Aprozil Tablet

Brand Name:	Aprozil
Generic:	Cefprozil
Weight:	250 mg
Type:	Tablet
Therapeutic Class:	Second generation Cephalosporins
Manufacturer:	Aristopharma Ltd.
Price:	0.00
Last Updated:	2020-11-20 18:15:00

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Aprozil Tablet Uses

Aprozil Tablet contains Cefprozil. Aprozil uses:

Aprozil Tablet is indicated for the treatment of patients with mild to moderate infections caused by susceptible strains. Infections include:

Lower respiratory tract infections: acute bronchitis, acute exacerbations of chronic bronchitis, community acquired pneumonia.
Upper respiratory tract and ear infections: otitis media, sinusitis, tonsillitis and pharyngitis.
Uncomplicated skin and soft tissue infections.

Aprozil Tablet Doses

Aprozil Tablet contains Cefprozil 250 mg. Aprozil doses:

Adult: 500 mg daily as a single or in 2 divided doses, increased to 500 mg bid if necessary. Duration: 10 days.Child (6 month to 2 year):

For otitis media: 15 mg/kg 12 hrly.
For acute sinusitis: 7.5 mg/kg or 15 mg/kg 12 hrly.
For pharyngitis or tonsillitis: 7.5 mg/kg 12 hourly.

Child (>2 yr):

For skin and skin structure infections: 20 mg/kg daily. Max: 1 g daily.

Side Effects

Aprozil Tablet was usually well tolerated in controlled clinical trials. The most common adverse effects of cefprozil are diarrhea, nausea, vomiting, abdominal pain, rash, urticaria, dizziness, hyperactivity, insomnia, confusion etc.

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Introduction

Aprozil Tablet is a semi synthetic, second generation cephalosporin antibiotic. Aprozil Tablet is active in vitro against both gram positive and gram negative bacteria. The bactericidal activity of cefprozil results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).

Aprozil Tablet inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Aprozil Precaution

History of hypersensitivity to penicillins and GI disease esp colitis. Renal impairment. Pregnancy and lactation.

Interaction

May enhance the nephrotoxic effect of aminoglycosides. May enhance the anticoagulant effect of vit K antagonists. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. May increase serum concentrations w/ probenecid.

Pregnancy Lactation use

Pregnancy category B. There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. Small amounts of cefprozil (<0.3% of dose) have been detected in human milk following administration of a single 1 gram dose to lactating women. Caution should be exercised when cefprozil is administered to a nursing woman, since the effect of cefprozil on nursing infants is unknown.