Avalon IV Infusion

Brand Name: Avalon
Generic: Azithromycin
Weight: 500 mg/vial
Type: IV Infusion
Therapeutic Class: Macrolides
Manufacturer: Techno Drugs Ltd.
Price: 350.00
Last Updated: 2020-11-21 18:15:00
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Avalon IV Infusion Uses

Avalon IV Infusion contains Azithromycin. Avalon uses:

Avalon IV Infusion is indicated for infections caused by susceptible organisms in-

Upper respiratory tract infections including sinusitis, pharyngitis and tonsillitis

Lower respiratory tract infections including bronchitis, acute bacterial exacerbations of chronic obstructive pulmonary

disease (COPD)

Otitis media

Skin and soft tissue infections including cellulitis, pyoderma, erysipelas, wound infections

Diarrhea, Shigellosis

Sexually transmitted diseases, especially in the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis

Genital ulcer disease in men due to Haemophilus ducreyi (chancroid)

Mild or moderate typhoid due to multiple-antibacterial resistant organisms

Prophylaxis against a-hemolytic (viridans group) streptococcal bacterial endocarditis

Other infections including odontogenic infections, bartonella infections, toxoplasmosis, babesiosis

Avalon IV Infusion Doses

Avalon IV Infusion contains Azithromycin 500 mg/vial. Avalon doses:

Avalon IV Infusion tablet can be taken with or without food. Avalon IV Infusion suspension should be taken at least 1 hour before or 2 hours after meal.

 

Oral:

Adult:

For respiratory tract infections, otitis media and skin & soft tissue infections: 500 mg once daily for 3 days or an alternative to this as 500 mg once on day 1, followed by 250 mg once daily for next 4 days. For sexually transmitted diseases like genital ulcer, non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis : a single 1 gm (1000 mg) dose. For the treatment of urethritis and cervicitis due to Neisseria gonorrhoeae : a single 2 gm (2000 mg) dose. In typhoid, 500 mg once daily for 7 days. In Cholera, a single 1 gm (1000 mg) dose. In Shigellosis, 500 mg once on day 1, followed by 250 mg once daily for next 4 days.

Avalon IV Infusion can be taken with or without food.

To reconstitute Avalon IV Infusion 15 ml powder for suspension: Add 10 ml or 2 tea spoonfuls of just boiled and cooled water to the content of the bottle and shake well to mix uniformly. 

To reconstitute Avalon IV Infusion 30 ml powder for suspension: Add 20 ml or 4 tea spoonfuls of just boiled and cooled water to the content of the bottle and shake well to mix uniformly. 

To reconstitute Avalon IV Infusion 50 ml powder for suspension: Add 35 ml or 7 tea spoonfuls of just boiled and cooled water to the content of the bottle and shake well to mix uniformly.

Side Effects

Avalon IV Infusion is well tolerated with a low incidence of side efects. The side effects include nausea, vomiting, abdominal discomfort (pain/cramps), flatulence, diarrhea, headache, dizziness, and skin rashes and are reversible upon discontinuation of therapy. Reversible elevations in liver transaminases have been observed occasionally. Transient mild reductions in neutrophil counts have occasionally been observed in clinical trials, although causal relationship to Avalon IV Infusion has not been established.

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Introduction

Avalon IV Infusion is an azalide antibiotic, a subclass of macrolide antibiotic. It acts by binding to the 50s ribosomal subunit of susceptible microorganisms and thus interfering with microbial protein synthesis. Avalon IV Infusion has been shown to be active against most strains in the following microorganisms, both In vitro and in clinical infections:

Gram-positive microorganisms: Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes.

Gram-negative microorganisms: Haemophilus ducreyi, Haemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae, Escherichia coli.

Other microorganisms: Chlamydia pneumoniae, Chlamydia trachomatis, Mycoplasma pneumoniae, Bacteroides fragilis, Legionella pneumophila, oxoplasma gondii.

Avalon Precaution

As with any antibiotic, observation for signs of super infection with non-susceptable organisms, including fungi, is recommended. Precaution should be taken in patients with more severe renal impairment.

Interaction

Antacids: Peak serum levels but not the total extent of absorption are reduced by aluminium and magnesium containing antacids in the stomach. Avalon IV Infusion should therefore be taken at least 1 hour before or 2 hours after taking these antacids. 

Ergot Derivatives: Because of the theoretical possibility of ergotism, concomitant administration of ergot derivatives and Avalon IV Infusion should be avoided. Digoxin & Cyclosporin: Macrolides have been known to increase the plasma concentration of Digoxin & Cyclosporin and so caution should be exercised while co-administration is necessary. 

Anti-Histamines: A potentially life threatening interaction between erythromycin and terfenadine or astemizole have been reported. Although such an interaction with Avalon IV Infusion is not established yet, it is wise to avoid concomitant use of Avalon IV Infusion and terfenadine or astemizole.

Pregnancy Lactation use

Pregnancy: US FDA pregnancy category B. In the animal studies, no evidence of harm to the fetus due to Avalon IV Infusion was found. Because animal reproduction studies are not always predictive of human response, Avalon IV Infusion should be used during pregnancy only if clearly needed.

Lactation: It is not known whether Avalon IV Infusion is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Avalon IV Infusion is administered to nursing mother.

Contraindication

Avalon IV Infusion is contraindicated in patients hypersensitive to Avalon IV Infusion or any other macrolide antibiotic. Co-administration of ergot derivatives and Avalon IV Infusion is contraindicated. Avalon IV Infusion is contraindicated in patients with hepatic diseases.

Special Warning

Pediatric Use: Avalon IV Infusion oral dosage forms can be administered to pediatric patients from 6 months of age. Safety and effectiveness of azithromycin for injection in children or adolescents under 16 years have not been established.

Acute Overdose

There are no data available on overdose with Avalon IV Infusion. Typical symptoms of overdosage with macrolide antibiotics include hearing loss, severe nausea, vomiting and diarrhoea. Gastric lavage and general supportive measures are indicated.

Interaction with other Medicine

Peak serum levels but not the total extent of absorption were reduced by the presence of magnesium and aluminum-containing antacids. Avalon IV Infusion should be taken at least 1 hr before or 2 hrs after these antacids. In patients receiving ergot alkaloids, Avalon IV Infusion should be avoided concurrently because of the possibilty of ergotism result in from interaction of Avalon IV Infusion with the cytochrome P-450 system However, no cases of such interaction have been reported. Macrolides have been known to increase the plasma concentration of digoxin and cyclosporine. Therefore, if co-administration is necessary caution should be exercised and serum levels of digoxin and cyclosporine should be checked. There have been no pharmacokinetic drug interactions between Avalon IV Infusion and warfarin, theophylline, carbamazepine, methylprednisolone and cimetidine.

Storage Condition

Avalon IV Infusion IV infusion: When diluted according to the instructions, azithromycin for injection is stable for 24 hours at or below room temperature 30° C, or for 7 days if stored under refrigeration 5° C.

Avalon IV Infusion capsule, tablet and dry powder for suspension: should be stored at room temperature (below 30° C). Any unused portion of reconstituted Avalon IV Infusion suspension should be discarded after 5 days.

Avalon IV Infusion eye drops: Store unopened bottle under refrigeration at 2°C to 8°C. Once the bottle is opened, store at 2°C to 25°C for up to 14 days. Discard after the 14 days.

Avalon IV Infusion price in Bangladesh 350.00

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