|Therapeutic Class:||Short-acting selective β2-adrenoceptor stimulants|
|Manufacturer:||APC Pharma Ltd.|
|Last Updated:||2020-11-21 18:15:00|
Ambuterol Tablet contains Bambuterol Hydrochloride. Ambuterol uses:
Bambuterol is indicated for Bronchial asthma, chronic bronchitis, emphysema & other lung diseases where bronchospasm is a complicating factor.
Ambuterol Tablet contains Bambuterol Hydrochloride 10 mg. Ambuterol doses:
Adult or Elderly: The recommended initial dose 10 mg. The dose may be increased to 20 mg after 1-2 weeks depending on the clinical effect.
Children 2-5 years: The recommended normal dose 10 mg (10 ml syrup).
Children 6-12 years: The recommended normal dose 10 mg (10 ml syrup). The dose may be increased to 20 mg.
Common side effects are fatigue, nausea, palpitation, headache, dizziness & tremor.
Bambuterol is an adrenergic β2 receptor agonist which predominantly stimulates β2 receptor, thus producing relaxation of bronchial smooth muscle, inhibition of release of endogenous spasmogens, inhibition of edema caused by endogenous mediators & increased mucocilliary clearance.
Reduce the dose in renal impairment, avoid in cirrhosis and severe hepatic impairment. Caution should be observed in patients with severe cardiovascular disorder, such as ischaemic heart disease, tachyarrhythmias or severe heart failure.
Succinylcholin, MAOIs (monoamine oxidase inhibitors), β2-blockers, corticosteroids, diuretics, muscle relaxants, sympathomimetic xanthine derivatives. Bambuterol may partly or totally inhibit the effect of β-blockers.
Pregnant women: There is no definite evidence of ill consequence during pregnancy. Nevertheless, the drug should not be used during the first trimester of pregnancy, unless the expected benefit is thought to outweigh any possible risk to the fetus.
Lactating mother: It is excreted in breast milk. So, patients taking this drug should not breast-feed.
Bambuterol is contraindicated in hepatic impairment, liver cirrhosis or severely impaired liver function.
Impaired renal function (GFR 50 ml/min): The recommended starting dose is 5 mg, which may be increased to 10 mg after one to two weeks, depending on the clinical effect.
Impaired hepatic function: Not recommended because of unpredictable conversion to terbutaline.
Keep away from light, store in a cool and dry place. Keep out of reach of children.
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