Ametrol Vaginal Tablet

Brand Name: Ametrol
Generic: Metronidazole + Miconazole Nitrate
Weight: 100 mg+100 mg
Type: Vaginal Tablet
Therapeutic Class: Drugs used in Vaginal and Vulval condition
Manufacturer: Ambee Pharmaceuticals Ltd.
Price: 15.46
Last Updated: 2020-11-22 18:15:00

Ametrol Vaginal Tablet Uses

Ametrol Vaginal Tablet contains Metronidazole + Miconazole Nitrate. Ametrol uses:

Vaginal treatment of female urogenital trichomonas infection, prevention & local therapy of candidiasis.

Ametrol Vaginal Tablet Doses

Ametrol Vaginal Tablet contains Metronidazole + Miconazole Nitrate 100 mg+100 mg. Ametrol doses:

In trichomoniasis, concurrently with oral metronidazole treatment and 1 vaginal tablet should be inserted high up into the vagina once a day (preferably before going to bed at night) for 10 days. Long-term recovery may be expected only is response to the simultaneous oral treatment of both partners. 

In candidiasis or other fungal infections, 1 vaginal tablet has to be inserted high up into the vagina for 10 days. The vaginal tablet should be slightly moistened before application.

 

Side Effects

Nausea, vomiting, febrile reactions, rash, drowsiness, diarrhoea, anorexia and flushing, hepatitis. Local irritation and sensitisation, contact dermatitis.

Introduction

Metronidazole is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms. It is active against most anaerobic protozoa, some gm+ve, gm-ve and facultative anaerobes.

Miconazole inhibits ergosterol synthesis thus damaging fungal cell wall membrane and increases its permeability, allowing leakage of nutrients.

Ametrol Precaution

For external use only; discontinue if sensitization or irritation occurs. Pregnancy and lactation

Interaction

Metronidazole: Disulfiram-like reaction with alcohol. Increased oral anticoagulant effect, blood levels of phenytoin, lithium toxicity, plasma cone of astemizole & terfenadine; blood cone of carbamazepine. Decreased blood levels with phenobarb. Risk of CNS-related effects (eg psychotic reactions) with disulfiram. Increased blood levels & neurologic effects with cimetidine. May increase blood levels & toxicity of fluorouracil; toxicity of cyclosporine. Increased cardiotoxicity with amiodarone. Interference with blood levels of liver enzymes, glucose (hexokinase method), theophylline & procainamide. Decreased levels with phenytoin.

Miconazole: Increased risk of bleeding with acenocoumarol, anisindione, dicumarol, phenindione, phenprocoumon, warfarin; plasma cone & exposure to oxybutinin.

May increase risk of phenytoin, phosphenytoin, cyclosporine, trimetrexate toxicity & cardiotoxicity with pimozide. May inhibit metabolism of astemizole, cisapride & terfenadine. Reduced carbamazepine metabolism. Increased or prolonged effects of opioid (fentanyl). May cause hypoglycemia with glimepiride. Reduced clearance & increased plasma cone of oxycodone. May increase bioavailability of tolterodine (in patients with deficient CYP2D6 activity).

Pregnancy Lactation use

Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Contraindication

Hypersensitivity; hepatic impairment (oral gel). Porphyria.

Special Warning

 

Acute Overdose

 

Interaction with other Medicine

 

Storage Condition

 

Ametrol Vaginal Tablet price in Bangladesh 15.46

Related Drugs

None found