Ambrisan 10
Ambrisan 10 Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Ambrisan 10 is a brand name. Its generic name is Ambrisentan.
Ambisentan Introduction
Ambisentan, also known as Letairis®, is a medication used to treat pulmonary arterial hypertension (PAH). It is an endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension in adult patients to improve exercise ability and delay clinical worsening.
Uses For Ambisentan
Ambisentan is used to treat pulmonary arterial hypertension (PAH) in adult patients to improve exercise ability and delay clinical worsening. PAH is a type of high blood pressure in the vessels that supply the lungs, causing an increased workload on the heart and eventually leading to right-sided heart failure.
Mechanism of Action
Ambisentan is an endothelin receptor antagonist, which means it works by blocking the action of the vasoconstrictor peptide endothelin-1. This protein plays a role in increasing blood pressure in the lungs and in the progression of pulmonary arterial hypertension (PAH). By blocking endothelin's action, the drug helps reduce pulmonary artery pressure, increase exercise capacity, and slow the progression of the disease.
How Long Does It Take To Work?
Ambisentan is usually taken once daily. It usually takes a few weeks to a few months for the drug to begin working and for the desired effects to be seen. It is important to follow your doctor's directions and take the medication as prescribed.
Absorption
Ambisentan is rapidly and extensively absorbed after oral administration. Peak plasma concentration is reached 1.5 to 2.5 hours after dosing and has an absolute bioavailability of approximately 75%.
Route of Elimination
Ambisentan is mainly eliminated in the feces (85%) via biliary excretion. About 15% of the dose is eliminated unchanged in the urine.
Dosage
The recommended starting dose of Ambisentan is 5 mg orally once daily. Depending on the response of the patient, the dose can be increased to 10 mg once-daily by 2 weeks and to a maximum of up to 20 mg once daily. The drug should be taken with food, with the last dosage taken at least 7 hours before going to bed. The most common side effects of this medication are headache, back pain, cough, nausea, and dizziness. For people with liver problems, the dosage should be reduced.
Administration
Ambisentan should be taken exactly as prescribed by your doctor. It is usually taken orally once daily, with or without food and can be taken with or without other medicines, such as diuretics. It is important not to miss a dose or take two doses at once. If you miss a dose, take it as soon as you remember, unless it is close to the next dose. Do not take two doses at once.
Side Effects
The most common side effects of Ambisentan include headache, back pain, cough, nausea, and dizziness. Other possible side effects include swelling in the hands or feet, difficulty breathing, chest pain, rash, and depression. If you experience any serious or persistent side effects, contact your doctor immediately.
Toxicity
It is not known whether Ambisentan is toxic when taken in excess. If you think you have taken too much medicine, contact your doctor or poison control center right away.
Precautions
Ambisentan may cause swelling in the hands or feet. If you experience this, contact your doctor immediately. The drug can also cause a decrease in blood sodium levels, so you should monitor your electrolyte levels while taking Ambisentan. The drug should not be taken during pregnancy. Women of childbearing potential should use effective contraception while taking the medication.
Interaction
Ambisentan can interact with other medications, such as angiotensin-converting enzyme (ACE) inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), potassium-sparing diuretics, and warfarin. Tell your doctor about all medications you are taking before starting Ambisentan.
Disease Interaction
Patients with liver or kidney impairment should use Ambisentan with caution as the drug is mainly eliminated through the kidneys and liver. Additionally, Ambisentan can lower blood pressure and should be used with caution in patients with hypotension or conditions that can cause hypotension, such as dehydration.
Drug Interaction
Ambisentan can interact with drugs such as angiotensin-converting enzyme (ACE) inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), potassium-sparing diuretics, and warfarin. Tell your doctor about all medications you are taking before starting Ambisentan.
Food Interactions
Ambisentan can interact with certain foods, such as grapefruit juice, and should not be taken with these items. Additionally, Ambisentan should not be taken with alcohol or other drugs that can increase the risk of side effects.
Pregnancy Use
Ambisentan is not recommended for use during pregnancy. Women of childbearing potential should use effective contraception while taking the medication.
Lactation Use
It is not known whether Ambisentan is excreted in breast milk. Therefore, the drug should be used with caution in breastfeeding women.
Acute Overdose
In the event of an acute overdose, contact a poison control center or emergency room immediately. Symptoms of an overdose could include dizziness, confusion, nausea, vomiting, and fatigue.
Contraindication
Ambisentan is contraindicated in patients with severe liver impairment or active liver disease due to the risk of further liver damage. Additionally, Ambisentan should not be used in pregnant women, as it may be harmful to the fetus.
Use Directions
Take Ambisentan exactly as prescribed by your doctor. Take with or without food, and take the last dosage at least 7 hours before going to bed. Do not miss doses or take two doses at once. If you miss a dose, take it as soon as you remember, unless it is close to the next dose.
Storage Conditions
Ambisentan should be stored in a dry and cool place, away from direct light. Keep out of reach of children and pets.
Volume of Distribution
The volume of distribution of Ambisentan is approximately 4800 L.
Half Life
The plasma half-life of Ambisentan is approximately 4 to 5 hours.
Clearance
The clearance of Ambisentan is approximately 600 L/h.
Here you find in details version of Ambrisan 10