|Therapeutic Class:||Respiratory viral infections (Influenza)|
|Last Updated:||2020-11-21 18:15:00|
Antiflu Capsule contains Oseltamivir. Antiflu uses:
Antiflu Capsule is indicated for prevention of flu (influenza) in adults and adolescents aged 13 years and over who have been in contact with someone diagnosed with flu; treatment of flu (influenza) in adults and in children over one year of age when the influenza virus is circulating in the community
Antiflu Capsule contains Oseltamivir 75 mg. Antiflu doses:
Antiflu Capsule Phosphate may be taken with or without food. However, when taken with food, tolerability may be enhanced in some patients.Standard oral dose for the treatment of influenza:
Recommended oral dose for the treatment of influenza:
May be taken with or without food. May be taken with meals to reduce GI discomfort. Cap may be opened & mixed with sweetened food products eg chocolate syr, sweetened condensed milk, apple sauce or yogurt. Swallow mixture immediately after preparation.
The most frequently reported adverse events are nausea and vomiting. These events generally of mild to moderate degree and usually are occurred on the first 2 days of administration. Additional adverse events occurring in <1% of patients receiving Antiflu Capsule for treatment include unstable angina, anemia, pseudomembranous colitis, humerus fracture, pneumonia, pyrexia, and peritonsillar abscess.
Antiflu Capsule is a prodrug of oseltamivir carboxylate. Antiflu Capsule carboxylate inhibits neuraminidase (sialidase), a viral surface enzyme which is responsible for the replication and infectivity of influenza virus A and B, thereby preventing the release of viruses from infected cells.
There is no evidence for efficacy of Antiflu Capsule Phosphate in any illness caused by agents other than influenza viruses Types A and B. Efficacy of Antiflu Capsule Phosphate in patients who begin treatment after 40 hours of symptoms has not been established.
Information derived from pharmacology and pharmacokinetic studies of Antiflu Capsule suggests that clinically significant drug interactions are unlikely. Co-administration with amoxicillin does not alter plasma levels of either compound.
Pregnancy Category C: There are insufficient human data upon which to base an evaluation of risk of Antiflu Capsule Phosphate to the pregnant woman or developing fetus.
Nursing Mothers: It is not known whether oseltamivir or oseltamivir carboxylate is excreted in human milk. Antiflu Capsule Phosphate should, therefore, be used only if the potential benefit for the lactating mother justifies the potential risk to the breast-fed infant.
Antiflu Capsule is contraindicated in patients with known hypersensitivity to any of the components of the product.
Hepatic Impairment: The safety and pharmacokinetics in patients with hepatic impairment have not been evaluated.
Renal Impairment: Dose adjustment is recommended for patients with a serum creatinine clearance <30 mL/min.
Geriatric Use: The safety of Antiflu Capsule Phosphate has been established in clinical studies.
Pediatric Use: The safety and efficacy of Antiflu Capsule Phosphate in pediatric patients younger than 1 year of age have not been studied. Antiflu Capsule Phosphate is not indicated for either treatment or prophylaxis of influenza in pediatric patients younger than 1 year of age.
At present there has been no experience of over dose. Single dose of up to 1000 mg of Antiflu Capsule have been associated with nausea and/or vomiting.
Store at 25°C. Reconstituted susp: Store between 2-8°C for up to 17 days or at 25°C for up to 10 days. Do not freeze.
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