Cetirizinum

Cetirizinum, a brand name for a formulation containing essential Cetirizine, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Cetirizinum, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Introduction

Cetirizinum is an antihistamine used to treat a range of allergic reactions, including seasonal allergies (hay fever) and hives. It belongs to a drug class called selective histamine receptor blockers which works by blocking certain natural substances that cause allergy symptoms. Cetirizinum is available in over the counter (OTC) and prescription forms.

Uses for Cetirizinum

Cetirizinum is used to treat allergies in adults and children. It is also used to treat chronic hives and itching due to certain skin conditions. It can be used to prevent and treat sneezing, runny nose, and itchy, watery eyes caused by allergies.

Mechanism of Action

Cetirizinum works by blocking histamine receptors. Histamine is a neurotransmitter that is released when the body is exposed to an allergen, such as pollen or dust. When histamine binds to these receptors, it causes allergy symptoms. By blocking these receptors, cetirizine helps to reduce allergy symptoms.

How Long Does It Take to Work?

Cetirizinum begins to work within 30 minutes of taking it orally. The peak effect occurs in about three hours and it can help to relieve allergy symptoms for up to 24 hours. It can also take several weeks of regular use to experience the full benefits.

Absorption

Cetirizinum is rapidly and almost completely (95%) absorbed when taken orally. After oral administration, it has a mean peak plasma concentration of 1-2 mg/L in 1-1.5 hours.

Route of Elimination

Cetirizinum is primarily renally eliminated, with a mean plasma half-life of 6 hours. Total clearance is approximately 17–19 mL/min/kg.

Dosage

The usual dose of cetirizine for adults and children 12 years of age and older is 10 mg once daily.

For children ages 6 to 11, the recommended dose is 5 mg once daily. For children between the ages of 2 to 5, the recommended dose is 2.5 mg once daily. It is not recommended for children under the age of 2.

Cetirizinum can be taken with or without food. In general, taking it with food can help reduce stomach upset.

Administration

Cetirizinum is available in tablet, syrup, and chewable tablet forms. For adults and children 12 years of age and older, the usual dose is 10 mg once daily. For children ages 6 to 11, the usual dose is 5 mg once daily. For children ages 2 to 5, the usual dose is 2.5 mg once daily. It is not recommended for children under the age of 2.

Cetirizinum tablets should be swallowed whole with a full glass of water. The chewable tablets should be chewed before swallowing. The syrup should be taken directly, without dilution.

Side Effects

Common side effects of cetirizine include drowsiness, dry mouth, nausea, diarrhea, fatigue, and headache. If these side effects persist or become severe, contact your doctor. Rare but serious side effects can occur, including anaphylaxis, urinary retention, and angioedema.

Toxicity

Cetirizinum overdose can produce serious symptoms such as blurred vision, confusion, drowsiness, nausea, vomiting, and decreased coordination. If overdose is suspected, contact your local poison control center or emergency room immediately.

Precautions

Before taking cetirizine, tell your doctor or pharmacist about all of your medical conditions, including if you have glaucoma, difficulty urinating, kidney or liver problems, are pregnant or planning to become pregnant, or are breast-feeding.

Interactions

There may be a drug-drug interaction with other medications. Before administering cetirizine, tell your doctor or pharmacist about all medications you are currently taking, including over-the-counter (OTC) and prescription medications.

Disease Interactions

Cetirizinum should be used with caution in people with kidney or liver disease, as well as those with breathing problems or a history of suicidal thoughts. Be sure to tell your doctor if you have any of these conditions or any other medical condition.

Drug Interactions

Cetirizinum may interact with certain prescription drugs, such as alprazolam, carbamazepine, mexiletine, and warfarin, as well as with alcohol and herbal products. Be sure to tell your doctor about all medications you are currently taking, including over-the-counter (OTC) and prescription medications.

Food Interactions

Cetirizinum is not known to interact with food. However, it is always a good idea to tell your doctor or pharmacist about any medications you are taking and about any foods or beverages you consume.

Pregnancy Use

Cetirizinum should only be used if the potential benefit justifies the potential risk to the fetus. Tell your doctor if you are pregnant or plan to become pregnant before using this medication.

Lactation Use

Cetirizinum is secreted in human milk. It should be used only if the potential benefit justifies the potential risk to the infant. Tell your doctor if you are breastfeeding or plan to breastfeed before using this medication.

Acute Overdose

An overdose of cetirizine can cause serious symptoms such as blurred vision, confusion, drowsiness, nausea, vomiting, and decreased coordination. If you suspect an overdose, contact your local poison control center or emergency room immediately.

Contraindication

Cetirizinum is contraindicated in people with a known hypersensitivity or allergy to cetirizine or any of its ingredients.

Use Direction

Always follow the instructions on the package and use only as directed. Do not take more than the recommended dose and contact your doctor if you have any questions or concerns.

Storage Condition

Store cetirizine at room temperature between 59°F and 86°F (15°C and 30°C). Keep this medication in a tightly closed container and away from heat, light, and moisture.

Volume of Distribution

The steady-state volume of distribution of cetirizine is 31.8 liters.

Half Life

The average plasma half-life of cetirizine is 6 hours.

Clearance

Total clearance of cetirizine is approximately 17–19 mL/min/kg.

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