Amitriptyline HCl Actavis

Amitriptyline HCl Actavis, a brand name for a formulation containing essential Amitriptyline, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Amitriptyline HCl Actavis, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Amitriptyline HCl Actavis

Amitriptyline HCl Actavis is a tricyclic antidepressant (TCA) medicine that is primarily used to treat depression. It is also commonly used for its pain relief properties. It may be prescribed to people who suffer from chronic pains, arthritic pain, tension headaches, migraine, irritable bowel syndrome, neuropathy, insomnia, and certain anxiety or panic disorders.

Uses for Amitriptyline HCl Actavis

Amitriptyline HCl Actavis is used to treat depression, anxiety, chronic pain, Migraine, irritable bowel syndrome (IBS), tension and cluster headaches, and certain other disorders. It is also prescribed for pain relief due to its analgesic properties. It is also sometimes given in small doses to help people with sleep problems.

Mechanism of Action

Amitriptyline HCl Actavis works by balancing out certain chemicals in the brain that cause depression and mood disorder. It has both an antidepressant effect and a sedative effect. It works by blocking the re-uptake of the chemicals serotonin and norepinephrine that are used to communicate between brain cells. This increases the amount of these chemicals that are available to the brain, thus helping to improve mood.

How Long Does it Take to Work?

Amitriptyline HCl Actavis usually begins to take effect within 3-5 days, though it can take up to two weeks to reach its full effect. The duration of the effect of each dose will depend on the amount taken as well as the individual.


Amitriptyline HCl Actavis is normally well absorbed after oral administration, with a peak plasma concentration occurring around 3-4 hours after ingestion. It has an approximately 50% bioavailability.

Route of Elimination

Amitriptyline HCl Actavis is metabolized in the liver and is then eliminated primarily in the urine. Approximately 30% is excreted unchanged in the urine.


The typical adult starting dose of amitriptyline is 75 mg daily, split into two or three smaller doses. The maximum recommended dose is 300 mg per day. Your doctor may adjust your dosage to achieve the desired therapeutic effect in a safe manner. It is very important to take all medications as prescribed by your doctor.


Amitriptyline HCl Actavis is taken orally, typically 2 to 3 times a day. It can be taken with food or on an empty stomach.

Side Effects

Common side effects of amitriptyline include dry mouth, drowsiness or dizziness, difficulty sleeping, blurred vision, constipation, weight gain, nausea, vomiting, sweating, agitation, and sexual dysfunction.


Amitriptyline HCl Actavis is generally well tolerated, but if taken in excess it can lead to serious side effects, including increased heart rate, confusion, anxiety, and seizures. It can also cause an increase in blood pressure and an irregular heart rate.


Amitriptyline HCl Actavis should not be taken if you are pregnant, breastfeeding, taking other medications that could interact with it, have certain heart conditions, have glaucoma, or are prone to seizures.


Amitriptyline HCl Actavis can interact with several medications, including anti-anxiety drugs, pain medications, sleeping pills, some antihistamines, and muscle relaxants. It is important to talk to your doctor about all possible drug and herb or vitamin interactions before taking amitriptyline.

Disease Interactions

Amitriptyline HCl Actavis can interact with certain diseases, including Parkinson’s disease, glaucoma, and liver or kidney disease. Talk to your doctor about any possible diseases you may have that could affect your use of amitriptyline.

Drug Interactions

Drug interactions may occur with other medications you are taking, including over-the-counter or prescription medications, vitamins, or supplements. Make sure to tell your doctor about all medications you are taking before starting amitriptyline.

Food Interactions

Amitriptyline HCl Actavis may interact with certain foods. Avoid taking amitriptyline with foods or beverages that contain caffeine or high amounts of tyramine. Tyramine is found in mature cheese, aged meats, red wine, and beer. Talk to your doctor about any dietary concerns.

Pregnancy Use

Amitriptyline HCl Actavis should not be taken during pregnancy unless absolutely necessary. It can increase the risk of side effects in both the mother and the baby. Talk to your doctor if you are pregnant or plan to become pregnant before taking amitriptyline.

Lactation Use

Amitriptyline HCl Actavis should not be taken while breastfeeding as it may cause drowsiness and nausea in nursing infants. Talk to your doctor if you are currently breastfeeding before taking amitriptyline.

Acute Overdose

If you think you have taken too much amitriptyline, contact your doctor or the Poison Control Center right away. Symptoms of an overdose may include extreme drowsiness, confusion, sweating, blurred vision, and seizures.


Amitriptyline HCl Actavis should not be used if you are taking an MAOI or are allergic to the drug. People with certain conditions, such as an increased risk of seizures or sinus bradycardia, should also not take amitriptyline.

Use Directions

Amitriptyline HCl Actavis should be taken exactly as prescribed by your doctor. The dose and duration of use will vary depending on individual circumstances. Make sure to follow your doctor's instructions closely.

Storage Condition

Amitriptyline HCl Actavis should be stored at room temperature, away from light and moisture. Make sure to keep this and all other medications out of reach of children.

Volume of Distribution

The volume of distribution of amitriptyline after intravenous administration is approximately 0.6-1.1 L/kg.

Half Life

Amitriptyline HCl Actavis has an elimination half-life of 7-20 hours and an active metabolite half-life of 10-19 hours.


The clearance of amitriptyline is approximately 0.23-0.4 L/h/kg.

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