AmiClean Tablet

Brand Name: AmiClean
Generic: Sodium Thiosulfate
Weight: 7.5 mg
Type: Tablet
Therapeutic Class: Antidote preparations
Manufacturer: Amico Laboratories Ltd.
Price: 0.84
Last Updated: 2020-11-21 18:15:00

AmiClean Tablet Uses

AmiClean Tablet contains Sodium Thiosulfate. AmiClean uses:

Cyanide poisoning

AmiClean Tablet Doses

AmiClean Tablet contains Sodium Thiosulfate 7.5 mg. AmiClean doses:

Adult: To be given after 300 mg of sodium nitrite has been admin over 5-20 min: 12.5 g of sodium thiosulfate (50 ml of a 25% solution or 25 ml of a 50% solution) given over 10 min. Methaemoglobin concentration should not exceed 30-40%. If symptoms of cyanide toxicity recur, the doses of nitrite and thiosulfate may be repeated after 30 min at half the initial doses.

Child: To be given after 4-10 mg/kg of sodium nitrite (max: 300 mg) has been admin: 400 mg/kg of sodium thiosulfate, as a 25 or 50% solution (max: 12.5 g). Methaemoglobin concentration should not exceed 30-40%. If symptoms of cyanide toxicity recur, the doses of nitrite and thiosulfate may be repeated after 30 min at half the initial doses.

 

Side Effects

Osmotic disturbances. Oral: catharsis (at high doses).

Introduction

Sodium thiosulfate acts as an antidote in the treatment of cyanide poisoning. It acts as a sulphur-donating substrate for the enzyme rhodanese, thus speeding up the conversion of cyanide to thiocyanide, which is relatively non toxic. It is often used in combination with sodium nitrite but may be used alone in less severe poisoning.

AmiClean Precaution

May irritate eyes, skin and respiratory tract.

Interaction

Decreases toxicity of cisplatin through rapid chemical inactivation of its platinum component.

Pregnancy Lactation use

Pregnancy Category- C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Contraindication

Oedematous sodium-retaining conditions.

Special Warning

 

Acute Overdose

 

Interaction with other Medicine

 

Storage Condition

 

AmiClean Tablet price in Bangladesh 0.84