clariscan

clariscan, a brand name for a formulation containing essential Gadoteric acid, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of clariscan, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Gadoteric Acid: Introduction

clariscan is an intravenous (IV) contrast agent used in magnetic resonance imaging (MRI) to help enhance the clarity of the image. It is the only US Food and Drug Administration (FDA) approved IV contrast agent for neuro and musculoskeletal MRI, including joint spaces, ligaments, muscles, and more. clariscan also has the unique ability to visualize bone marrow and aid in the diagnosis of bone and joint pathologies.

Uses For

clariscan can be used in MRI for the following indications:

  • • Visualizing the joint spaces, ligaments, and muscles in the musculoskeletal system
  • • Identifying and diagnosing various bone and joint pathologies
  • • Viewing bone marrow
  • • Enhancing the clarity of the MRI image used to assess MRI features indicating nerve disease or damage

Mechanism of Action

clariscan works by altering the normal interactions of hydrogen atoms in the body. It is a paramagnetic substance and can modify the local magnetic healthy. It also shortens the spin-spin relaxation time, increasing the signal intensity in imaging, resulting in improved image detail and contrast.

How Long Does it Take to Work?

clariscan can typically be seen on MRI scans within 1-3 minutes. However, the presence and amount of contrast seen on the MRI scan can depend on a variety of factors, including the type of scan being conducted, the dose of gadoteric acid used, and other factors.

Absorption

clariscan is administered intravenously (IV) and is rapidly absorbed in the systemic circulation. It quickly enters the target tissues and is then quickly eliminated from the body.

Route of Elimination

clariscan is rapidly eliminated from the body. It is mostly excreted in the urine, with a relatively small amount excreted in the feces.

Dosage

The dose of gadoteric acid used for imaging varies depending on factors such as patient weight, and the type and level of imaging being conducted. The recommended dose is usually between 0.1-0.2mL/kg (0.088-0.176mL/pound).

Administration

clariscan is administered intravenously, typically as a bolus (single dose). It is important to use an infusion pump when administering gadoteric acid to ensure the correct dose is given over the correct time.

Side Effect

The most common side effects associated with the use of gadoteric acid include: headache, nausea, vomiting, flushing, itching, rash, and hives. These side effects usually resolve on their own and do not require medical intervention. In rare cases, more serious side effects such as difficulty breathing, dizziness, or heart palpitations may occur.

Toxicity

clariscan is generally considered to be safe and well-tolerated, although adverse reactions can occur. The risk of toxicity is low, however, cases of rare reactions have been reported. Therefore, it is important to inform your doctor about any prior allergies or medical conditions prior to receiving gadoteric acid.

Precaution

clariscan should not be used in patients with known hypersensitivity or allergies to the compound. Additionally, gadoteric acid should not be used in patients with renal impairment, liver disease, or heart disease.

Interaction

clariscan should not be used in conjunction with other gadolinium-based IV contrast agents. In addition, gadoteric acid should not be used with certain medications such as anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs), and radiographic dye.

Disease Interaction

clariscan should not be used in patients with any of the following medical conditions: kidney disease, liver disease, heart disease, or a history of stroke. Additionally, it should not be used in patients with a history of allergic reaction to gadolinium-based IV contrast agents.

Drug Interaction

Certain medications can interact with gadoteric acid and should be avoided prior to its use. These medications include anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs), and radiographic dye. It is important to inform your doctor of all the medications, vitamins, and supplements you are taking prior to receiving gadoteric acid.

Food Interactions

No interaction between food and gadoteric acid has been reported or is anticipated. Therefore, it is safe to consume food prior to receiving gadoteric acid. However, it is recommended to avoid eating a heavy meal prior to receiving gadoteric acid.

Pregnancy Use

clariscan is not recommended for use in pregnant women due to the risk of potential harm to the fetus. It is important to inform your doctor immediately if you are pregnant or think you may be pregnant.

Lactation Use

clariscan is not recommended for use in lactating women. It is important to inform your doctor immediately if you are breastfeeding or plan to breastfeed.

Acute Overdose

An overdose of gadoteric acid can cause severe side effects, and it is important to seek medical attention immediately if you think you may have received an overdose of gadoteric acid. Symptoms of an overdose may include nausea, vomiting, headache, flushing, and hives.

Contraindication

clariscan is contraindicated in patients with known allergies or hypersensitivity to it, as well as those with kidney, liver, or heart disease. It should also not be used in conjunction with other gadolinium-based IV contrast agents, anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs), or radiographic dye.

Use Direction

clariscan should be administered by a healthcare professional in accordance with the manufacturer’s instructions. It is important to use an infusion pump when administering gadoteric acid to ensure the correct dose is given over the correct time.

Storage Condition

clariscan should be stored at room temperature and protected from light. It should not be exposed to freezing temperatures or excessive moisture and should be discarded after 30 days if not used.

Volume of Distribution

clariscan has a volume of distribution of 32.6 L. This means that it is evenly distributed throughout the body in a volume (approximately) 32.6 times greater than its total body water.

Half-Life

The half-life of gadoteric acid is approximately 1.06 hours. This means that it is eliminated from the body in approximately 1.06 hours.

Clearance

clariscan has a clearance rate of 1.4 mL/min/kg. This means that it is eliminated from the body at a rate of approximately 1.4 milliliters per minute per kilogram of body weight.

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