|Therapeutic Class:||Second generation Cephalosporins|
|Last Updated:||2020-11-20 18:15:00|
Aprozil Tablet contains Cefprozil. Aprozil uses:
Aprozil Tablet is indicated for the treatment of patients with mild to moderate infections caused by susceptible strains. Infections include:
Aprozil Tablet contains Cefprozil 500 mg. Aprozil doses:
Adult: 500 mg daily as a single or in 2 divided doses, increased to 500 mg bid if necessary. Duration: 10 days.Child (6 month to 2 year):
Child (>2 yr):
Aprozil Tablet was usually well tolerated in controlled clinical trials. The most common adverse effects of cefprozil are diarrhea, nausea, vomiting, abdominal pain, rash, urticaria, dizziness, hyperactivity, insomnia, confusion etc.
Aprozil Tablet is a semi synthetic, second generation cephalosporin antibiotic. Aprozil Tablet is active in vitro against both gram positive and gram negative bacteria. The bactericidal activity of cefprozil results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Aprozil Tablet inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
History of hypersensitivity to penicillins and GI disease esp colitis. Renal impairment. Pregnancy and lactation.
May enhance the nephrotoxic effect of aminoglycosides. May enhance the anticoagulant effect of vit K antagonists. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. May increase serum concentrations w/ probenecid.
Pregnancy category B. There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. Small amounts of cefprozil (<0.3% of dose) have been detected in human milk following administration of a single 1 gram dose to lactating women. Caution should be exercised when cefprozil is administered to a nursing woman, since the effect of cefprozil on nursing infants is unknown.
Hypersensitivity to cephalosporin antibiotics.
Store between 20-25°C. Reconstituted powder for suspension: Store between 2-8°C.
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