Anasec IV Injection

Brand Name: Anasec
Generic: Omeprazole
Weight: 40 mg/vial
Type: IV Injection
Therapeutic Class: Proton Pump Inhibitor
Manufacturer: Novo Healthcare and Pharma Ltd.
Price: 98.00
Last Updated: 2020-11-21 18:15:00
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Anasec IV Injection Uses

Anasec IV Injection contains Omeprazole. Anasec uses:

Anasec IV Injection offers significant therapeutic gains in the treatment of acid related diseases. Healing rates are high in duodenal ulcer, gastric ulcer and erosive reflux oesophagitis; acid production is controlled effectively in Zollinger-Ellison Syndrome and symptom relief is prompt and sustained in all indications. Less clear-cut indications where benefit might be expected but where data are limited include:

  • Prevention of stress ulceration
  • Prevention of the acid aspiration syndrome
  • Treatment of upper gastro-intestinal bleeding

NOTE: In comparative studies, Anasec IV Injection has been found to produce faster symptom relief and higher healing rates in a greater percentage of patients than either Cimetidine or Ranitidine, confirming the ‘therapeutic gains’ achievable with Anasec IV Injection over existing therapies.

Anasec IV Injection Doses

Anasec IV Injection contains Omeprazole 40 mg/vial. Anasec doses:

Oral-

Duodenal Ulcer: 20 mg once daily for 4 weeks. In severe cases, 40 mg once daily for 4 weeks.

Gastric Ulcer: 20 mg once daily for 8 weeks. In severe cases, 40 mg once daily for 8 weeks.

Erosive Reflux Oesophagitis: 20 mg once daily for 4 weeks. For those not fully healed, to be continued for 4 more weeks. Refractory Reflux Oesophagitis: 40 mg once daily for 8 weeks. Zollinger-Ellison Syndrome: 60 mg once daily, adjusted individually and continued as long as necessary.Most patients will be effectively controlled with 20-120 mg daily. Dosage above 80 mg should be divided and given twice daily. Long-term maintenance treatment with Anasec IV Injection is not recommended.

Impaired Renal or Hepatic Function: Adjustment is not required. Patients with severe liver disease should not require more than 20 mg Anasec IV Injection daily

IV Injection-

Prophylaxis of acid aspiration: Anasec IV Injection 40 mg to be given slowly (over a period of 5 minutes) as an intravenous injection, one hour before surgery.

Duodenal ulcer, gastric ulcer or reflux oesophagitis: In patients with duodenal ulcer, gastric ulcer or reflux oesophagitis where oral medication is inappropriate, Anasec IV Injection IV 40 mg once daily is recommended.

Zollinger- Ellison syndrome (ZES): In patients with Zollinger-Ellison Syndrome the recommended initial dose of Anasec IV Injection given intravenously is 60 mg daily. Higher daily doses may be required and the dose should be adjusted individually. When doses exceed 60 mg daily, the dose should be divided & given twice daily.

Powder for suspension: Should be taken on an empty stomach. Take at least 1 hr before a meal.

Capsule or Tablet: Should be taken with food. Take immediately before a meal. Patients should be cautioned that the capsules should not be opened, chewed or crushed and should be swallowed whole.

Delayed release Capsule or Tablet: Should be taken on an empty stomach. Take at least 1 hr before meals. Swallow whole, do not chewithcrush. For patients with difficulty swallowing, cap may be carefully opened & entire contents sprinkled in a spoonful of applesauce. Swallow drug/food mixt witho chewing immediately after prep. Drug/food mixt should not be stored for future use.

IV Injection: Anasec IV Injection lyophilized powder and water for injection is for intravenous administration only and must not be given by any other route. Anasec IV Injection IV injection should be given as a slow intravenous injection. The solution for IV injection is obtained by adding 10 ml water for injection to the vial containing powder. After reconstitution the injection should be given slowly over a period of at least 2 to 5 minutes at a maximum rate of 4 ml/minute. Use only freshly prepared solution. The solution should be used within 4 hours of reconstitution.

IV Infusion: Anasec IV Injection IV infusion should be given as an intravenous infusion over a period of 20-30 minutes or more. The contents of one vial must be dissolved in 100 ml saline for infusion or 100 ml 5% Dextrose for infusion. The solution should be used within 12 hours when Anasec IV Injection is dissolved in saline and within 6 hours when dissolved in 5% Dextrose. The reconstituted solution should not be mixed or co-administered in the same infusion set with any other drug.

Side Effects

Side effects reported with Anasec IV Injection in clinical studies have included nausea, diarrhoea, constipation, flatulence, abdominal colic, paresthesia, dizziness and headache but are rare. Skin rashes, leukopenia and transient elevation of plasma activation of hepatic amino-transferases have been observed occasionally in few patients and there has been no consistent relationship with treatment.

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Introduction

Anasec IV Injection belongs to a class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, omeprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus.

Anasec Precaution

Precautions: Symptomatic response to therapy with Anasec IV Injection does not preclude the presence of gastric malignancy.

Warning: In long-term (2 years) studies in rats, Anasec IV Injection produced a dose related increase in gastric carcinoid tumours. While available endoscopic evaluations and histologic examinations of biopsy specimens from human stomachs have not detected a risk from short-term exposure to Anasec IV Injection, further human data on the effects of sustained hypochlorhydria and hypergastrinemia are needed to rule out the possibility of an increased risk for the development of tumours in humans receiving long-term therapy with Anasec IV Injection.

Interaction

Anasec IV Injection can delay the elimination of Diazepam, Phenytoin and Warfarin. Monitoring of patients receiving Warfarin or Phenytoin is recommended and a reduction of Warfarin or Phenytoin dose may be necessary when Anasec IV Injection is added to treatment. Anasec IV Injection does not interfere with Theophylline or Propranolol metabolism.

Pregnancy Lactation use

Pregnancy: There are no adequate and well-controlled studies on the use of Anasec IV Injection in pregnant women. Therapeutic doses during pregnancy are unlikely to pose a substantial teratogenic risk. Anasec IV Injection should be used during pregnancy only if the potential benefit to pregnant women justifies the potential risk to the fetus.

Lactation: Anasec IV Injection is excreted in human milk. Thus, a decision should be taken to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Contraindication

Anasec IV Injection is contraindicated in patients with known hypersensitivity to any component of the formulation.

Special Warning

Renal Impairment: No dosage adjustment needed

Hepatic Impairment: 10-20 mg/day

Pediatric Use: Safety and effectiveness in children have not been established

Acute Overdose

Symptoms were transient, and no serious clinical outcome has been reported with Anasec IV Injection overdose. No specific antidote for Anasec IV Injection overdose is known. Anasec IV Injection is extensively bound with protein and is, therefore, not readily dialyzable. In the event of overdose, treatment should be symptomatic and supportive.

Interaction with other Medicine

 

Storage Condition

Store in a cool and dry place. Keep out of the reach of children.

Anasec IV Injection price in Bangladesh 98.00

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