Amizide Tablet

Brand Name: Amizide
Generic: Hydrochlorothiazide + Amiloride
Weight: 50 mg+5 mg
Type: Tablet
Therapeutic Class: Thiazide diuretics & related drugs
Manufacturer: Sanofi Bangladesh LTD.
Price: 1.01
Last Updated: 2020-11-20 18:15:00
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Amizide Tablet Uses

Amizide Tablet contains Hydrochlorothiazide + Amiloride. Amizide uses:

Treatment of hypertension or congestive heart failure in patients who develop hypokalemia when thiazide or other kaliuretic diuretics are used alone, or in patients in whom maintenance of normal serum potassium levels is clinically important (eg, digitalized patients); alone or as adjunctive treatment with other antihypertensive agents.

Amizide Tablet Doses

Amizide Tablet contains Hydrochlorothiazide + Amiloride 50 mg+5 mg. Amizide doses:

Adult: 1-2 tablets (5 mg amiloride & 50 mg hydrochlorothiazide) daily in single or divided doses, increasing if necessary to maximum 4 tablets.

Children: Safety and efficacy not established.

 

Side Effects

  • Cardiovascular: Arrhythmia, tachycardia, palpitations (amiloride).
  • CNS: Headache, fatigue, tiredness, weakness, dizziness, encephalopathy, tremors, decreased libido (amiloride); restlessness (hydrochlorothiazide).
  • Dermatologic: Mild skin rash, pruritus, alopecia (amiloride); urticaria, purpura (hydrochlorothiazide).
  • EENT (eye, ear, nose, and throat): Increased ocular pressure, tinnitus (amiloride); transient blurred vision, xanthopsia (hydrochlorothiazide).
  • GI: Nausea, anorexia, GI and abdominal pain, flatulence, activation of peptic ulcer, dyspepsia, heartburn, dry mouth (amiloride); pancreatitis, cramping, GI irritation, sialadenitis (hydrochlorothiazide).
  • Genitourinary: Bladder spasm, polyuria, urinary frequency (amiloride); interstitial nephritis (hydrochlorothiazide).
  • Hematologic: Aplastic anemia, neutropenia (amiloride); agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia (hydrochlorothiazide).
  • Hepatic: Jaundice.
  • Metabolic: Hyperkalemia, hyperglycemia, glucosuria, hyperuricemia (hydrochlorothiazide).
  • Respiratory: Shortness of breath, cough (amiloride); respiratory distress, including pneumonitis and pulmonary edema (hydrochlorothiazide).
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Introduction

Amiloride is a weak diuretic which acts mainly on the distal renal tubules. It increases the excretion of Na and reduces the excretion of K. It diminishes kaliuretic effects of other diuretics, and may produce an additional natriuretic effect.

Hydrochlorothiazide inhibits the reabsorption of Na in the distal tubules causing increased excretion of Na and water including K and hydrogen ions.

Amizide Precaution

 

Interaction
  • Amiloride ACE inhibitors (eg, captopril): May result in severely elevated potassium levels.
  • Potassium preparations: May severely increase serum potassium levels, possibly resulting in cardiac arrhythmias or cardiac arrest. Do not coadminister.
  • Hydrochlorothiazide Bile acid sequestrants: May reduce thiazide absorption; give thiazide at least 2 h before sequestrant.
  • Diazoxide: May cause hyperglycemia.
  • Digitalis glycosides: Diuretic-induced hypokalemia and hypomagnesemia may lead to digitalis-induced arrhythmias.
  • Lithium: Renal excretion of lithium may be reduced.
  • Loop diuretics (eg, furosemide): Synergistic effects may occur, resulting in profound diuresis and serious electrolyte abnormalities.
  • Sulfonylureas (eg, chlorpropamide): Hypoglycemic effect of sulfonylurea may be decreased, necessitating an increase in sulfonylurea dosage.
Pregnancy Lactation use

Pregnancy Category B 

Lactation: 

  • Amiloride: undetermined
  • hydrochlorothiazide: excreted in breast milk.
Contraindication

Hyperkalemia (serum potassium levels greater than 5.5 mEq/L); concurrently with other potassium-sparing diuretics (eg, spironolactone), potassium supplements (including potassium-rich diet) except in severe or refractory cases of hypokalemia; impaired renal function; sensitivity to any components of product.

Special Warning

 

Acute Overdose

Symptoms: Dehydration, electrolyte imbalance (eg, hyperkalemia), electrolyte depletion (hypokalemia, hypochloremia, hyponatremia).

Interaction with other Medicine

 

Storage Condition

Store tablets at controlled room temperature (59° to 86°F). Protect from moisture, freezing, and excessive heat.

Amizide Tablet price in Bangladesh 1.01

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