Azapin Tablet

Brand Name: Azapin
Generic: Mirtazapine
Weight: 15 mg
Type: Tablet
Therapeutic Class: Atypical anti-depressant drugs
Price: 14.00
Last Updated: 2020-11-20 18:15:00

Azapin Tablet Uses

Azapin Tablet contains Mirtazapine. Azapin uses:

Azapin Tablet Tablets are indicated for the treatment of major depressive disorder.    

The efficacy of Azapin Tablet in the treatment of major depressive disorder was established in 6-week controlled trials of outpatients whose diagnoses corresponded most closely to the Diagnostic and Statistical Manual of Mental Disorders- 3rd edition (DSM-III) category of major depressive disorder     

A major depressive episode (DSM-IV) implies a prominent and relatively persistent (nearly every day for at least 2 weeks) depressed or dysphoric mood that usually interferes with daily functioning, and includes at least 5 of the following 9 symptoms: depressed mood, loss of interest in usual activities, significant change in weight and/or appetite, insomnia or hypersomnia, psychomotor agitation or retardation, increased fatigue, feelings of guilt or worthlessness, slowed thinking or impaired concentration, a suicide attempt, or suicidal ideation.    

The effectiveness of Azapin Tablet in hospitalized depressed patients has not been adequately studied.    

The efficacy of Azapin Tablet in maintaining a response in patients with major depressive disorder for up to 40 weeks following 8 to 12 weeks of initial open-label treatment was demonstrated in a placebo-controlled trial. Nevertheless, the physician who elects to use Azapin Tablet for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient

Azapin Tablet Doses

Azapin Tablet contains Mirtazapine 15 mg. Azapin doses:

Adult: Initially, 15 mg daily; may be increased gradually depending on clinical response. Change dose at intervals of at least 1-2 wk. Usual effective dose: 15-45 mg daily given as single dose, preferably at bedtime, or in 2 divided doses.

Children: Safety and efficacy not established.

Geriatric: Use with caution.


Side Effects

The most commonly reported adverse effects with mirtazapine are increase in appetite, weight gain, edema, drowsiness or sedation, dizziness, headache etc.


Azapin Tablet, a piperazinoazepine tetracyclic antidepressant, enhances noradrenergic and serotonergic activity through blockade of central presynaptic adrenergic α2-receptors.

Azapin Precaution

Azapin Tablet should be used cautiously in patients with epilepsy or history of seizure, history of mania /hypomania, patients with hepatic or renal impairment; cardiac disorders e.g. conduction disturbances, angina pectoris, recent MI. Hypotension, DM, psychoses, history of bipolar disorder. Stop treatment if jaundice develops. Monitor patient for signs of bone marrow depression. Monitor patient for suicidal tendency. Avoid abrupt withdrawal. May impair ability to drive or operate machinery.


Azapin Tablet potentiates sedative effects with alcohol or benzodiazepines, increased plasma levels with potent CYP3A4 inhibitors (e.g. HIV-protease inhibitors, azole antifungals including ketoconazole, erythromycin, nefazodone), reduced plasma levels with carbamazepine and other inducers of CYP3A4 and increased bioavailability with cimetidine.

Pregnancy Lactation use

Azapin Tablet Should not be used during pregnancy and lactation.


Azapin Tablet is contraindicated in patients with hypersensitivity. Do not use with or within 2 weeks of stopping an MAOI; at least 1 week should elapse between discontinuing mirtazapine and initiating any drug which may provoke a serious reaction (e.g. phenelzine)

Special Warning


Acute Overdose

Symptoms: Disorientation, drowsiness, impaired memory, tachycardia. 

Management: Ensure an adequate airway, oxygenation, and ventilation. Monitor cardiac functions. General supportive and symptomatic measures are also recommended. Do not induce emesis. Gastric lavage may be used if done soon after ingestion, or in symptomatic patients. Administer activated charcoal. No specific antidotes are known.

Interaction with other Medicine


Storage Condition

Store at 15-30° C . Protect from light and moisture.

Azapin Tablet price in Bangladesh 14.00