Clexane

Clexane Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Clexane is a brand name. Its generic name is Enoxaparin.

Clexane

Clexane is an injectable anticoagulant drug (blood thinner). It is a low molecular weight heparin (LMWH) approved by the U.S. Food and Drug Administration (FDA) for prevention and treatment of thrombosis (blood clotting) and treatment of pulmonary embolism.

Uses For

Clexane is used to treat or prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism). Clexane is also used to prevent DVT after certain orthopedic surgical procedures. In addition, in combination with aspirin, enoxaparin is also used after certain heart attacks (acute coronary syndromes) to prevent additional heart attacks.

Mechanism of Action

Clexane is a low molecular weight heparin (LMWH) that works by suppressing the activity of clotting factors (coagulation) in the blood. By decreasing the activity of clotting factors, the risk of developing dangerous blood clots in the veins and arteries is reduced. The anti-clotting action of enoxaparin begins shortly after the drug is injected.

How Long Does It Take to Work?

Clexane begins to work right away, once it is injected. It reaches peak effect 30 to 60 minutes after it is injected.

Absorption

Clexane is rapidly absorbed after injection and reaches peak plasma concentrations within 30 to 60 minutes.

Route of Elimination

Clexane is eliminated primarily through the urinary system.

Dosage

The usual dose of enoxaparin for adults is 30 mg injected subcutaneously every 12 hours. The dose of enoxaparin may be decreased or increased based on the patient's weight and renal function.

Administration

Clexane should always be administered as an injection under the skin (subcutaneously) in the abdominal wall, thigh, or upper arm.

Side Effects

The most common side effects of enoxaparin include: nausea, vomiting, bleeding, pain at the injection site, and rash.

Toxicity

Clexane is not toxic except in cases of overdose. An overdose of enoxaparin may cause excessive bleeding or thrombosis (blood clots).

Precautions

Clexane should be used with caution in patients with renal impairment or other conditions that might affect its elimination, as well as in patients who are pregnant or breastfeeding.

Interactions

Clexane may interact with other medications, such as warfarin, aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), and some antibiotics. Before taking enoxaparin, patients should provide their healthcare provider with a complete list of all medicines currently being taken.

Disease Interaction

Clexane may increase the risk of bleeding in patients with certain conditions, such as a history of bleeding disorders, active ulcerative colitis, and certain types of gastrointestinal bleeding.

Drug Interactions

Clexane may interact with many other medications, including warfarin, aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), and certain antibiotics. Using enoxaparin with any of these medications may increase the risk of bleeding.

Food Interactions

Clexane is not known to interact with food. Patients taking enoxaparin should follow their doctor's instructions regarding diet.

Pregnancy Use

Clexane should not be used during pregnancy unless clearly indicated. All decisions regarding its use during pregnancy should be made with the advice of a healthcare provider.

Lactation Use

Clexane is not known to be secreted into human milk, but caution should be exercised when it is used in nursing mothers.

Acute Overdose

An acute overdose of enoxaparin may cause excessive bleeding or thrombosis (blood clots). Patients who have taken too much enoxaparin should seek medical attention immediately.

Contraindication

Clexane is contraindicated in patients who are allergic to enoxaparin or any of its components.

Use Direction

Clexane should be used according to the instructions of a doctor or healthcare provider.

Storage Condition

Clexane should be stored at room temperature away from direct sunlight. It should not be frozen or exposed to heat or moisture.

Volume of Distribution

The volume of distribution of enoxaparin is approximately 7.4 L.

Half Life

The half-life of enoxaparin is approximately 4.3 hours.

Clearance

The clearance of enoxaparin is approximately 0.14 L/h.

Here you find in details version of Clexane

Some Frequently Asked Questions About Clexane

What is Clexane?

Clexane is a type of anticoagulant medication. It helps prevent blood clots from forming in the body and can be used to treat certain types of blood vessel damage, such as stroke and heart attack.

What is Clexane used for?

Clexane is used to treat deep vein thrombosis (DVT), which is a type of blood clot in the deep veins of the body, and pulmonary embolism (PE), which is a blockage in the lung caused by a clot that has broken off from another part of the body. It can also be used in surgical settings before or after certain types of surgery to prevent blood clots from forming.

How does Clexane work?

Clexane works by preventing clots from forming by stopping certain clotting factors from forming in the body. It also helps reduce the risk of new clots forming.

Is Clexane an anticoagulant?

Yes, Clexane is an anticoagulant, meaning it helps prevent blood clots from forming. It is used to treat and prevent deep vein thrombosis (DVT) and pulmonary embolism (PE).

How long does it take for Clexane to work?

It usually takes about 30 minutes for Clexane to start working. It will reach its peak effect in about two to four hours.

Are there any side effects of Clexane?

Common side effects of Clexane include bruising, itching, swelling or redness at the injection site, dizziness, and nausea. Less common side effects include blood in the urine, confusion, and rash. If any of these side effects are severe or do not go away, talk to your doctor or pharmacist.

Does Clexane cause bleeding?

Yes, Clexane can cause bleeding. It is important to talk to your doctor or pharmacist about any bleeds that do occur, as they may require medical attention. Talk to your healthcare provider before taking Clexane if you have any history of bleeding, or if you are taking any other medications that increase your risk for bleeding, such as aspirin, ibuprofen, or other blood thinners.

How is Clexane administered?

Clexane is usually administered once a day as an injection underneath your skin (subcutaneously). Your healthcare provider will teach you or a caregiver how to properly give the injection. It is important to follow all instructions to ensure that the injection is given correctly.

Can I take Clexane while pregnant?

It is not recommended to take Clexane while pregnant. Talk to your doctor or pharmacist before taking any medication if you are pregnant or planning to become pregnant.

Can I take Clexane while breastfeeding?

It is not recommended to take Clexane while breastfeeding. Talk to your doctor or pharmacist before taking any medication if you are breastfeeding or planning to breastfeed.

What should I avoid while taking Clexane?

It is important to avoid activities that can increase your risk for bleeding while taking Clexane. It is especially important to avoid activities that can cause serious injuries, such as contact sports or activities that involve tools or machinery. Talk to your doctor or pharmacist about any activities or medications that may increase your risk for bleeding while taking Clexane.

Can I take Clexane with other medications?

It is important to talk to your doctor or pharmacist before taking any medications while taking Clexane, as some medications may interact with Clexane and increase your risk for bleeding. Examples of medications to be aware of include aspirin, ibuprofen, other blood thinners, and certain antibiotics.

What if I miss a dose of Clexane?

If you miss a dose of Clexane, take it as soon as you remember, unless it is more than 12 hours past the time you were supposed to take it. If it is more than 12 hours past the time you were supposed to take it, skip the missed dose and resume your normal dosing schedule. Do not double your dose to make up for the missed one.

What if I overdose on Clexane?

If you think you have taken too much Clexane, call your doctor or poison control center right away. Overdoses of Clexane can lead to severe bleeding, so immediate medical attention is needed.

How long does Clexane stay in your system?

Clexane typically stays in your system for 24 hours after it is administered. It is usually given once a day, so this 24 hour period starts and ends with each new dose. It is important to take your doses at the same time each day to keep your level of anticoagulant medication consistent in your bloodstream.

What should I do if I get a fever while taking Clexane?

If you experience a fever while taking Clexane, contact your doctor or pharmacist as soon as possible. They may need to adjust your dose or change your medication if a fever is present.

Should I avoid alcohol while taking Clexane?

Yes, it is important to avoid alcohol while taking Clexane, as alcohol can increase your risk for bleeding. Talk to your doctor or pharmacist before drinking alcohol or taking any medication while taking Clexane.

Are there any dietary restrictions while taking Clexane?

No, there are no dietary restrictions while taking Clexane. However, it is important to talk to your doctor or pharmacist before taking any medications while taking Clexane, as some medications can interact with Clexane and increase your risk for bleeding.

Is Clexane safe for long-term use?

Yes, Clexane is usually safe for long-term use. Talk to your doctor or pharmacist about any potential side effects and risks associated with long-term use of Clexane.

What should I tell my doctor before taking Clexane?

It is important to tell your doctor about any medical conditions you have, any medications you are currently taking, and any allergies you may have before taking Clexane. This will help your doctor determine if Clexane is the right medication for you.

Can I get a flu shot while taking Clexane?

Yes, it is usually safe to get a flu shot while taking Clexane. However, it is important to talk to your doctor or pharmacist before getting the flu shot, as certain medications may increase your risk for bleeding.

Can I get a tattoo while taking Clexane?

No, it is not recommended to get a tattoo while taking Clexane, as it can increase your risk for bleeding. Talk to your doctor or pharmacist before getting a tattoo or piercing.

Can I donate blood while taking Clexane?

No, it is not recommended to donate blood while taking Clexane, as it can increase your risk for bleeding. Talk to your doctor or pharmacist before donating blood.

What is the difference between Clexane and heparin?

Clexane and heparin are both anticoagulants, meaning they help prevent blood clots from forming. However, Clexane is a low molecular weight heparin, meaning it is smaller and can be given as a once-daily injection underneath the skin, whereas heparin is typically given as an intravenous injection several times a day. Clexane also lasts longer in the body than heparin.

Can I take vitamin supplements while taking Clexane?

It is usually safe to take vitamin supplements while taking Clexane. However, talk to your doctor or pharmacist before taking any supplements, as some may interact with Clexane and increase your risk for bleeding.

Can I have dental work while taking Clexane?

It is usually safe to have dental work while taking Clexane. However, it is important to tell your dentist that you are taking Clexane, as some dental procedures may increase your risk for bleeding.

Can I take over the counter medication while taking Clexane?

It is important to talk to your doctor or pharmacist before taking any over the counter medications while taking Clexane, as some medications may interact with Clexane and increase your risk for bleeding. Examples of medications to be aware of include aspirin, ibuprofen, and anti-inflammatory medications.

Can I take Clexane if I have kidney disease?

Yes, Clexane can be used to treat certain types of blood vessel damage, such as stroke and heart attack, in patients with kidney disease. It is important to talk to your doctor about any kidney problems you may have before taking Clexane, as your dose may need to be adjusted.

Can I take Clexane if I have liver disease?

Yes, Clexane can be used to treat certain types of blood vessel damage, such as stroke and heart attack, in patients with liver disease. It is important to talk to your doctor about any liver problems you may have before taking Clexane, as your dose may need to be adjusted.

Can Clexane cause an allergic reaction?

Yes, Clexane can cause an allergic reaction. Symptoms of an allergic reaction may include itching, rash, hives, swelling, or difficulty breathing. If you experience any of these symptoms, stop taking Clexane and seek medical attention as soon as possible.

Is Clexane approved by the FDA?

Yes, Clexane is approved by the FDA for the treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE).

Should I take Clexane with food?

No, it is not necessary to take Clexane with food. However, it is important to drink plenty of water while taking Clexane to help minimize the risk of side effects.

What if I get pregnant while taking Clexane?

If you become pregnant while taking Clexane, it is important to talk to your doctor right away, as some medications can increase the risk of certain birth defects. It is also important to keep taking your Clexane, as it can help reduce the risk of blood clots that can lead to a miscarriage.

Should I wear a medical alert bracelet while taking Clexane?

Yes, it is recommended to wear a medical alert bracelet while taking Clexane, as it can help inform emergency personnel that you are taking an anticoagulant medication. This can help ensure that you receive the proper medical care.

What is the proper storage of Clexane?

Clexane should be stored in the refrigerator, and kept away from light and heat. Do not freeze Clexane, and do not keep the medication for longer than four weeks after opening.

Can Clexane be split in half?

No, Clexane should not be split in half. The dose should be taken as instructed by your doctor or pharmacist.

Can I take Clexane if I have a history of bleeding?

Yes, you can take Clexane if you have a history of bleeding. However, it is important to talk to your doctor before taking Clexane if you have a history of bleeding, as you may need to be monitored more closely for signs and symptoms of bleeding.

Should I take a blood thinner like Clexane if I have atrial fibrillation?

Yes, it is recommended to take a blood thinner like Clexane if you have