Arex-160
Arex-160 Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Arex-160 is a brand name. Its generic name is Artemether.
Arex-160 Introduction
Arex-160 is an antimalarial drug used to treat and prevent malaria. It is a semi-synthetic derivative of artemisinin, an active compound isolated from a Chinese herb, Artemisia annua. Arex-160 is most commonly used in combination with other antimalarials to effectively treat multi-drug resistant malaria.Uses of Arex-160
Arex-160 is used to treat and prevent malaria caused by the Plasmodium falciparum parasite. It is usually used in combination with other antimalarials, such as lumefantrine, mefloquine, and quinine. It is also used to treat severe or complicated malaria, uncomplicated Plasmodium vivax malaria, and mild or asymptomatic falciparum malaria.Mechanism of Action
Arex-160 works by interfering with parasite replication and metabolism within red blood cells, eventually leading to the blockage of essential metabolic pathways and death of the parasite. It also triggers a rapid release of hemoglobin, which causes a reduction in parasite growth and a decrease in parasitemia.How Long Does It Take to Work?
The effects of artemether usually become evident within 24-48 hours of administration. Treatment usually lasts for 3 to 7 days, depending on the severity of the infection. However, it is important to take all doses as prescribed to ensure complete treatment of malaria.Absorption, Route, and Dosage of Arex-160
Arex-160 is quickly and almost completely absorbed after oral administration. It is metabolized in the liver and the peak plasma levels are achieved between 4 and 6 hours after administration. The usual dose of artemether is 80 mg to 160 mg orally per day for adults.Administration
Arex-160 is commercially available as an oral tablet or liquid. It should be taken with food for optimal absorption.Side Effects
The most commonly reported side effects of artemether are diarrhea, nausea, abdominal pain, headache, and rash.Toxicity
In clinical trials, the most commonly reported adverse reactions to artemether were mild to moderate and reversible. In rare cases, serious and potentially life-threatening reactions may occur such as cardiac arrhythmias, hepatitis, and thrombocytopenia.Precaution
Arex-160 should not be used in individuals who are hypersensitive to other medications. Patients with liver or kidney disease, glucose-6-phosphate dehydrogenase deficiency, or any other serious medical condition should use artemether with caution.Interactions
Arex-160 may interact with other medications such as antacids, anticoagulants, ca carbons, and oral contraceptives.Disease Interactions
Patients with diabetes, liver or kidney disease, and other serious medical conditions should use artemether with caution.Drug Interactions
Arex-160 may interact with drugs such as antacids, oral contraceptives, anticoagulants, and cation-containing salts.Food Interactions
Arex-160 can interact with certain foods such as grapefruit, cranberry, pomegranate, and alcohol.Pregnancy Use
Arex-160 is not recommended for use during pregnancy.Lactation Use
Arex-160 is not recommended during lactation as it can pass into breast milk.Acute Overdose
In case of an overdose, seek immediate medical help. Symptoms of an overdose may include lower blood pressure, rash, breathing difficulties, and stomach upset.Contraindication
Arex-160 should not be used in patients who have a known hypersensitivity to the drug or its ingredients.Use Direction
Arex-160 should be taken as directed by the healthcare professional. The usual dose of artemether is 80 mg to 160 mg orally per day. Please refer to the prescription label for the exact dosing instructions.Storage Condition
Arex-160 should be stored at room temperature and away from heat, light, and moisture.Volume of Distribution
The volume of distribution of artemether is 5.5 – 6 L/kg.Half Life
The half-life of artemether is approximately 3–4 hours.Clearance
The clearance of artemether is 3 – 4 L/kg/h.Here you find in details version of Arex-160
Some Frequently Asked Questions About Arex-160
What is artemether?
Arex-160 is an antimalarial drug used to treat and prevent certain types of malaria. It is a type of medication known as an artemisinin, which works to kill the malaria parasites by blocking their ability to multiply and spread.
Is artemether an antibiotic?
No, artemether is not an antibiotic. It is an antimalarial medication.
What is artemether used for?
Arex-160 is used to treat and prevent certain types of malaria. It is most commonly used in combination with other medications to treat acute, severe malaria. Arex-160 can also be used as an alternative to other antimalarial drugs in cases where the malaria is resistant to other medications.
What are the side effects of artemether?
The most common side effects of artemether include nausea, vomiting, headache, dizziness, abdominal pain, and diarrhea. Uncommon side effects include rash, itching, hives, and difficulty breathing. If you experience any of these side effects, contact your doctor immediately.
How long does artemether take to start working?
Arex-160 typically starts working within hours of taking it. However, it may take up to several days before the full effect of the medication is seen.
Are there any drug interactions with artemether?
Yes, certain drugs can interact with artemether. Always tell your doctor and pharmacist about any other medications you are taking, including vitamins, herbal supplements, and over-the-counter medications.
What is the recommended dosage for artemether?
The recommended dosage for artemether varies depending on age, weight, and other factors. It is important to follow the directions of your doctor when taking artemether.
Can artemether be taken by children?
Yes, artemether is safe for children when taken as directed. However, it is important to check with your doctor before giving this medication to any child.
Is artemether available in generic form?
No, artemether is not available in generic form. It must be prescribed by a doctor.
Can I get artemether without a prescription?
No, artemether requires a prescription from a doctor and cannot be obtained without one.
Can I buy artemether over the counter?
No, artemether cannot be purchased over the counter and requires a prescription from a doctor.
Is it safe to take artemether during pregnancy?
Yes, artemether is generally considered safe to take during pregnancy. However, it is always best to talk to your doctor first before taking any medication during pregnancy.
How long does artemether stay in your system?
The amount of time that artemether remains in your system varies and is dependent upon the individual. The drug has an elimination half-life of about 11-17 hours.
Can artemether be taken with other medications?
Yes, artemether can be taken with certain other medications. However, certain medications may interact with artemether, so it is important to check with your doctor or pharmacist before taking any other medications.
Can artemether cause skin rash?
Yes, artemether may cause a skin rash in some people. If you experience a skin rash while taking artemether, contact your doctor immediately.
What are the symptoms of an artemether overdose?
Symptoms of an artemether overdose may include nausea, vomiting, abdominal pain, headache, dizziness, confusion, weakness, and irregular heart rate. If you think you or someone else has taken too much artemether, contact poison control or emergency medical help right away.
Is artemether available in liquid form?
Yes, artemether is available in liquid form. This form of the medication is typically used for children and infants.
What should I do if I miss a dose of artemether?
If you miss a dose of artemether, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue on your regular schedule.
Can I take artemether with food?
Yes, taking artemether with food can help reduce side effects such as nausea and vomiting. However, it is important to check with your doctor or pharmacist for the best way to take artemether.
Can artemether cause liver damage?
Yes, artemether can cause liver damage in rare cases. If you experience signs of liver damage while taking artemether, contact your doctor immediately.
Is artemether available in injection form?
Yes, artemether is available in injection form. This form of the medication is typically used for severe or life-threatening cases of malaria.
Can I take artemether while breastfeeding?
Yes, artemether is generally considered safe to take while breastfeeding. However, it is always best to talk to your doctor first before taking any medication while breastfeeding.
What is the typical treatment duration for artemether?
The typical treatment duration for artemether is 5 to 7 days. However, this may vary depending on the individual and the severity of the malaria.
Will artemether prevent malaria in the future?
No, artemether is not a preventative medication, and should not be used as such. It is important to take preventative measures such as wearing protective clothing and using mosquito repellent when traveling to areas with high levels of malaria.
Can artemether be used to treat chloroquine-resistant malaria?
Yes, artemether can be used to treat chloroquine-resistant malaria. It is typically combined with other medications in order to ensure the malaria parasite is completely eradicated.
What should I do if I develop allergic reaction to artemether?
If you develop a rash, hives, difficulty breathing, or any other type of allergic reaction while taking artemether, stop taking the medication and contact your doctor immediately.
Are there other medications similar to artemether?
Yes, there are other medications similar to artemether, such as quinine, mefloquine, halofantrine, atovaquone/proguanil, and doxycycline. However, not all are effective against all types of malaria, and some may have different side effects than artemether.
How long can artemether be stored?
Arex-160 can be stored for up to 1 year if kept in its original packaging and stored at room temperature. It should not be stored in the refrigerator or frozen.
What should I do if I experience severe diarrhea while taking artemether?
If you experience severe diarrhea while taking artemether, contact your doctor immediately as this could be a sign of an adverse reaction. It is important to drink plenty of fluids and avoid taking antidiarrheal medications unless as directed by your doctor.
Can artemether be taken with antacids?
Yes, artemether can be taken with antacids. It is important to take the antacid at least one hour before or after taking artemether to ensure proper absorption of the medication.
What form of artemether is best absorbed by the body?
The oral form of artemether is best absorbed by the body. Injections of artemether may result in lower levels of the medication in the bloodstream.
Can artemether cause dizziness?
Yes, artemether may cause dizziness or lightheadedness in some individuals. If you experience these side effects, contact your doctor immediately.
What is the difference between artemether and artesunate?
Arex-160 and artesunate are both derivatives of the antimalarial medication artemether. Arex-160 is typically used to treat acute, severe malaria, while artesunate is most commonly used to prevent malaria. They both belong to the artemisinin family of antimalarial medications.
Is there an antidote for an artemether overdose?
No, there is no specific antidote for an artemether overdose. Symptoms of an overdose may be managed with supportive care such as fluids and medications to reduce nausea and vomiting.
Can artemether be used to treat malaria in India?
Yes, artemether is approved for use in India to treat malaria caused by Plasmodium parasites. It is recommended to take this medication in combination with other antimalarial drugs for the best results.
What are the warnings associated with artemether?
Arex-160 should not be used in patients with severe renal impairment without close monitoring. Arex-160 can cause dizziness or impaired vision and it is important to use caution when driving or operating machinery while taking this medication.
Can artemether interact with herbal supplements?
Yes, certain herbal supplements may interact with artemether. It is important to tell your doctor and pharmacist about any herbal supplements you are taking to ensure no dangerous drug interactions occur.
Can artemether be taken with corticosteroids?
Yes, artemether can be taken with corticosteroids. However, it is important to check with your doctor and pharmacist before taking any other medications to ensure there are no dangerous interactions.
What is the recommended dose of artemether for adults?
The recommended dose of artemether for adults is 4-8 mg/kg body weight per day, split into two doses. However, the exact dose should be determined by your doctor, based on your age, weight, and other factors.