|Brand Name:||Apicon 50|
|Therapeutic Class:||Drugs for cutaneous mycoses, Drugs for subcutaneous and systemic mycoses|
|Manufacturer:||APC Pharma Ltd.|
|Last Updated:||2020-11-22 18:15:00|
Apicon 50 Capsule contains Fluconazole. Apicon 50 uses:
Fluconazole is indicated in
Apicon 50 Capsule contains Fluconazole 50 mg. Apicon 50 doses:
Adult & child:
Invasive candidal infections including candidaemia and disseminated candidiasis and cryptococcal infections including meningitis, by IV, 400 mg initially then 200 mg daily, increased if necessary to 400 mg daily, treatment continued according to response (at least 6-8 weeks for cryptococcal meningitis); Child 6-12 mg/kg daily (every 72 hours in neonate up to 2 weeks old, every 48 hours in neonate 2-4 weeks old); maximum 400 mg daily.Prevention of relapse of cryptococcal meningitis, by IV, 100-200 mg daily.
Since oral absorption is rapid and almost complete, the daily dose of Fluconazole is the same for oral and intravenous administration.
Therapy with Fluconazole is well tolerated. The common adverse effects are nausea. abdominal pain, vomiting, diarrhoea, headache and skin rash.
Fluconazole is the first of a new subclass of synthetic triazole antifungal agent which acts by inhibition of the ergosterol component of the fungal cell membrane. It is active against a broad spectrum of fungal pathogens and is available for oral use.
Caution should be taken in renal impairment, pregnancy and breast feeding and in raised liver enzymes. The use of Fluconazolein lactating mothers is not recommended.
Rifampicin reduces plasma concentration of Fluconazole. Fluconazole enhances the effect of nicoumalone, warfarin and phenytoin. It also increases the plasma concentration of sulphonylureas & theophlline.
Use in pregnancy: Fluconazole should be used in pregnancy only if the potential benefit justifies the possible risk to the foetus.Use in lactation: Fluconazole is secreted in human milk at concentrations similar to plasma. Therefore, the use of Flouconazole in nursing mother is not recommended.
Fluconazole is contraindicated to patients hypersensitive to this drug and in advanced liver disease.
Store below 30° C. Protect from light & moisture. Remaining reconstituted suspension should not be used after 7 days. If it is kept under freezing temperature (2- 8° C) , it can be used for 14 days. Keep out of the reach of children.
In the case of an overdose, supportive measures should be instituted.
Apicon 50 Capsule price in Bangladesh 11.20