Apilast
Apilast Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Apilast is a brand name. Its generic name is Apremilast.
Aprmielast Introduction
Aprmielast is a prescription oral medication used to treat psoriatic arthritis and moderate to severe plaque psoriasis. It is an inhibitor of phosphodiesterase 4 (PDE4), an enzyme which plays a role in inflammation and immune response. Aprmielast is available in tablet form and is taken once a day.
Uses For
Aprmielast is indicated for the treatment of moderate to severe plaque psoriasis in adults and for the treatment of adults with active psoriatic arthritis. Aprmielast is not indicated for the treatment of other forms of arthritis.
Mechanism of Action
Aprmielast works by inhibiting the activity of the enzyme phosphodiesterase 4 (PDE4), which is involved inflammation. By blocking PDE4 activity, Aprmielast helps to reduce inflammation and reduce the symptoms associated with plaque psoriasis and psoriatic arthritis.
How Long Does it Take to Work?
The effect of Aprmielast can be seen within 4 to 6 weeks of treatment. Maximum effectiveness may not be seen until 12 weeks or longer. May take up to 16 weeks or longer to achieve maximum benefit.
Absorption
Aprmielast is rapidly absorbed after oral dosing. Peak concentrations are generally reached 2-3 hours after administration.
Route of Elimination
Aprmielast is eliminated from the body via renal excretion. About 65% of the absorbed dose is excreted unchanged in the urine.
Dosage
The recommended dosage of Aprmielast is 30 mg taken twice daily. This dosage can be increased to 60 mg twice daily if needed. Aprmielast should be taken with food in order to reduce the chance of stomach upset or diarrhea.
Administration
Aprmielast tablets should be swallowed whole with a glass of water. They should not be chewed, crushed, or broken. It is important to take Aprmielast exactly as directed by your healthcare provider.
Side Effects
Some common side effects of Aprmielast may include nausea, headache, diarrhea, abdominal pain, and fatigue. More serious side effects may include depression and suicidal thoughts.
Toxicity
Aprmielast has not been found to be toxic in clinical trials. However, patients should be monitored for serious side effects such as depression and suicidal ideation.
Precautions
Aprmielast should be used with caution in patients with a history of depression or other mental health conditions. It is important to discuss any concerns with your doctor before starting Aprmielast.
Interactions
Aprmielast may interact with certain prescription or over-the-counter medications, so it is important to discuss any potential drug interactions with your doctor before using Aprmielast.
Disease Interactions
Aprmielast may interact with certain diseases, such as depression or other mental health conditions. It is important to discuss any existing medical conditions with your doctor before using Aprmielast.
Drug Interactions
Aprmielast may interact with certain drugs. Be sure to tell your doctor about any other medications you may be taking before using Aprmielast.
Food Interactions
Foods that contain high-fat content may decrease the amount of Aprmielast that is absorbed. It is therefore recommended to avoid high-fat foods such as French fries when taking Aprmielast.
Pregnancy Use
Aprmielast has not been studied in pregnant women and therefore is not recommended for use in pregnant women. Women should speak to their doctor before taking Aprmielast if they are pregnant or planning to become pregnant.
Lactation Use
It is not known if Aprmielast is excreted in breast milk. Therefore, Aprmielast should not be used while breastfeeding.
Acute Overdose
If an overdose of Aprmielast is suspected, contact the Poison Control Center at 1-800-222-1222. Symptoms of overdose may include nausea, vomiting, abdominal pain, and diarrhea.
Contraindication
Aprmielast is contraindicated in patients with a known hypersensitivity to the drug, as well as those with severe liver impairment.
Use Directions
Aprmielast should be taken exactly as prescribed by your healthcare provider. It is important to take Aprmielast with food in order to reduce the chance of stomach upset or diarrhea.
Storage Conditions
Aprmielast should be stored at room temperature, away from light and moisture. It should not be kept in the refrigerator.
Volume of Distribution
The volume of distribution for Aprmielast is not known.
Half Life
The half life for Aprmielast is approximately 13 hours.
Clearance
The clearance of Aprmielast is not known.
Here you find in details version of Apilast
Some Frequently Asked Questions About Apilast
What is Apilast?
Apilast is an oral prescription medicine used for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate. It is a phosphodiesterase 4 (PDE-4) inhibitor.
What is the mechanism of action for Apilast?
Apilast works by inhibiting the release of pro-inflammatory mediators involved in plaque psoriasis. It also serves to inhibit T-lymphocyte activation, which helps reduce the inflammatory response.
What are the side effects of Apilast?
The most common side effects associated with Apilast include nausea, headache, diarrhoea, upper respiratory tract infection, abdominal pain, fatigue, nasopharyngitis and depression.
Is Apilast approved for the treatment of psoriatic arthritis?
Yes, Apilast is approved for the treatment of psoriatic arthritis in addition to plaque psoriasis.
How long does a treatment course of Apilast last?
The duration of treatment with Apilast depends on a variety of factors, including the severity of the condition, the response to treatment, and other concurrent medications. Generally, it is recommended that a patient remain on the therapy for at least 3 to 6 months before a proper assessment can be made.
What is the recommended dosage for Apilast?
The recommended dosage of Apilast is 30mg taken orally twice daily with or without food.
Is Apilast considered safe?
Yes, Apilast has been studied extensively in clinical trials and has been approved by the FDA. It is considered a safe and effective treatment for plaque psoriasis and psoriatic arthritis.
Can Apilast be used in combination with other medications?
Yes, Apilast can be used in combination with other medications such as topical corticosteroids and vitamin D derivatives for the treatment of plaque psoriasis.
Is Apilast effective in treating psoriasis?
Yes, Apilast has been shown to be effective in treating plaque psoriasis in clinical trials. Up to 45% of patients treated with Apilast achieved at least a 75% improvement in their symptoms, compared to 25% of patients treated with placebo.
What is the typical duration of treatment with Apilast?
The treatment duration of Apilast depends on individual patient factors as described above. Generally, it is recommended that treatment is continued until there is a significant improvement in the symptoms and signs of the disease. Treatment should be continued until any disease flare-ups are under control.
Does Apilast cause any serious side effects?
Apilast has been studied extensively in clinical trials and is generally considered to be well-tolerated. However, there may be serious side effects associated with Apilast, such as depression, increased risk of infections, and liver problems. Please consult with your doctor if you have any concerns or questions.
Is Apilast a safe option for long-term management of psoriasis?
Yes, Apilast has been studied extensively in clinical trials and is generally considered to be safe and well-tolerated for long-term use. However, it is important to note that the potential risks and side effects should be discussed with your doctor before starting treatment.
Does Apilast interact with other medications?
Yes, Apilast may interact with certain medications, including non-steroidal anti-inflammatory drugs (NSAIDs) and anticoagulants. It is important to discuss any medications you are currently taking with your doctor before starting treatment with Apilast.
How long does it take for Apilast to start working?
The effects of Apilast may vary from person to person. Generally, it can take up to 12 weeks for the effects of Apilast to be seen. If no significant improvement is seen after this time period, your doctor may suggest a change in treatment.
What is the cost of Apilast?
The cost of Apilast can vary depending on a variety of factors, including insurance coverage. It is important to speak to your doctor and insurance provider to determine the exact cost of your treatment.
Can Apilast be used during pregnancy?
No, Apilast is not recommended for use during pregnancy. Animal studies suggest that there may be risks to the fetus, so it is important to discuss any pregnancy or plans for pregnancy with your doctor before starting treatment.
How should Apilast be stored?
Apilast should be stored in a cool, dry place and away from direct light. It should also be kept out of reach of children.
Can I donate blood while taking Apilast?
It is recommended that you do not donate blood while taking Apilast due to the potential for the drug to be passed to other individuals through the use of donated blood.
Is Apilast available in generic form?
No, Apilast is not currently available in generic form.
Can Apilast be taken with food?
Yes, Apilast can be taken with food.
Does Apilast help with itching from psoriasis?
Yes, Apilast has been shown to be effective in reducing itching associated with psoriasis.
Does Apilast cause weight gain?
Apilast has not been shown to be associated with weight gain in clinical trials. However, it is important to discuss any changes in weight with your doctor.
Is Apilast covered by insurance?
Yes, Apilast is typically covered by most insurance plans. It is important to check with your insurance provider to determine specifics of your coverage.
How should Apilast be taken?
Apilast should be taken orally twice daily with or without food. It is important to take the medicine as prescribed and not to increase or decrease the dose without consulting your doctor.
Is Apilast safe for children?
Apilast is not recommended for use in children. It is important to consult with your doctor before starting any medication for children.
Does Apilast cause hair loss?
No, Apilast has not been shown to cause hair loss in clinical trials.
Can Apilast be used in combination with topical medications?
Yes, Apilast can be used in combination with topical medications such as corticosteroids and vitamin D derivatives.
What should I do if I miss a dose of Apilast?
It is important to take Apilast as prescribed by your doctor. If you miss a dose, it is recommended to take the missed dose as soon as possible. However, it is important not to take more than two doses in one day.
Can Apilast be used in combination with biologic medications?
Yes, Apilast can be used in combination with biologic medications such as adalimumab or etanercept, though careful monitoring is recommended.
Does Apilast increase the risk of infection?
Yes, Apilast may increase the risk of infection. It is important to discuss any potential risks with your doctor before starting treatment.
What is the most common adverse effect of Apilast?
The most common adverse effect of Apilast is nausea.
Is Apilast approved for the treatment of other skin disorders?
No, Apilast is not approved for the treatment of other skin disorders. It is only approved for the treatment of plaque psoriasis and psoriatic arthritis.
Does Apilast cause liver damage?
The use of Apilast has been associated with an increased risk of liver damage. It is important to discuss any potential risks with your doctor before starting treatment.
Is Apilast available in other forms besides tablets?
No, Apilast is only available as an oral tablet.
Can Apilast be used in combination with systemic medications?
Yes, Apilast can be used in combination with other systemic medications such as methotrexate or cyclosporine.
Does Apilast interact with any herbal supplements?
Yes, Apilast may interact with certain herbal supplements. It is important to discuss any supplements you are taking with your doctor before starting treatment.
Can Apilast be used in combination with phototherapy?
Yes, Apilast can be used in combination with phototherapy.
What should I do if I experience any adverse effects while taking Apilast?
It is important to speak to your doctor if you experience any adverse effects while taking Apilast. Your doctor may decide to adjust your dose or switch to another treatment.
Does Apilast cause dizziness?
Yes, Apilast may cause dizziness. It is important to discuss any potential risks with your doctor before starting treatment.
Does Apilast cause an increase in blood pressure?
Apilast has not been shown to be associated with an increase in blood pressure in clinical trials. However, it is important to discuss any changes in blood pressure with your doctor.
Does Apilast cause gastrointestinal issues?
Yes, Apilast may cause gastrointestinal issues such as nausea, diarrhoea, and abdominal pain.
Can Apilast be used with other psoriasis treatments?
Yes, Apilast can be used in combination with various other psoriasis treatments such as topical medications, systemic medications, and phototherapy.
Can Apilast be used with topical tacrolimus?
Yes, Apilast can be used in combination with topical tacrolimus.