Antrenyl

Antrenyl Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Antrenyl is a brand name. Its generic name is Oxyphenonium.

Introduction

Antrenyl is used to treat certain bladder conditions, such as urge incontinence (uncontrolled leakage of urine during normal activities) and spastic bladder (overactive bladder). It is a medication that relaxes the muscles of the bladder neck and bladder and makes it easier to pass urine in patients with these conditions.

Uses of Antrenyl

Antrenyl is used to treat urge incontinence (moderate to severe) and spastic bladder (overactive bladder). It can also be used to treat other bladder conditions, such as urinary incontinence due to multiple sclerosis, as well as detrusor instability or detrusor-sphincter dyssynergia.

Mechanism of Action

Antrenyl works by relaxing the muscles surrounding the bladder and thereby allowing the bladder to fill and distend more, which reduces the urge to urinate or the frequency of urination. This relaxant action also reduces the spasticity of the bladder muscles, which often results in improved control of bladder function.

How Long Does It Take to Work?

The effects of oxyphenonium may be experienced after the first dose, however, it may take a few days for the full effect to be achieved. The effects of oxyphenonium usually last 4 to 6 hours.

Absorption and Route of Elimination

Antrenyl is rapidly absorbed after oral administration and primarily eliminated via the kidneys in the urine as an unchanged drug.

Dosage

The recommended dose of oxyphenonium for most patients is one 5 mg tablet taken four times daily. Patients with severe cases of urinary incontinence may require up to 10 mg tablets taken four times daily.

Administration

Antrenyl tablets should be taken with meals and/or with a full glass of water to increase absorption and reduce the incidence of side effects. The tablets can be taken with or without food.

Side Effects

The most common side effects of oxyphenonium are dry mouth, constipation, nausea, dizziness, headache, drowsiness, blurred vision, and increased heart rate.

Toxicity

Antrenyl is generally well tolerated. The most common side effects are mild and transient. Overdoses of oxyphenonium may result in seizures and coma. It is important to seek medical attention immediately if an overdose is suspected.

Precautions

Antrenyl should be used with caution in patients with conditions such as cardiac or renal impairment, hypertension, diabetes, depression, glaucoma, or thyroid disorders. It is important to discuss your medical history with your healthcare provider before starting oxyphenonium.

Interactions

Antrenyl may interact with certain medications such as non-steroidal anti-inflammatory drugs, alcohol, and certain anticholinergics. It is important to inform your healthcare provider of all the medications you are taking before starting oxyphenonium.

Disease Interactions

Antrenyl may interact with certain disease states such as unstable heart disease, coronary artery disease, renal impairment, severe hepatic impairment, and myasthenia gravis. Tell your healthcare provider your medical history before starting oxyphenonium.

Drug Interactions

Antrenyl may interact with certain medications such as non-steroidal anti-inflammatory drugs (NSAIDs), alcohol, and certain anticholinergics. It is important to inform your healthcare provider of all the medications you are taking before starting oxyphenonium.

Food Interactions

Antrenyl is not affected by food. However, it is important to take the medication with meals and/or with a full glass of water to reduce the risk of side effects.

Pregnancy Use

Antrenyl should not be used in pregnancy unless the potential benefits justify the potential risk to the fetus. It is important to discuss the risks and benefits of taking oxyphenonium with your healthcare provider.

Lactation Use

Antrenyl should be avoided in breastfeeding women, as it is not known if the drug will pass into the breast milk and cause harm to the infant. It is important to discuss the risks and benefits with your healthcare provider before taking oxyphenonium.

Acute Overdose

The most common symptoms of an overdose of oxyphenonium are nausea, vomiting, sedation, agitation, confusion, hypotension, seizures and coma. If an overdose is suspected, seek medical attention immediately.

Contraindication

Antrenyl should not be used in patients with known hypersensitivity or allergy to the drug. It should also not be used in patients with urinary tract obstruction, paralytic ileus, or glaucoma, as these conditions may worsen with treatment.

Use Directions

Antrenyl should be taken as directed by your healthcare provider. The recommended dose is one 5 mg tablet taken four times daily. Patients with severe cases of urinary incontinence may require up to 10 mg tablets taken four times daily.

Storage Condition

Antrenyl tablets should be stored at room temperature and away from moisture and direct sunlight. Keep the tablets in a tightly closed container. Do not store near heat or open flame.

Volume of Distribution

The volume of distribution of oxyphenonium is not well established. It is believed that the drug is distributed throughout the body tissues.

Half Life

The half-life of oxyphenonium is approximately 4 to 6 hours. This is the time it takes for the drug to be reduced by half in the body.

Clearance

Antrenyl is rapidly cleared from the body by the kidneys. It is estimated that up to 55% of the drug is cleared in this manner.

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