Callate
Callate Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Callate is a brand name. Its generic name is Calcium Lactate.
Callate Introduction
Calcium lactate is an inorganic salt composed of two molecules of lactate (CH3CH(OH)COO–) and one calcium cation (Ca2+) which when dissolved in water will form an alkaline solution. Calcium lactate is a tasteless white powder that is odourless and highly soluble in water, making it widely used in many industries.
Uses for
Calcium lactate is most commonly used as a dietary supplement, either in the form of tablets or as a liquid additive to food or beverage. It is also used as a biochemical reagent, buffer, and electrolyte. Calcium lactate has preservative properties and is used as a food additive in cheese and pastries. Calcium lactate is also used in manufacturing dyes, ceramics, detergents, soaps, and medicines.
Mechanism of Action
Similar to calcium chloride, upon administration, calcium lactate is hydrolyzed in the small intestines to its component lactate and calcium ions. The absorption of the calcium ions occurs primarily in the small intestine and is facilitated by vitamin D. After absorption, the calcium ions are redistributed throughout the body and to some degree stored in the bone.
How Long Does It Take to Work?
Calcium is normally absorbed within 45 minutes to 6 hours of taking a calcium lactate supplement. In individuals with a normal healthy gastrointestinal tract, the body’s capacity to absorb calcium is enhanced in the presence of vitamin D.
Absorption
Calcium from calcium lactate is efficiently and readily absorbed in the small intestine when vitamin D is present. In the small intestine, calcium is bound to fatty acids and other organic acids, and its absorption is passive. In the absence of vitamin D, calcium absorption is decreased by up to 50%.
Route of Elimination
Most of the calcium from calcium lactate is excreted in the urine. Some is also excreted in the feces as part of calcium containing food residuums or via the sweat glands.
Dosage
Calcium lactate is usually taken orally as a dietary supplement, often tablet form. The dosage for adults is typically anywhere from 750 mg to 2 g daily, taken in two divided doses. Calcium lactate can also be taken with vitamin D to help improve the absorption of calcium. Consult your physician or healthcare provider for the best dosage for your needs.
Administration
Calcium lactate is very soluble and can be dispensed as a dry powder or tablet and mixed into liquid solutions or as a suspension in liquid or semisolid preparations, such as milk shakes and ice cream, for ease of administration.
Side Effects
Calcium lactate, when taken at the appropriate dose, is generally considered safe, but may cause abdominal upset, nausea, and/or constipation. Taking more than the recommended dose may lead to an overdose of calcium, which can be dangerous.
Toxicity
The toxicity of calcium lactate is very low. An acute overdose is rarely reported and it is unlikely that an overdose of calcium lactate will cause serious adverse impacts in an adult. However, in large doses, calcium lactate can produce stomach upset, diarrhea, nausea, vomiting, and constipation.
Precautions
People with allergies to lactose or other milk products should avoid calcium lactate supplements. Calcium lactate may also interact with certain medications, like thiazide diuretics, digitalis, chelating agents, and bile acid sequestrants, so patients should advise their healthcare provider if on any other medications. Calcium supplements should not be taken with aluminum-containing antacids.
Interactions
Calcium lactate should not be taken with aluminum-containing antacids as it can increase the absorption of aluminum from the antacids. Calcium lactate may also interact with the following medications: thiazide diuretics, digitalis, chelating agents, and bile acid sequestrants.
Disease Interactions
Patients with any of the following diseases should use calcium lactate with caution and under the guidance and supervision of a healthcare provider: kidney stones, kidney failure, high blood calcium levels, sarcoidosis, hypercalcemia, and any disorder causing malabsorption of nutrients.
Drug Interactions
Calcium lactate may interact with certain medications, like thiazide diuretics, digitalis, chelating agents, and bile acid sequestrants, so patients should advise their healthcare provider if on any other medications. Calcium supplements should not be taken with aluminum-containing antacids.
Food Interactions
Calcium supplements should be taken separately from foods that contain high amounts of oxalic acid, such as spinach, rhubarb, and chocolate as the absorption of calcium can be blocked. Calcium lactate should not be taken with products that contain magnesium, phosphorus, or aluminum.
Pregnancy Use
Pregnant women should get the recommended dose of calcium from their prenatal vitamins. However, if not present in prenatal vitamins, calcium lactate can be safely taken during pregnancy in the recommended dosages.
Lactation Use
The recommended amount of calcium is 1200 to 1500 mg/day for women who are breastfeeding. Calcium should be taken in divided doses throughout the day with food. If not present in prenatal vitamins, calcium lactate can be safely taken in the recommended dosages while breastfeeding.
Acute Overdose
Acute overdose with calcium supplements is usually benign, but may cause stomach upset, nausea, vomiting, and constipation. Severe overdose may cause hypercalcemia and renal failure. Treatment of overdose consists of supportive care, fluids, and electrolytes.
Contraindications
Patients with hypercalcemia, renal failure, or kidney stones should avoid taking calcium lactate. Calcium lactate should also be avoided if the patient is taking aluminum antacids or any other medication that contains calcium.
Use Directions
Calcium lactate should be taken as directed by a physician or healthcare provider. It is recommended that patients should take the supplement with food to ensure optimal absorption. Calcium lactate should not be chewed, as this may reduce its effectiveness.
Storage Conditions
Calcium lactate should be stored at room temperature in a tightly sealed container, away from direct sunlight and moisture. Keep out of the reach of children.
Volume of Distribution
The volume of distribution (Vd) of calcium lactate is calculated to be 0.8 L/kg.
Half Life
The half life of calcium lactate is 0.75 hours.
Clearance
The renal clearance (Cl) of calcium lactate is 0.34 mL/min/kg.
Here you find in details version of Callate
Some Frequently Asked Questions About Callate
What is Callate?
Callate is a calcium salt of lactic acid. It can be found in both powder and crystalline form.
Where is Callate found?
Callate can be found in fruits, vegetables, dairy products, yeast, and grains.
What are the benefits of Callate?
Callate can help prevent bone loss, reduce the risk of osteoporosis, improve digestion, and boost the immune system.
What is Callate used for?
Callate is most commonly used as an ingredient in food, beverages, and other edible products. It is also used to treat calcium deficiencies, and as a calcium supplement.
How is Callate made?
Callate is usually produced by combining lactic acid (found in dairy products) and calcium carbonate (found in shells and rocks).
Is Callate safe to take?
Yes, Callate is generally considered safe to take and has few known side effects. However, it is important to consult your doctor before taking it.
Can Callate be used as a supplement?
Yes, Callate can be used as a dietary supplement. It is important to discuss with your doctor before taking any supplement.
How much Callate should be taken?
The recommended daily allowance is 1,000-1,300 mg per day for adults. It is important to discuss with your doctor before taking any supplement.
When should Callate be taken?
It is recommended to take Callate with meals. Taking it on an empty stomach may lead to stomach or digestive upset.
Are there any side effects of taking Callate?
In general, Callate is well tolerated. However, some people may experience minor side effects such as nausea, vomiting, constipation, and abdominal pain.
Does Callate interact with any medications?
Yes, Callate can interact with certain medications such as antibiotics, diuretics, antacids, and bisphosphonates. Therefore, it is important to discuss with your doctor before taking any supplement.
What foods are high in Callate?
Dairy products such as cheese, yogurt, and milk are high in Callate. Other sources include kale, broccoli, and sardines.
What is the shelf life of Callate?
Callate has a shelf life of two years when stored in an airtight container at room temperature.
How should Callate be stored?
Callate should be stored in an airtight container at room temperature and away from direct sunlight.
Is Callate vegan friendly?
Yes, Callate is vegan friendly.
What is the difference between Callate and Calcium Citrate?
Callate is more efficiently absorbed by the body than Calcium Citrate and is often recommended to those who have difficulty absorbing calcium such as those with digestive issues.
Is Callate soluble in water?
Yes, Callate is soluble in water.
Can Callate be taken during pregnancy?
Yes, Callate is generally considered safe for use during pregnancy. However, it is important to consult your doctor before taking any supplement.
Is Callate a natural product?
Yes, Callate is a natural product that is derived from lactic acid.
Is Callate organic?
Yes, Callate is produced from natural sources and is considered an organic product.
What is the best way to take Callate?
Callate is best taken with meals for optimal absorption. It is also important to drink plenty of water throughout the day to help the body absorb the calcium.
Can Callate be added to food?
Yes, Callate can be added to foods such as soups, sauces, smoothies, and baked goods.
Does Callate contain lactose?
No, Callate does not contain significant amounts of lactose.
Is Callate suitable for those on a low carb diet?
Yes, Callate is suitable for those on a low carb diet as it does not contain significant amounts of carbohydrates.
How much Calcium does Callate contain?
Callate contains 12% calcium by weight. Therefore, a one tablespoon serving provides approximately 122.5 mg of calcium.
Are there any health benefits associated with Callate?
Yes, Callate can help reduce the risk of osteoporosis, improve digestion, boost the immune system, and even reduce muscle cramps.
Can Callate be used for baking purposes?
Yes, Callate can be used for baking purposes such as softening dough and improving the rising of baked goods.
When is the best time to take Callate?
It is recommended to take Callate with meals for optimal absorption. It is also important to drink plenty of water throughout the day to help the body absorb the calcium.
What is the recommended dosage of Callate?
The recommended daily allowance is 1,000-1,300 mg per day for adults. It is important to discuss with your doctor before taking any supplement.
Does Callate contain any calories?
No, Callate does not contain any calories.
Is Callate gluten-free?
Yes, Callate is gluten-free.
Does Callate contain any sugar?
No, Callate does not contain any sugar.
Can Callate be used to replace baking powder or baking soda?
Yes, Callate can be used to replace baking powder or baking soda for improved rising and texture of baked goods.
What is the difference between Callate and Calcium Gluconate?
Callate is more efficiently absorbed by the body than Calcium Gluconate and is often recommended to those who have difficulty absorbing calcium such as those with digestive issues.
Does Callate contain any fat?
No, Callate does not contain any fat.
Can Callate be taken with other calcium supplements?
Yes, Callate can be taken with other calcium supplements. However, it is important to discuss with your doctor before taking any supplement.
Can Callate cause stomach distress?
It is possible for Callate to cause stomach distress if taken on an empty stomach. It is therefore recommended to take it with meals.
Does Callate contain any added preservatives?
No, Callate does not contain any added preservatives.
Can Callate help with muscle cramps?
Yes, Callate can help reduce muscle cramps. It is important to discuss with your doctor before taking any supplement.
Can Callate be taken with other medications?
Yes, Callate can be taken with other medications. However, it is important to discuss with your doctor first as there may be potential interactions.
Are there any alternatives to Callate?
Some alternatives to Callate include Calcium Citrate, Calcium Gluconate, and Calcium Carbonate.