms.
Can I drink alcohol while taking Combomax?
No, you should avoid drinking alcohol while taking Combomax, as it can increase the risk of side effects.
Can I stop taking Combomax if my symptoms go away?
No, it is important to take Combomax as prescribed and not to stop taking it even if your symptoms seem to improve. Stopping treatment too early may cause your symptoms to return.
What should I do if I experience depression while taking Combomax?
If you experience depression while taking Combomax, it is important to talk to your doctor. Your doctor may suggest adjusting your dosage or switching to a different medication.
Can Combomax be taken with food?
Yes, Combomax can be taken with food. It is important to take this medication with a full glass of water, and to avoid drinking alcohol while taking Combomax.
Can I take Combomax if I have high blood pressure?
Yes, Combomax may be taken by people with high blood pressure. However, it may interact with certain other medications used to treat high blood pressure, so it is important to talk to your doctor before taking Combomax.
What is the difference between Combomax and finasteride?
Combomax is a combination of Tamsul