Combipres
Combipres Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Combipres is a brand name. Its generic name is Brimonidine + Timolol.
Introduction
Combipres is a combination medication used to decrease intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension. It is a combination of a beta-blocker (timolol) and an alpha-agonist (brimonidine).Uses
Combipres is used to lower high pressure inside the eye that is caused by glaucoma or other eye conditions. Lowering high pressure helps prevent blindness.Mechanism of Action
Combipres works by decreasing the production of fluid inside the eye, resulting in lower eye pressure. While brimonidine works by decreasing the activity of ciliary processes which decreases the production of aqueters; timolol works by blocking beta receptors in the ciliary processes, thus decreasing the production of aqueous humor.How long does it take to work?
Combipres can take several weeks to reach it peak effectiveness. It is important to continue taking the medication as prescribed, even if you do not notice an immediate change.Absorption
Combipres is rapidly absorbed into the bloodstream when taken orally or when administered topically to the eye.Route of Elimination
Combipres are both eliminated primarily through the urine.Dosage
The dosage of Combipres for adults and children 16 years of age or older is one drop of 0.5%/0.5% ophthalmic solution in the affected eye(s) twice daily. The dosage for pediatric patients (ages 2-16 years) is one drop of 0.2%/0.5% ophthalmic solution in the affected eye(s) twice daily.Administration
Combipres should be administered to the affected eye(s) twice daily, approximately 12 hours apart. After removing the protective cap, the dropper tip should be gently pressed against the inner corner of the eye and held there for one to two minutes before releasing. The dropper should not touch anything as this can cause contamination with bacteria.Side effects
Common side effects of Combipres may include: redness or irritation of the eyes, dry eyes, blurred vision, headache, burning or stinging sensation in the eyes, and eye fatigue.Toxicity
If too much Combipres is taken, it can be toxic. Symptoms of overdose may include dizziness, drowsiness, confusion, stomach pain, vomiting, headache, tremor, and shortness of breath. If any of these symptoms occur, contact your healthcare provider right away.Precaution
Brimonidine should be used with caution in people with a history of eye surgery, severe kidney or liver disease, thyroid problems, asthma, diabetes and heart problems. Timolol should be used with caution in the elderly, people with poor circulation, and those with a history of heart problems.Interaction
The concomitant use of Combipres with other topical ophthalmic medication is not recommended. Additionally, the concomitant use of Combipres with medications that can decrease heart rate or blood pressure can result in increased side effects such as headache, dizziness, and fatigue.Disease Interaction
It is not recommended for use in people with severe inflammation of the eye, narrow angle glaucoma, and in those with known hypersensitivity to Brimonidine or Timolol.Drug Interaction
Combipres should not be used concomitantly with other topical ophthalmic medication or systemic drugs that can decrease heart rate or blood pressure. Additionally, avoid taking Combipres with other medications that contain brimonidine, timolol or other beta blockers.Food Interactions
No food interactions have been reported with the use of Combipres.Pregnancy Use
Combipres is not recommended for use during pregnancy as the safety of the medication has not been established.Lactation Use
It is not recommended for use in breastfeeding women as it may accumulate in the breast milk and cause adverse effects in nursing babies.Acute Overdose
If an overdose occurs, the patient should seek medical attention immediately. Symptoms of overdose may include dizziness, drowsiness, confusion, stomach pain, vomiting, headache, tremor, and shortness of breath.Contraindication
Combipres is contraindicated for use in people with severe inflammation of the eye, narrow angle glaucoma, and in those with known hypersensitivity to Brimonidine or Timolol.Use Directions
Combipres should be administered to the affected eye(s) twice daily, approximately 12 hours apart. After removing the protective cap, the dropper tip should be gently pressed against the inner corner of the eye and held there for one to two minutes before releasing. The dropper should not touch anything as this can cause contamination with bacteria.Storage Conditions
Combipres should be stored at room temperature, away from heat, light, and moisture.Volume of Distribution
Combipres are both highly lipophilic and have a large volume of distribution.Half-life
The half-life of Brimonidine is 2.8 hours, while the half-life of Timolol is 5-7 hours.Clearance
The clearance of Combipres is mainly through the kidneys.Here you find in details version of Combipres
Some Frequently Asked Questions About Combipres
What is Combipres?
Combipres is a combination eye drop used to reduce intraocular pressure in people with glaucoma. It contains a combination of brimonidine tartrate and timolol maleate which are both medications used to treat eye pressure.
How does Combipres work?
Brimonidine and timolol are both medications used to reduce intraocular pressure. Brimonidine is a type of alpha agonist which works by decreasing fluid production in the eye while timolol is a beta blocker which reduces the drainage of fluid from the eye. This combination of medications works by reducing the amount of fluid in the eye, resulting in a decrease in intraocular pressure.
Who should use Combipres?
Combipres is used to reduce intraocular pressure in people with glaucoma. It is not recommended for people who are pregnant, breastfeeding, or have asthma. It is important for people to discuss their medical history with their doctor and to follow all instructions before using this medication.
What are the side effects of Combipres?
The most common side effects of Combipres include burning, stinging, dryness of the eyes, eye redness, and blurred vision. Other side effects may include dizziness, headache, and fatigue. If any serious side effects occur, such as confusion or difficulty breathing, seek medical attention immediately.
When should I use Combipres?
Combipres should be used as directed by your doctor. The usual recommended dosing is 1 drop in each affected eye twice a day. It should be used at the same time each day, about 12 hours apart. Try to use this medication at the same time each day in order to maintain an even level of the medication in the blood.
What should I avoid while using Combipres?
It is important to avoid certain activities while using Combipres. Avoid contact lenses and eye makeup while using this medication, as these can increase the risk of side effects. Also, it is important to avoid driving or operating heavy machinery while using this medication as it can cause drowsiness and blurred vision.
Is there anything I should tell my doctor before using Combipres?
Yes, it is important to tell your doctor about any other medications you are currently taking including prescriptions, over-the-counter medications, vitamins, and supplements as they may interact with Combipres. Additionally, inform your doctor of any medical conditions you have, such as heart disease, asthma, or diabetes as these can affect how this medication affects your body.
Can I use Combipres with other eye drops?
It is not recommended to use multiple eye drops at the same time, as this can increase the risk of side effects. Speak to your doctor before using any additional eye drops while taking Combipres. Your doctor may advise to wait at least 10 minutes between using different eye drops.
Is it safe to use Combipres long-term?
Yes, Combipres is generally safe to use long-term, provided it is taken as directed by your doctor. It is important to discuss any concerns with your doctor and to report any adverse effects that may occur.
What happens if I forget to take a dose of Combipres?
If you forget to take a dose of Combipres, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not use a double dose to make up for a missed dose.
Can Combipres cause vision problems?
Combipres can cause vision problems such as blurred vision, double vision, and halo vision. If you experience any of these vision problems, stop using this medication and inform your doctor right away.
Can I wear contact lenses while using Combipres?
No, it is not recommended to wear contact lenses while using Combipres. This medication can cause vision changes and should be used with caution if wearing contact lenses.
Is Combipres safe for children?
Combipres is not recommended for use in children under the age of 18. Speak to a doctor if your child has been prescribed this medication.
Can I drink alcohol while using Combipres?
It is not recommended to drink alcohol while using Combipres. Alcohol can increase the risk of side effects and can make the medication less effective. Speak to your doctor if you are unsure.
Is Combipres covered by insurance?
It depends on your insurance plan. Check with your insurance provider to find out if Combipres is covered by your plan.
What should I do if I experience an allergic reaction after using Combipres?
If you experience an allergic reaction after using Combipres, such as hives, swelling, rash, difficulty breathing, contact your doctor or seek medical help right away.
Is Combipres safe to use while pregnant or breastfeeding?
Combipres is not recommended for use by pregnant or breastfeeding women. Speak to your doctor if you are pregnant or breastfeeding and need to use this medication.
What will happen if I overdose on Combipres?
If you suspect an overdose, you should seek medical help immediately. Overdosing on Combipres can cause severe side effects and could be life-threatening. Symptoms of an overdose may include drowsiness, confusion, and difficulty breathing.
What should I do if I get the Combipres in my eye?
If you get Combipres in your eye, you should flush your eye with water and contact your doctor right away. Do not use contact lenses until your doctor has recommended to do so.
Is Combipres the same as Latanoprost?
No, Combipres and Latanoprost are different medications. Combipres is a combination eye drop used to reduce intraocular pressure in people with glaucoma while Latanoprost is an eye drop used to reduce high pressure in the eye.
What should I do if I accidentally miss a dose of Combipres?
If you miss a dose of Combipres, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not use a double dose to make up for a missed dose.
Will I still need to go to the eye doctor while I'm taking Combipres?
Yes, it is important to go to the eye doctor for regular check-ups even while taking Combipres to monitor your eye pressure. Your doctor will be able to determine if the medication is working for you.
Is Combipres more effective than Latanoprost?
It is not necessarily more effective than Latanoprost, but it may be more effective for some people. It is important to speak to your doctor about the most effective medication for your eye condition.
Are there any other medications I should not take while using Combipres?
It is important to avoid certain medications while using Combipres. Do not take beta blockers, albuterol, or any other medications that can reduce blood flow to the eye. Speak to your doctor before taking any new medications.
Are there any foods I should avoid when taking Combipres?
It is important to avoid foods high in salt and caffeine when taking Combipres. This can make the medication less effective and can increase the risk of side effects. Speak to your doctor before making any major dietary changes.
Can Combipres cause an increase in eye pressure?
It is possible for Combipres to cause an increase in eye pressure. If you experience an increase in eye pressure, stop using this medication and contact your doctor right away.
Should I wear sunglasses while using Combipres?
Yes, it is important to wear sunglasses when going outside while using Combipres. This can help protect your eyes from the sun and can reduce the risk of side effects from the medication.
What is the most common side effect of Combipres?
The most common side effect of Combipres is burning, stinging, dryness of the eyes, eye redness, and blurred vision. Other side effects may include dizziness, headache, and fatigue.
Should I stop taking Combipres if I experience side effects?
If you experience any serious or persistent side effects after taking Combipres, it is important to contact your doctor right away. Your doctor will be able to advise you on whether to stop taking the medication or adjust your dosage.
What is the best way to store Combipres?
Combipres should be stored at room temperature, away from direct sunlight and heat. Keep the medication out of reach of children and pets. Do not freeze the medication and do not use the product if it has expired.
Can I wear eye makeup while using Combipres?
No, it is not recommended to wear eye makeup while using Combipres. This medication can cause vision changes and should be used with caution if wearing eye makeup.
When should I expect to see results after taking Combipres?
It can take several days to a few weeks to see results after taking Combipres. It is important to use the medication as directed by your doctor to ensure that the medication is working for you.
Can I split the doses of Combipres?
No, it is not recommended to split the doses of Combipres. Take the medication as directed by your doctor and do not change the dose without speaking to your doctor.
Does Combipres have any interactions with other medications?
Yes, Combipres can interact with other medications. It is important to tell your doctor about any other medications you are taking including prescriptions, over-the-counter medications, vitamins, and supplements. These may interact with Combipres and could cause serious side effects.
Can Combipres cause changes in blood pressure?
Yes, Combipres can cause changes in blood pressure. It is important to monitor your blood pressure regularly and inform your doctor if you experience any changes.
Can Combipres cause an increase in heart rate?
Yes, Combipres can cause an increase in heart rate. If you experience an increase in heart rate, contact your doctor right away.
What should I do if I forget to use Combipres one day?
If you forget to use Combipres one day, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not use a double dose to make up for a missed