|Therapeutic Class:||Penicillinase-resistant penicillins|
|Manufacturer:||Ambee Pharmaceuticals Ltd.|
|Last Updated:||2020-11-21 18:15:00|
Ambeeclox Capsule contains Cloxacillin. Ambeeclox uses:
Cloxacillin is indicated for the treatment of infections caused by Grampositive organisms including infections caused by β-lactamase producing Staphylococci such as :
Ambeeclox Capsule contains Cloxacillin 500 mg. Ambeeclox doses:
Upper Respiratory Tract Infection (Adult):
Upper Respiratory Tract Infection (Pediatric):
Skin and Structure Infection (Adult):
Skin and Structure Infection (Pediatric):
Common side effects are skin rash, transient diarrhoea, nausea, heartburn, pruritus and disturbance of blood electrolyte. Rarely anaphylactic shock.
Cloxacillin inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
Cloxacillin should be given with caution to patients with known history of allergy.
May diminish the effect of BCG and typhoid vaccine. May increase risk of methotrexate toxicity. May diminish the therapeutic effect of Na picosulfate. May decrease serum concentrations of mycophenolate. May prolong bleeding time with anticoagulants. Increased serum concentrations with probenecid. Tetracycline may antagonise the bactericidal effect of cloxacillin.
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Cloxacillin should not be given to patients known to be hypersensitive to penicillin.
Dry powder: Store below 25° C. Reconstituted solution: Store between 2-8° C (stable for 4 days); 23° C (stable for 24 hr).
Ambeeclox Capsule price in Bangladesh 8.34