Amlodipine

Amlodipine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Amlodipine is a brand name. Its generic name is Amlodipine.

Amlodipine Introduction

Amlodipine is a prescription medication used to treat high blood pressure (hypertension) and chest pain (angina). It belongs to a group of drugs called calcium channel blockers, which work by relaxing the muscles of the heart and blood vessels. It can be taken by adults and children age 6 years and older.

Uses for Amlodipine

Amlodipine is used to treat high blood pressure (hypertension) and chest pain (angina). It works by relaxing the muscles of the heart and blood vessels, resulting in lower blood pressure and improved circulation. It can be taken by adults and children age 6 years and older.

Mechanism of Action

Amlodipine works by blocking the action of calcium on the muscles of the heart and blood vessels. This results in lower blood pressure and improved circulation. The exact mechanism of how it works is not fully understood.

How Long Does it Take to Work?

Amlodipine typically takes about 2 weeks to begin working to lower blood pressure. The full effects of the medication may not be seen until after 3 to 4 weeks of treatment. It is important to keep taking the medication as prescribed to achieve the full benefits of the medication.

Absorption

Amlodipine is absorbed rapidly from the gastrointestinal tract after oral administration.

Route of Elimination

Amlodipine is eliminated primarily through metabolism and excretion of its metabolites in the urine and feces.

Dosage

The recommended starting dose for adults and children 6 years and older is 2.5 to 5 mg by mouth once daily. Your doctor may increase or decrease your dose depending on your response to treatment. Do not change your dose on your own without talking to your doctor first.

Administration

Amlodipine should be taken with a full glass of water, with or without food. It is important to take it at the same time each day to maintain an even level of the medication in the body.

Side Effects

Common side effects of Amlodipine may include nausea, constipation, dizziness, headache, fatigue and flushing. Other side effects may also occur. Talk to your doctor if you experience any side effects during treatment.

Toxicity

Amlodipine is generally well-tolerated, but overdosing can cause serious side effects or even death. Symptoms of overdose may include slow heart rate, low blood pressure, and confusion. If you believe you or someone you know may have taken an overdose, contact a poison control center or seek emergency medical attention right away.

Precautions

Before taking Amlodipine, tell your doctor if you have liver or kidney disease, low blood pressure, heart problems, if you are pregnant or breastfeeding, or if you are taking any other medications. Do not stop taking Amlodipine without talking to your doctor first.

Interaction

Certain medications, such as diuretics, antidepressants, and beta-blockers, can interact with Amlodipine. Tell your doctor if you are taking any other medications.

Disease Interaction

Amlodipine can worsen certain conditions, such as heart failure. Tell your doctor if you have or have ever had heart disease, diabetes, or other medical conditions.

Drug Interaction

Certain medications, such as diuretics, antidepressants, and beta-blockers, can interact with Amlodipine. Tell your doctor if you are taking any other medications.

Food Interaction

Amlodipine may interact with certain foods, such as grapefruit juice. Ask your doctor or pharmacist if it is safe to drink grapefruit juice while taking Amlodipine.

Pregnancy Use

Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the unborn baby. Talk to your doctor about the risks and benefits of taking Amlodipine during pregnancy.

Lactation Use

Amlodipine is excreted in breast milk. Talk to your doctor before taking Amlodipine if you are breastfeeding.

Acute Overdose

Symptoms of an acute overdose may include slow heartbeat, low blood pressure, and confusion. If you believe you or someone you know may have taken an overdose, contact a poison control center or seek emergency medical attention right away.

Contraindication

Amlodipine should not be used in people with severely decreased liver or kidney function, or those allergic to amlodipine or other calcium channel blockers.

Use Direction

Amlodipine should be taken as directed by your doctor. The recommended starting dose for adults and children 6 years and older is 2.5 to 5 mg by mouth once daily. Your doctor may increase or decrease your dose depending on your response to treatment. Do not change your dose on your own without talking to your doctor first.

Storage Condition

Store at room temperature away from moisture and heat. Keep away from children.

Volume of Distribution

The volume of distribution for Amlodipine is 0.24 L/kg.

Half-Life

The half-life of Amlodipine is 24 to 54 hours.

Clearance

The clearance of Amlodipine is 0.12 L/hr/kg.

Here you find in details version of Amlodipine

Some Frequently Asked Questions About Amlodipine

What is Amlodipine?

Amlodipine is a type of prescription medicine called a calcium channel blocker. It is used to treat high blood pressure and chest pain caused by angina.

What are the side effects of Amlodipine?

Side effects of Amlodipine can include headache, dizziness, tiredness, flushing, nausea, stomach pain, rash, and swelling. Other rare side effects can include swelling of the gums, increased urination, and difficulty breathing.

What is the usual dose of Amlodipine?

The usual dose of Amlodipine for adults is 5 mg to 10 mg taken once a day. The maximum daily dose is 10 mg.

Can I take Amlodipine with other medications?

Yes, it is possible to take Amlodipine with other medications. However, it is important to speak to your doctor about any medications you are taking before adding Amlodipine to your routine.

Is Amlodipine safe for pregnant women?

Amlodipine is not recommended for pregnant women as there have been reports of fetal side effects. Women who are pregnant or planning to become pregnant should consult their doctor before taking Amlodipine.

What are the common uses of Amlodipine?

Amlodipine is commonly used to treat high blood pressure (hypertension) and chest pain brought on by angina. It can also be used to prevent certain types of chest pain in adults and improve blood flow to the heart.

What should I do if I forget to take my dose of Amlodipine?

If you forget to take your dose of Amlodipine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and carry on as normal. Do not take a double dose to make up for a forgotten one.

What should I do if I accidentally overdose on Amlodipine?

If you take too much Amlodipine, you may experience side effects such as lightheadedness, dizziness, chest pain or an irregular heartbeat. If this occurs, you should seek medical attention right away.

Does Amlodipine cause weight gain?

Weight gain is not a common side effect of Amlodipine. However, it is possible to gain weight while taking Amlodipine, mostly due to other factors such as diet and lifestyle.

Can Amlodipine be used to treat other conditions?

Amlodipine is usually used to treat high blood pressure and chest pain caused by angina. However, it may be used off-label to treat other conditions such as Raynaud's phenomenon and chronic kidney disease.

What is the long-term outlook for people taking Amlodipine?

Amlodipine is generally well tolerated and safe for long-term use. Side effects are usually mild and manageable. It is important to speak with your doctor about any concerns you may have regarding long-term use of Amlodipine.

Can Amlodipine be used in children?

Amlodipine is not usually recommended for use in children. There is limited data to suggest that Amlodipine may be used in children, however, this should be discussed with a doctor.

What should I do if I experience side effects while taking Amlodipine?

If you experience any side effects while taking Amlodipine, you should speak to your doctor. Your doctor may wish to adjust the dosage or switch to an alternative medication.

Does Amlodipine interact with other medications?

Yes, Amlodipine can interact with other medications. It is important to tell your doctor about any medication you are taking before taking Amlodipine.

Does Amlodipine cause sleepiness?

Sleepiness is not a common side effect of Amlodipine. However, some people may experience drowsiness or fatigue while taking Amlodipine.

Can Amlodipine be used to treat hypertension?

Yes, Amlodipine is used to treat hypertension in adults. It is usually taken once daily to lower blood pressure and prevent chest pain caused by Angina.

Is Amlodipine safe for elderly patients?

Amlodipine is generally safe for elderly patients. However, elderly patients may be more likely to experience side effects such as dizziness, fatigue, or confusion.

Can Amlodipine be taken with alcohol?

It is not recommended to take Amlodipine with alcohol as alcohol can increase the risk of side effects. It is always important to consult your doctor before drinking alcohol with any medication.

Does Amlodipine cause dizziness?

Dizziness is a common side effect of Amlodipine. If you experience dizziness, it is advisable to avoid activities such as driving or operating machinery until the effects have worn off.

Can Amlodipine cause a rash?

Yes, a rash is a possible side effect of Amlodipine. It is important to speak to a doctor if you experience a rash while taking Amlodipine.

Can Amlodipine be taken with other blood pressure medications?

Yes, it is possible to take Amlodipine with other blood pressure medications. However, it is important to speak to your doctor about any medications you are taking before taking Amlodipine.

Does Amlodipine cause headaches?

Headaches are a common side effect of Amlodipine. If you experience headaches, it is advisable to speak to your doctor.

Does Amlodipine cause nausea?

Nausea is a common side effect of Amlodipine. If you experience nausea, it is advisable to speak to your doctor.

Can Amlodipine cause constipation?

Yes, constipation is a possible side effect of Amlodipine. If you experience constipation, it is advisable to speak to your doctor.

Does Amlodipine interact with grapefruit?

Yes, it is possible for Amlodipine to interact with grapefruit. It is important to speak to a doctor before eating grapefruit if you are taking Amlodipine.

What is the best time of day to take Amlodipine?

It is recommended to take Amlodipine once a day at the same time each day. Your doctor or pharmacist can advise you on the best time of day for you to take your dose.

Are there any other calcium channel blockers available?

Yes, there are other calcium channel blockers available. Other calcium channel blockers include Diltiazem, Verapamil, Felodipine, and Nifedipine.

What should I do if I experience an allergic reaction to Amlodipine?

If you experience any signs of an allergic reaction while taking Amlodipine, such as an itchy rash, swelling of the face, lips, or tongue, or difficulty breathing, discontinue use immediately and seek medical attention right away.

How long should I take Amlodipine for?

Amlodipine is usually taken long-term, so you can expect to take the medication for an extended period of time. It is important to talk to your doctor about the duration of your treatment and any changes to your medication.

Is Amlodipine addictive?

Amlodipine is not an addictive medication. However, it is important to follow your doctor's instructions for taking the medication.

Can Amlodipine be used to treat high cholesterol?

No, Amlodipine is not used to treat high cholesterol. If you are looking to lower your cholesterol, speak to your doctor about medications and lifestyle changes that can help.

Can Amlodipine be used to treat a heart attack?

No, Amlodipine is not used to treat a heart attack. If you are experiencing a heart attack, seek emergency medical attention right away.

Does Amlodipine cause hair loss?

Hair loss is not a common side effect of Amlodipine. However, some people may experience alopecia while taking the medication.

Can Amlodipine cause dizziness when getting up from a sitting or lying position?

Yes, it is possible for Amlodipine to cause dizziness when getting up from a sitting or lying position. If this occurs, it is advisable to stand up slowly and speak to your doctor

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Can Amlodipine cause anxiety?

Anxiety is not a common side effect of Amlodipine. However, some people may experience anxiety while taking the medication.

Can Amlodipine cause dry mouth?

Yes, dry mouth is a possible side effect of Amlodipine. If you experience dry mouth, it is advisable to drink plenty of fluids and speak to your doctor.

Can Amlodipine cause blurred vision?

Yes, blurred vision is a possible side effect of Amlodipine. If you experience blurred vision while taking Amlodipine, it is important to speak to your doctor.

Does Amlodipine cause fatigue?

Fatigue is a common side effect of Amlodipine. If you experience fatigue, it is advisable to speak to your doctor.

Are there any foods to avoid while taking Amlodipine?

It is advisable to avoid grapefruit and grapefruit juice while taking Amlodipine as this can increase the risk of side effects. It is also important to eat a healthy, balanced diet and avoid foods high in sodium or fat.

Can Amlodipine cause liver damage?

Liver damage is not a common side effect of Amlodipine. However, some people may experience elevated liver enzyme levels while taking the medication. If this occurs, it is important to consult your doctor.