Celox-R

Celox-R Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Celox-R is a brand name. Its generic name is Celecoxib.

Introduction

Celox-R, also known as Celebrex, is an NSAID medication used to treat various conditions of inflammation and pain. Commonly used to treat arthritis, Celox-R works by inhibiting the enzyme COX-2, reducing inflammation and decreasing pain.

Uses

Celox-R is commonly used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain, menstrual pain, and pain caused by inflammation (such as that associated with injuries). It is also used to reduce the number of colorectal polyps in people with familial adenomatous polyposis.

Mechanism of Action

Celox-R works by inhibiting the COX-2 enzyme, which is responsible for the production of several pro-inflammatory mediators in the body. By blocking the action of this enzyme, the amount of these mediators is reduced, leading to decreased inflammation and pain.

How Long Does It Take to Work?

The effects of Celox-R usually begin within 3-4 days of taking the medication. It may take up to two weeks to feel the full effects of the medication.

Absorption

Celox-R is rapidly and extensively absorbed from the gastrointestinal tract after oral administration.

Route of Elimination

Celox-R is eliminated in the feces and urine. About 80% of an administered dose is recovered in feces as unchanged drug, metabolites, and biliary excretion products. About 30% of the drug is eliminated unchanged in the urine.

Dosage

The recommended adult dose for Celox-R is 200-400 mg taken twice daily. The maximum daily dose is 800 mg. Dosage should be adjusted in patients with impaired kidney function.

Administration

Celox-R should be taken with a full glass of water and should be taken on an empty stomach.

Side Effects

Common side effects of Celox-R include nausea, stomach pain, diarrhea, dizziness, constipation, gas, heartburn, drowsiness, headache, and rash. Some serious side effects may include swelling of the face, hands, feet, ankles, stomach pains, chest pain, and difficulty breathing.

Toxicity

Celox-R is generally well tolerated. However, Celox-R can cause serious side effects if taken in high doses and when used for long periods of time. The risk of serious side effects increases with the duration of treatment.

Precautions

Patients taking Celox-R should be aware of the potential risk for stomach ulcers and bleeding. Patients should also be aware of the risk of hypersensitivity reactions and kidney impairment associated with this medication.

Interaction

Celox-R can interact with other medications, including inhibitors of cytochrome P-450 isoenzymes, antibiotics, antifungals, antihypertensives, anticonvulsants, and some corticosteroids. Before using Celox-R, consult your doctor or pharmacist.

Disease Interaction

Patients with heart failure, high blood pressure, blood clotting disorders, or an allergy to NSAIDs should not take Celox-R. Patients with a pre-existing bleeding disorder, bleeding ulcer, or liver disease should use Celox-R with caution.

Drug Interactions

Celox-R may interact with a number of drugs, including warfarin, lithium, methotrexate, ACE inhibitors, and corticosteroids. Consult your doctor or pharmacist for a complete list of drug interactions.

Food Interactions

Alcohol should be avoided while taking Celox-R. Other foods high in fat may increase the rate of absorption of the medication.

Pregnancy Use

Celox-R is contraindicated in pregnant women. Other NSAIDs should be considered in pregnant women to avoid risk.

Lactation Use

Celox-R is contraindicated in breastfeeding women. Other NSAIDs should be considered in breastfeeding women to avoid risk.

Acute Overdose

In case of acute overdose, seek medical attention immediately. Symptoms may include confusion, vomiting, rash, stomach pain, and breathing difficulty.

Contraindication

Celox-R is contraindicated in pregnant women and breastfeeding women. Celox-R is also contraindicated in patients with a history of hypersensitivity reaction to Celox-R or any other NSAID.

Use Direction

Celox-R should be taken as directed by your health care provider. It should be taken with a full glass of water, and should be taken on an empty stomach. Do not exceed the recommended dosage.

Storage Condition

Celox-R should be stored at room temperature away from direct sunlight and heat. Keep out of reach of children.

Volume of Distribution

The average volume of distribution for Celox-R is approximately 17 L/kg.

Half Life

The average half-life of Celox-R is approximately 11 hours.

Clearance

The clearance for Celox-R is approximately 0.4 L/hr/kg.

Here you find in details version of Celox-R

Some Frequently Asked Questions About Celox-R

What is Celox-R?

Celox-R is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, inflammation, and stiffness caused by arthritis and some other conditions. It is sold under the brand names Celebrex and Celebra.

How does Celox-R work?

Celox-R is an anti-inflammatory drug that works by inhibiting the production of prostaglandins, substances that cause inflammation. This reduction in prostaglandins helps reduce pain and inflammation in patients with arthritis and other conditions.

What is the difference between Celox-R and other NSAIDs?

Celox-R is a newer generation of NSAIDs that are less likely to cause stomach irritation and bleeding. It is also less likely to cause kidney damage than traditional NSAIDs. It is commonly used for the treatment of arthritis and other painful conditions.

What are the side effects of Celox-R?

Common side effects of Celox-R include stomach upset, nausea, diarrhea, headache, and dizziness. Less common but more serious side effects include liver and kidney damage, increased risk of bleeding or stroke, and allergic reactions.

Is Celox-R safe to use long-term?

Celox-R is generally considered safe to use long-term, however it can increase risk of certain side effects such as stomach irritation and an increased risk of stroke or bleeding. Talk to your doctor to make sure Celox-R is right for you.

Can Celox-R be crushed or split in half?

No, Celox-R should not be crushed or split in half. Taking the whole capsule at once is the only safe way to take this medication.

What should be avoided while taking Celox-R?

Alcohol should be avoided while taking Celox-R, as it can increase the risk of stomach bleeding. You should also avoid using other medications including NSAIDs and steroids without talking to your doctor first, as they can increase the risk of side effects.

Is Celox-R safe to use during pregnancy and breastfeeding?

No, Celox-R should not be used during pregnancy or breastfeeding. If you are pregnant or think you might be pregnant, talk to your doctor before taking celecoxib.

Can Celox-R interact with other medications?

Yes, Celox-R can interact with other medications including NSAIDs, steroids, blood thinners, and some antibiotics. Talk to your doctor or pharmacist before starting or changing medications to make sure Celox-R is right for you.

How do you take Celox-R?

Celox-R should be taken exactly as your doctor or healthcare provider has prescribed. Do not take more or less than what is recommended. The usual recommended dose is 200 mg once or twice daily. It should be taken with food to reduce stomach irritation.

What should I do if I miss a dose of Celox-R?

If you miss a dose of Celox-R, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time.

How long does it take for Celox-R to start working?

It can take up to a few weeks for Celox-R to start working. If your symptoms do not improve after 4-6 weeks, talk to your doctor, as the dose may need to be adjusted.

Is Celox-R habit forming?

No, Celox-R is not habit forming. However, it is important to take the medication as prescribed and not to stop taking it without talking to your doctor first.

Is Celox-R safe to use in children?

Celox-R is not approved for use in children. Talk to your doctor before giving your child Celox-R.

Can Celox-R cause weight gain?

No, Celox-R does not typically cause weight gain, however some patients taking this medication may experience appetite changes. Talk to your doctor if you experience significant weight gain while taking Celox-R.

Should I take Celox-R with food?

Yes, Celox-R should be taken with food to reduce stomach irritation. Eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

Is Celox-R addictive?

No, Celox-R is not an addictive medication. However, it is important to take it as prescribed and not to stop taking it without talking to your doctor first.

Can Celox-R cause liver damage?

Yes, there is a risk of liver damage with long-term use of Celox-R. Your doctor may order regular blood tests to monitor your liver function if you take this medication for an extended period of time.

Can Celox-R be used for pain relief?

Yes, Celox-R is often used to treat pain and inflammation associated with arthritis and other conditions. Talk to your doctor to make sure Celox-R is right for you.

Should Celox-R be taken with other medications?

Celox-R can interact with many other medications. Talk to your doctor or pharmacist before starting or changing medications to make sure Celox-R is right for you.

Does Celox-R interact with birth control?

Yes, there is a potential for Celox-R to interact with birth control pills, leading to an increased risk of side effects. Talk to your doctor about safer alternatives for contraception if you take this medication.

Can Celox-R cause stomach pain?

Yes, some patients taking Celox-R may experience stomach pain. Taking the medication with food and eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

Can Celox-R cause drowsiness?

Yes, drowsiness is a possible side effect of Celox-R. Talk to your doctor if you experience excessive drowsiness while taking this medication.

Can Celox-R cause erectile dysfunction?

Yes, erectile dysfunction is a possible side effect of Celox-R. Talk to your doctor immediately if you experience any changes in your sexual function while taking this medication.

Can I take Celox-R and ibuprofen together?

No, taking both Celox-R and ibuprofen at the same time can increase your risk of stomach irritation and bleeding. Make sure to tell your doctor if you are already taking any other medications.

Should I take Celox-R with food or on an empty stomach?

Celox-R should be taken with food to reduce stomach irritation. Eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

Does Celox-R cause hair loss?

No, hair loss is not a common side effect of Celox-R. Talk to your doctor right away if you experience any changes in your hair while taking this medication.

Can Celox-R cause an allergic reaction?

Yes, allergic reactions to Celox-R are possible. Symptoms of an allergic reaction can include rash, itching, difficulty breathing, and swelling. Contact your doctor immediately if you experience any of these symptoms while taking this medication.

Can Celox-R cause constipation?

Yes, constipation is a possible side effect of Celox-R. If you experience constipation while taking this medication, talk to your doctor about ways to manage it.

Can Celox-R be used to treat fever?

No, Celox-R is not typically used to treat fever. Talk to your doctor about other options for treating fever.

Is Celox-R a blood thinner?

No, Celox-R is not a blood thinner. However, it can increase your risk of bleeding when taken with other blood thinning medications. Talk to your doctor before taking Celox-R with other medications.

Can Celox-R cause nausea?

Yes, nausea is a possible side effect of Celox-R. Talk to your doctor if you experience nausea while taking this medication.

Can Celox-R cause dehydration?

Yes, dehydration is a possible side effect of Celox-R. Make sure to drink plenty of fluids while taking this medication, especially if you are experiencing other symptoms such as nausea, vomiting, and diarrhea.

Can Celox-R cause stomach upset?

Yes, stomach upset is a possible side effect of Celox-R. Taking the medication with food and eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

What is the maximum daily dose of Celox-R?

The maximum recommended daily dose of Celox-R is 400 mg. Taking more than this can increase your risk of side effects. Talk to your doctor if you are prescribed a higher dose.

How long can I take Celox-R?

The maximum recommended duration of use of Celox-R is six months. Talk to your doctor if you need to take this medication for longer than this, as it can increase your risk of side effects.

Does Celox-R cause dizziness?

Yes, dizziness is a common side effect of Celox-R. If you experience dizziness while taking this medication, talk to your doctor about ways to manage it.

Should I take Celox-R with food or milk?

Celox-R should be taken with food to reduce stomach irritation. Eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

Does Celox-R reduce inflammation?

Yes, Celox-R is an anti-inflammatory drug that helps reduce inflammation by inhibiting the production of prostaglandins. This can reduce pain and inflammation in patients with arthritis and other conditions.

Does Celox-R cause weight gain?

No, weight gain is not typically caused by Celox-R. However, some patients taking this medication may experience appetite changes. Talk to your doctor if you experience significant weight gain while taking Celox-R.

Can Celox-R cause fatigue?

Yes, fatigue is a possible side effect of Celox-R. Talk to your doctor if you experience fatigue while taking this medication.

Can Celox-R cause heartburn?

Yes, heartburn is a possible side effect of Celox-R. Taking the medication with food and eating a full meal—including protein, vegetables, and some fat—will help protect your stomach.

Do I need to have regular blood tests while taking Celox-R?

Your doctor may order regular blood tests to monitor your liver function if you take this medication for an extended period of time. Talk to your doctor about any other tests you may need while using Celox-R.