Amival F

Amival F Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Amival F is a brand name. Its generic name is Fluphenazine + Nortriptyline.

Introduction

Fluphenazine (also known as Permitil or Prolixin) and Nortriptyline are two medications used for treating mental illness, such as schizophrenia, depression, and bipolar disorder. Fluphenazine is a typical antipsychotic, while Nortriptyline is a tricyclic antidepressant. While both medications are primarily used for treating mental illness, Nortriptyline is sometimes prescribed off-label for treating migraine and chronic neuropathic pain.

Uses

Fluphenazine is typically used to treat schizophrenia, while Nortriptyline is used to treat depression and chronic pain. Fluphenazine's primary use is to control psychotic symptoms, such as delusions, disorganized thinking, agitation, and aggression. Nortriptyline is often used to relieve the symptoms of depression, such as low mood, fatigue, difficulty concentrating, and suicidal thoughts.

Mechanism of Action

Fluphenazine works by blocking dopamine receptors and interfering with the transmission of dopamine throughout the brain. Nortriptyline works by inhibiting the reuptake of norepinephrine and serotonin at the postsynaptic receptor. This increases the available concentration of neurotransmitters in the brain, which can help to improve symptoms of depression.

How Long Does It Take to Work?

The time it takes for Fluphenazine to take effect will vary from person to person, depending on individual metabolism and body weight. Generally, it can take anywhere from one to three weeks for Fluphenazine to take full effect, although some patients may notice some improvement within the first week. Nortriptyline typically takes two to four weeks to take full effect, although some patients may notice some relief of symptoms within the first two weeks.

Absorption

Fluphenazine is generally well absorbed through the gastrointestinal tract, with an oral bioavailability of 90 percent. It has a high volume of distribution in the blood, with an effective half-life of approximately 24-48 hours. Nortriptyline is rapidly absorbed through the gastrointestinal tract with an oral bioavailability of 75-90 percent. It has a low volume of distribution in the blood, with an effective half-life of approximately 15-30 hours.

Route of Elimination

Fluphenazine is mostly eliminated through urine, with a small portion eliminated through feces. Nortriptyline is mainly eliminated through the kidneys, with a small portion eliminated through feces.

Dosage

Fluphenazine is available in tablet, concentrate, and solution form. The usual starting dose for adults is 2.5-5 mg per day, with a maximum of 40mg per day. The starting dose for children ages 8-17 years is 0.5-1.5mg per day, with a maximum of 10mg per day. Nortriptyline is available in tablet form. The usual starting dose for adults is 25-50 mg per day, with a maximum of 150 mg per day. The starting dose for children ages 12-17 is 25mg per day, with a maximum of 50 mg per day.

Administration

Fluphenazine is typically taken two or three times per day. It should be taken with food and/or a full glass of water to reduce the risk of stomach upset. Nortriptyline should be taken with food, preferably at bedtime. It can be taken on an empty stomach or with food.

Side Effects

Common side effects of Fluphenazine include drowsiness, dry mouth, blurred vision, weight gain, restlessness, and dizziness. Nortriptyline can cause drowsiness, dry mouth, constipation, nausea, weight gain, and blurred vision.

Toxicity

Fluphenazine is considered to be safe if used at the prescribed dosage. Overdose of Fluphenazine can result in coma, seizures, and death. Nortriptyline is considered to be safe if taken in its prescribed dosage. Overdose of Nortriptyline can result in coma, seizures, and death.

Precaution

Patients taking Fluphenazine should avoid drinking alcohol, as it can increase the risk of side effects. Fluphenazine can also cause drowsiness, so patients should avoid driving or operating heavy machinery. Patients taking Nortriptyline should not stop taking the medication suddenly, as this can cause withdrawal symptoms or make existing symptoms worse.

Interaction

Fluphenazine and Nortriptyline should not be taken together as they may increase the risk of side effects such as drowsiness, confusion, and dry mouth. The risk of seizure can also be increased if these medications are taken together. Combining Fluphenazine with sedatives, antihistamines, or other drugs that cause drowsiness may increase drowsiness or dizziness. Nortriptyline can also interact with other medications, such as MAO inhibitors, certain antibiotics, other antidepressants, anti-seizure drugs, and seizures.

Disease Interaction

Fluphenazine and Nortriptyline should not be used in patients with a history of myocardial infarction, hypertension, diabetes, or other heart-related illnesses. Fluphenazine should also not be used in patients with a history of epilepsy, seizures, or other seizure-related illnesses. Patients taking either medication should be regularly monitored for changes in heart rate, blood pressure, and cholesterol levels.

Drug Interaction

Fluphenazine and Nortriptyline should not be taken together, as they can interact with certain drugs, such as MAO inhibitors, certain antibiotics, other antidepressants, anti-seizure drugs, and seizure medications. Patients taking these medications should closely monitor for changes in heart rate, blood pressure, and cholesterol levels. Fluphenazine and Nortriptyline can also interact with certain herbs, supplements, and recreational drugs, such as marijuana, cocaine, and alcohol.

Food Interaction

Fluphenazine and Nortriptyline should not be taken with alcohol, as alcohol can increase the risk of side effects. Patients taking either medication should avoid grapefruit juice and grapefruit, as these can interact with Fluphenazine and Nortriptyline and increase the risk of side effects.

Pregnancy Use

Fluphenazine and Nortriptyline should not be taken during pregnancy or while breastfeeding as it may cause harm to the unborn baby or newborn baby. It is highly recommend that pregnant patients speak with their healthcare provider before taking these medications.

Lactation Use

Fluphenazine and Nortriptyline should not be taken while breastfeeding as it may pass through into the breast milk and harm the newborn baby. It is highly recommended that breastfeeding patients speak with their healthcare provider before taking these medications.

Acute Overdose

An acute overdose of Fluphenazine can cause a decrease in blood pressure, cardiac arrhythmia, and coma. An acute overdose of Nortriptyline can cause an increased risk of seizures, coma, and death.

Contraindication

Fluphenazine and Nortriptyline should not be used in patients who are allergic to either medication or its active ingredients. Fluphenazine should not be used in patients with a history of seizures, epilepsy, or other seizure-related illnesses. Nortriptyline should not be used in patients with a history of myocardial infarction, hypertension, diabetes, or other heart-related illnesses.

Use Direction

Fluphenazine and Nortriptyline should be taken as prescribed by a healthcare provider. Fluphenazine should be taken two to three times per day with food and/or a full glass of water. Nortriptyline should be taken once a day with food, preferably at night. The dosage of both medications should be adjusted according to individual response and tolerance.

Storage Condition

Fluphenazine and Nortriptyline should be stored at room temperature in a dry, dark place. Avoid exposing the medications to moisture or sunlight. Keep the medications away from children and pets.

Volume of Distribution

The volume of distribution for Fluphenazine is 14 L/kg. The volume of distribution for Nortriptyline is 2.8-3.8 L/kg.

Half Life

The half life of Fluphenazine is 24-48 hours. The half life of Nortriptyline is 15-30 hours.

Clearance

The clearance of Fluphenazine is 0.884ml/min/kg. The clearance of Nortriptyline is 1.27ml/min/kg.

Here you find in details version of Amival F

Some Frequently Asked Questions About Amival F