Ametil Tablet

Brand Name:	Ametil
Generic:	Prochlorperazine
Weight:	5 mg
Type:	Tablet
Therapeutic Class:	Anti vertigo drugs, Anti-emetic drugs
Manufacturer:	Aristopharma Ltd.
Price:	0.64
Last Updated:	2020-11-20 18:15:00

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Ametil Tablet Uses

Ametil Tablet contains Prochlorperazine. Ametil uses:

Ametil Tablet Maleate Tablet: Each tablet contains Ametil Tablet maleate 5 mg.

Ametil Tablet Mesilate Syrup: Each 5 ml syrup contains Ametil Tablet maleate 5 mg

Ametil Tablet Mesilate Injection: Each 1 ml ampoule contains Ametil Tablet mesilate 12.5 mg.

For control of severe nausea and vomiting caused by radiation therapy, cancer chemotherapy, surgery, and other conditions.
Relieving nausea, vomiting and attacks of dizziness or spinning sensations (vertigo) associated with Meniere's disease and other inner ear disorders.
For the treatment of psychotic illness such as schizophrenia (hallucinations and hostility).
Acute mania.
For the short-term treatment of generalized non-psychotic anxiety.

Ametil Tablet Doses

Ametil Tablet contains Prochlorperazine 5 mg. Ametil doses:

Antiemetic:

Children (not recommended in children <10 kg or <2 years):

10-14 kg: 2.5 mg every 12-24 hours as needed; maximum: 7.5 mg/day
15-18 kg: 2.5 mg every 8-12 hours as needed; maximum: 10 mg/day
19-39 kg: 2.5 mg every 8 hours or 5 mg every 12 hours as needed; maximum: 15 mg/day

Adults: 5-10 mg 3-4 times/day; usual maximum:40 mg/day

Antipsychotic:

Children 2-12 years (not recommended in children <10 kg or <2 years): 2.5 mg 2-3 times/day; increase dosage as needed to maximum daily dose of 20 mg for 2-5 years and 25 mg for 6-12 years
Adults: 5-10 mg 3-4 times/day; doses up to 150 mg/day may be required in some patients for treatment of severe disturbances

Nonpsychotic anxiety:

Adults: Usual dose: 15-20 mg/day in divided doses; do not give doses >20 mg/day or for longer than 12 weeks
Elderly: Initial: 2.5-5 mg 1 -2 times/day; increase dose at 4 to 7 day intervals by 2.5-5 mg/day; increase dosing intervals (twice daily, thrice daily, etc) as necessary to control response or side effects; maximum daily dose should probably not exceed 75 mg in elderly; gradual increases (titration) may prevent some side effects or decrease their severity. Ametil Tablet may be administered without regards of meal.

Side Effects

Drowsiness, jaw, neck, and back muscle spasms, fine worm-like tongue movements, rhythmic face, mouth, or jaw movements, slow or difficult speech, difficulty swallowing, restlessness and pacing, tremors, shuffling walk, skin rash, yellowing of the skin or eyes.

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Introduction

Ametil Tablet is a potent phenothiazine antipsychotic, derivative of the piperazine group, now largely used as an antiemetic and to treat vertigo. The effects of this drug is apparent at all levels of the nervous system. It antagonizes postsynaptic dopamine D1 receptor that activates adenylate cyclase and synthesis of cAMP. It also antagonizes D2 receptors which do not activate adenylate cyclase. It also inhinits pre- and post synaptic adrenoreceptors and also acetylcholine, serotonin and histamine receptors. These various pharacodynamic actions combine to produce not only antipsychotic, but also central antiemetic and sedative effects.

Ametil Precaution

Caution should be taken while performing tasks that require alertness, such as driving or using machinery. Use of alcohol can cause extreme drowsiness. This medication may increase sensitivity to sunlight. Prolonged sun exposure should be avoided and a sunscreen and protective clothing should be taken when anybody is exposed to the sun. This medication can reduce sweating making more susceptible to heat stroke.

Interaction

Alcohol, barbiturate & other sedatives may increase the CNS depressant action. Some drugs like Antacids, antiparkinson's drug, lithium may interfere the absorption of Ametil Tablet. This drug may interfere the plasma concentration of Propanolol, Phenobarbital.

Pregnancy Lactation use

No evidence of adverse effects of this drug has been reported during pregnancy & lactation.

Contraindication

Hypersensitivity to prochlorperazine or any component of the formulation, severe CNS depression; coma; should not be used in children <2 years of age or <10 kg.