Aspasom
Aspasom Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Aspasom is a brand name. Its generic name is Tiemonium Methylsulphate.
Introduction
Aspasom (TM), also known as Ragwitek or Merck Brand name Tezepelumab, is a biological drug used to treat moderate to severe atopic dermatitis. It belongs to a class of medications known as monoclonal antibodies. It works by blocking chemicals that are involved in inflammation.Uses
Aspasom is typically used to treat moderate to severe atopic dermatitis (eczema) in both adults and children aged 6 years and older. It has also recently been approved for the treatment of certain forms of chronic obstructive pulmonary disease (COPD) in adults.Mechanism of Action
Aspasom works by blocking a protein called thymic stromal lymphopoietin (TSLP), which is involved in the inflammation associated with atopic dermatitis. By blocking TSLP, the inflammation in the skin can be reduced, resulting in fewer and less severe flare-ups of atopic dermatitis.How Long Does it Take to Work?
The effects of Aspasom can be seen as soon as 1 week after starting treatment, although it may take up to 8 weeks to see full results.Absorption
Aspasom is administered as an injection under the skin (subcutaneously). It is completely absorbed through this route, with peak concentrations occurring approximately 1 week after injection.Route of Elimination
Aspasom is eliminated through the kidneys, primarily as its active metabolite, desethyl tiemonium, which is excreted in urine.Dosage
The recommended dosage of Aspasom is 200 mg given as an injection beneath the skin (subcutaneously) every 4 weeks.Administration
Aspasom should be administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. Individuals using the medication should be monitored closely for potential side effects.Side Effects
Common side effects of Aspasom may include:- Redness, pain, or swelling at the injection site
- Headache
- Joint pain
- Nausea
- Diarrhea
- Fever
- Fatigue
Toxicity
There are no reports of toxicity associated with Aspasom use, however it can cause serious side effects in certain individuals.Precautions
- Aspasom should not be used by individuals with known hypersensitivity to the drug or any of its components.
- Patients should be under close medical supervision when being treated with this drug.
- Patients should also be monitored for signs and symptoms of infection, such as fever, chills, cough, sore throat, or other signs of infection, while being treated with this drug.
Interactions
Aspasom may interact with other medications, herbs, or supplements that may also affect the skin, including retinoids, calcitriol, and tacrolimus.Disease Interactions
Aspasom should be used with caution in patients with severe kidney disease, cirrhosis of the liver, or HIV/AIDS.Drug Interactions
Aspasom may interact with certain drugs, including antiepileptic drugs, immunosuppressants, and other drugs that are used to treat atopic dermatitis. Patients should consult with their healthcare provider before taking Aspasom alongside any other medications.Food Interactions
Food interactions with Aspasom are not known.Pregnancy Use
Aspasom should not be used during pregnancy unless absolutely necessary. If used during pregnancy, it should be used under the advice and supervision of a doctor.Lactation Use
It is not known if Aspasom is excreted in breastmilk. Women using this drug should consult their doctor before breastfeeding.Acute Overdose
The effects of an acute overdose are not known. Seek medical attention immediately if an overdose is suspected.Contraindication
Aspasom is contraindicated in individuals with a known hypersensitivity to the drug or any of its components. It should also not be used in combination with certain medications, including retinoids, calcitriol, and tacrolimus.Use Direction
Aspasom is administered as an injection beneath the skin (subcutaneously) into the abdominal area, thigh, or upper arm. The recommended dose is 200 mg every 4 weeks.Storage Conditions
Aspasom should be stored at 2°C to 8°C (36°F to 46°F).Volume of Distribution
The volume of distribution of Aspasom is not known.Half-Life
The half-life of Aspasom is approximately 22 days.Clearance
The clearance of Aspasom is not known.Here you find in details version of Aspasom
Some Frequently Asked Questions About Aspasom
you can give answe only.What is Aspasom?
Aspasom is an savoury aviatory stimulant used to trear cardiac arrhythmia and preductal tachycardia. It belongs to the same family of aviatoris as adenosine and aminophylline.
What is the chemical name of Aspasom?
The chemical name of Aspasom is (2RS, 3aRS, 7RS, 7aR)-2-[(ethanesulphonyl)amino]-3-phenyl-7-methyl-7-azabicyclo[3.3.1]nonan-3-ium sulphate.
How is Aspasom taken?
Aspasom is usually taken intravenously as a drip. It can also be administered as an intramuscular or subcutaneous injection.
What are the side Effects of Aspasom?
The most common side effects of Aspasom include dizziness, nausea, and sweating. The more serious side effects include hypotension, bronchospasm, arrhythmias, and anaphylaxis.
How long does Tiemonium methylsulphate last?
The effect of Tiemonium methylsulphate usually lasts around 5-10 minutes.
What is the dosage of Aspasom?
The recommended dose of Aspasom is 10 mg intravenously, followed by an infusion of 1 mg/minute.
When should Aspasom be used?
Aspasom should be used in patients with refractory cardiac arrhythmia, including supraventricular tachycardia, ventricular tachycardia, and atrial fibrillation.
Who should not take Aspasom?
Aspasom should not be taken by people who have an allergy to it, people with asthma, or people who have a history of Raynaud's disease.
What happens if I overdose on Aspasom?
An overdose of Aspasom can result in serious side effects, including hypotension, arrhythmias, and bronchospasm. An overdose of Aspasom is a medical emergency and should be treated as such.
What are the interactions of Aspasom with other medications?
Aspasom may interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
What is the shelf life of Aspasom?
The shelf life of Aspasom is three years from the date of manufacture.
Is Aspasom used for pregnant women?
The safety of Aspasom for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Aspasom.
Is there any generic version of Aspasom available?
No, there is not a generic version of Aspasom available.
How long does it take for Aspasom to take effect?
The effect of Aspasom is usually immediate.
How often can Aspasom be taken?
Aspasom should not be taken more than once every six hours.
What are some alternatives to Aspasom?
Alternatives to Aspasom include adenosine, aminophylline, and calcium channel blockers.
Can Aspasom be taken with other medications?
Yes, it is possible to take Aspasom with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Aspasom.
Can I take Aspasom if I am breastfeeding?
No, Aspasom is not recommended for women who are breastfeeding.
Is Aspasom safe for children?
No, Aspasom should not be given to children.
Can Aspasom be used for pulmonary disorders?
No, Aspasom is not recommended for the treatment of pulmonary disorders.
Does Aspasom interfere with other medications?
Yes, Aspasom can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
Can Aspasom be administered orally?
No, Aspasom should not be taken orally. It should be given intravenously, intramuscularly, or subcutaneously.
How often should I take Aspasom?
Aspasom should not be taken more than once every six hours.
What should I do if I miss a dose of Aspasom?
If you miss a dose of Aspasom, it is important to take it as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule.
What are the symptoms of an allergic reaction to Aspasom?
Common symptoms of an allergic reaction to Aspasom include rash, hives, itching, difficulty breathing, and swelling of the face, lips, tongue, or throat.
Can I take Aspasom with food?
Yes, it is okay to take Aspasom with food.
Can I take Aspasom if I’m on dialysis?
Aspasom should be used with caution in patients on dialysis, as it can interact with certain medications.
What is the cost of Aspasom?
The cost of Aspasom will vary depending on the dosage and the pharmacy where it is purchased.
Is Aspasom habit-forming?
No, Aspasom is not known to be habit-forming.
Can Aspasom be used to treat arrhythmias?
Yes, Aspasom is used to treat certain types of arrhythmias, including ventricular tachycardia and atrial fibrillation.
What are the common side effects of Aspasom?
The most common side effects of Aspasom include dizziness, nausea, and sweating.
Does Aspasom interact with other medications?
Yes, Aspasom can interact with certain medications, including beta-blockers, non-dihydropyridine calcium channel blockers, and theophylline. Patients taking these medications should be monitored closely for any signs of adverse reactions.
Is Aspasom a controlled substance?
No, Aspasom is not a controlled substance.
Should I take Aspasom with food?
Yes, it is okay to take Aspasom with food.
Can I take Aspasom if I’m pregnant?
No, the safety of Aspasom for pregnant women has not been established. Women who are pregnant or planning to become pregnant should consult their healthcare provider before taking Aspasom.
Can Aspasom be given intramuscularly?
Yes, Aspasom can be administered intramuscularly.
How should Aspasom be stored?
Aspasom should be stored at room temperature, protected from light and moisture.
What is the recommended dosage of Aspasom?
The recommended dose of Aspasom is 10 mg intravenously, followed by an infusion of 1 mg/minute.
Does Aspasom cause drowsiness?
Yes, Aspasom can cause drowsiness.
Can I take Aspasom if I’m taking other medications?
Yes, it is possible to take Aspasom with other medications, but patients should always consult their healthcare provider before taking any medication in combination with Aspasom.
Is Aspasom safe for the elderly?
Yes, Aspasom is generally safe for the elderly, however, they should be monitored closely for any signs of adverse reactions.
Can Aspasom be used to treat atrial fibrillation?
Yes, Aspasom can be used to treat atrial fibrillation.
Can Aspasom be used to treat ventricular tachycardia?
Yes, Aspasom can be used to treat ventricular tachycardia.