Clinorel
Clinorel Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Clinorel is a brand name. Its generic name is Sulindac.
Clinorel
Clinorel is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. It is used to reduce inflammation and pain associated with rheumatoid arthritis, ankylosing spondylitis, bursitis, and gout. Clinorel may also be used to relieve pain caused by tension headaches and mild to moderate pain following surgical procedures.
Uses For Clinorel
Clinorel is indicated for the relief of the signs and symptoms of rheumatoid arthritis, ankylosing spondylitis, bursitis, and gout. It can also be used to reduce pain still associated with tension headaches and mild to moderate pain following surgical procedures.
Mechanism Of Action
Clinorel works by blocking the action of cyclooxygenase enzymes, which in turn reduces the production of the prostaglandins that cause inflammation and pain. Clinorel is a prodrug which is converted to sulindac sulfide in the liver by phase I metabolic pathways.
How Long Does It Take To Work?
It may take several days or weeks of taking Clinorel for it to reach its maximum effectiveness. Generally, Clinorel starts to work within a few days and its full effects may be seen within two to four weeks.
Absorption
Clinorel is rapidly and nearly completely absorbed from the gastrointestinal tract.
Route Of Elimination
Clinorel is eliminated mainly via the kidneys, with only a small amount being eliminated in the feces.
Dosage
The recommended adult dosage of Clinorel is 150 mg to 300 mg taken orally twice per day. Dosage should be adjusted as needed depending on the individual's needs. However, the maximum recommended dose is 600 mg per day.
Administration
Clinorel should be taken with food or milk to reduce stomach irritation. It should be taken with a full glass of water and may be taken with or without food. Do not break, crush, or chew the tablet. Do not take more than the recommended dose.
Side Effects
The most common side effects of Clinorel include stomach upset, heartburn, nausea, diarrhea, constipation, headache, mild skin rash, and dizziness.
Toxicity
Clinorel can be toxic when taken in large doses or for a long period of time. Signs of toxicity include dizziness, confusion, nausea, vomiting, abdominal pain, and loss of appetite.
Precaution
Patients with a history of allergies, asthma, kidney, or liver disease should inform their doctor prior to taking Clinorel as it can worsen the symptoms of those conditions. Clinorel should also be avoided in individuals with a history of bleeding disorders as it can increase the risk of bleeding. It is also important to inform your doctor if you are pregnant, breastfeeding, or planning to become pregnant.
Interaction
It is important to inform your doctor and pharmacist of all medications that are being taken in order to avoid potential drug interactions with Clinorel. Clinorel may interact with other NSAIDs, corticosteroids, diuretics, SSRIs, and vasodilators.
Disease Interaction
Clinorel may worsen the symptoms of certain diseases such as asthma, allergies, kidney disease, and liver disease. It is important to inform your doctor of any medical conditions you may have prior to taking Clinorel.
Drug Interaction
Drug interactions may occur when Clinorel is taken with other medications such as anticoagulants, SSRIs, aspirin, and corticosteroids. It is important to inform your doctor and pharmacist of all medications that are being taken in order to avoid potential drug interactions.
Food Interactions
Foods containing high amounts of salicylates such as raisins, apples, wine, and beer should be avoided while taking Clinorel as these foods may increase the risk of stomach irritation.
Pregnancy Use
Clinorel should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is important to inform your doctor if you are pregnant or planning to become pregnant.
Lactation Use
Clinorel should not be used while breastfeeding as it may pass through breast milk and cause harm to the infant.
Acute Overdose
If an overdose of Clinorel is suspected, it is important to seek medical attention immediately. Signs of a Clinorel overdose can include dizziness, nausea, vomiting, and abdominal pain.
Contraindication
Clinorel is contraindicated in patients with a history of allergy, asthma, kidney or liver disease, bleeding disorders, or uncontrolled hypertension.
Use Direction
Clinorel should be taken orally, usually twice a day with food or milk. The dosage should be adjusted according to the individual's needs, but the maximum recommended daily dose is 600 mg.
Storage Condition
Clinorel should be stored at room temperature, away from light and moisture. It should also be kept out of reach of children.
Volume of Distribution
The volume of distribution of Clinorel is approximately 5.2 L/kg.
Half Life
The elimination half-life of Clinorel is between 3 and 4 hours.
Clearance
The clearance of Clinorel is approximately 3.2 L/h/kg.
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Some Frequently Asked Questions About Clinorel
What is Clinorel?
Clinorel is a nonsteroidal anti-inflammatory drug (NSAID) prescribed for treating rheumatoid arthritis, osteoarthritis, acute painful shoulder or other painful conditions.
What Does Clinorel Do?
Clinorel relieves pain and reduces inflammation, which helps decrease stiffness and joint swelling. It is typically used in long-term treatment.
How Should I Take Clinorel?
Clinorel is typically taken twice daily with food, as directed by your doctor. Take the medication exactly as prescribed in order to reduce the risk of stomach upset.
What Are The Possible Side Effects of Clinorel?
Common side effects may include stomach upset, nausea, diarrhea, and heartburn. More serious side effects can include kidney and liver damage, allergies, and blood disorders. Make sure to inform your doctor of any side effects you experience.
What Should I Do If I Miss a Dose of Clinorel?
If you miss a dose of Clinorel, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule.
Can I Drink Alcohol While Taking Clinorel?
Alcohol will increase the risk of stomach upset when taking Clinorel. People taking Clinorel should limit their alcoholic beverages or avoid them altogether.
Can I Take Clinorel With Other Medications?
Before taking Clinorel, tell your doctor about any other medicines, supplements, or vitamins you are taking. Taking Clinorel with certain other medications can increase your risk of side effects.
Is Clinorel Safe During Pregnancy?
Clinorel should be avoided during pregnancy, as it can have serious adverse effects on the fetus. Talk to your doctor if you are taking Clinorel and become pregnant.
What Should I Do If I Experience An Allergic Reaction To Clinorel?
Stop taking Clinorel immediately and seek medical attention if you experience any symptoms of an allergic reaction, such as hives, facial swelling, or breathing difficulties.
Should I Avoid Sun Exposure While Taking Clinorel?
Yes. Clinorel can make your skin more sensitive to sunlight. Use sunscreen and wear protective clothing when outdoors to protect your skin.
What Is The Most Common Reason For Taking Clinorel?
The most common reason for taking Clinorel is to relieve pain and inflammation from various kinds of arthritis, including rheumatoid arthritis, osteoarthritis, and acute painful shoulder.
Is Clinorel Addictive?
No. Clinorel is not habit-forming and is not known to be addictive.
Can I Buy Clinorel Over-the-Counter?
No. Clinorel is a prescription-only medication, and should always be taken under the guidance of a doctor.
What Kind Of Tests Are Required Before Taking Clinorel?
Your doctor may order blood tests or other tests before beginning Clinorel to check for preexisting kidney, liver, or heart problems. Your doctor may also recommend regular blood tests to monitor your condition while taking Clinorel.
What Are The Precautions To Observe While Taking Clinorel?
The most important precaution is to take Clinorel exactly as prescribed. Do not take higher doses or take them more often than recommended. Avoid drinking alcohol while taking Clinorel. Make sure to inform your doctor of any medical conditions, including stomach ulcers, before taking Clinorel.
Does Clinorel Have An Expiration Date?
Yes. Clinorel will expire after the date printed on the package. Make sure to check the expiration date and discard any medication that has expired.
What Happens If I Overdose On Clinorel?
Overdosing on Clinorel can be fatal. If you think you or someone else may have taken an overdose of Clinorel, seek immediate medical attention.
Is Clinorel Affected By Food And Drinks?
Clinorel should be taken with food to reduce its potential for causing stomach upset. Grapefruit and grapefruit juice can interfere with Clinorel so it should be avoided.
Is Clinorel Safe For Children?
No. Clinorel is not approved for use in children and should not be given to a child without the advice of a doctor.
Are There Any Long-Term Effects Of Taking Clinorel?
Long-term use of Clinorel has been linked to gastrointestinal bleeding, ulcers, and kidney or liver damage. Consult with your doctor if you have any concerns about long-term use.
Should I Take Clinorel With Milk?
No. Milk should be avoided when taking Clinorel as it may interfere with the absorption of the medication.
Should I Take Clinorel With Antacids?
No. Antacids should not be taken at the same time as Clinorel as they can interfere with the absorption of the medication.
Can I Take Other Pain Relief Drugs Along With Clinorel?
No. Taking two different types of NSAIDs, including Clinorel, can cause serious side effects. Talk to your doctor before combining Clinorel with other medications.
Is Clinorel Available In Liquid Form?
No. Clinorel is only available in tablet form.
Can I Take Clinorel With Aspirin?
No. Taking Clinorel with aspirin can increase your risk of stomach irritation and gastrointestinal bleeding. Avoid taking other non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, at the same time as Clinorel.
How Long Does Clinorel Take To Work?
Clinorel can start to work within an hour and can continue to work for up to 24 hours. Most people begin to experience relief within the first few days of taking Clinorel, but it may take several weeks for the full effects to be seen.
Can Clinorel Help Reduce Fever?
No. Clinorel does not reduce fever and is not indicated for treating fever. Acetaminophen or ibuprofen may be used to reduce fever.
Will Clinorel Help With Chronic Pain?
Yes. Clinorel can be used to reduce chronic pain associated with arthritis and other conditions.
Is Clinorel A Steroid?
No. Clinorel is not a steroid. It is a nonsteroidal anti-inflammatory drug (NSAID).
Do I Need To Wear Sunscreen While Taking Clinorel?
Yes. Clinorel can make your skin more sensitive to sunlight. Use sunscreen or wear protective clothing when outdoors to protect your skin.
Is It Safe To Take Clinorel For A Long Period Of Time?
Yes. While it is safe to take Clinorel for a long period of time, it is important to speak to your doctor regularly about any side effects you may be experiencing.
Can Clinorel Help With Acute Pain?
Yes. Clinorel is commonly used to relieve acute pain, such as in the shoulder, knee, hip, or other joints.
Should I Take Clinorel With Water?
Yes. Clinorel should be taken with water to reduce its potential for causing stomach upset.
Can I Take Clinorel With Vitamin Supplements?
Yes, however you should speak to your doctor before taking any vitamin supplements, especially if you have any health conditions.
What Are The Possible Interactions With Clinorel?
Clinorel may interact with other drugs or dietary supplements. Make sure to tell your doctor about any drugs or supplements you are taking before taking Clinorel.
What Are The Common Uses Of Clinorel?
Clinorel is used to treat rheumatoid arthritis, osteoarthritis, and acute painful shoulder or other painful conditions, reduce pain and inflammation, and decrease stiffness and joint swelling.
How Long Until Clinorel Reaches Its Full Effectiveness?
Most people begin to feel the effects of Clinorel within the first few days of taking it, although it may take several weeks for the full effects to be seen.
Are There Any Alternatives To Taking Clinorel?
Alternatives to taking Clinorel include other non-steroidal anti-inflammatory drugs (NSAIDs), steroids, and over-the-counter pain relief medications such as acetaminophen or ibuprofen.