|Manufacturer:||Grifols Biologicals Inc, USA|
|Last Updated:||2020-11-22 18:15:00|
Alphanate IV Infusion contains Alphanate. Alphanate uses:
Alphanate, (antihemophilic factor/von Willebrand factor complex), is indicated for:
Alphanate IV Infusion contains Alphanate 250 IU/vial. Alphanate doses:
Alphanate contains the labeled amount of Factor VIII expressed in International Units (IU) FVIII/vial and Willebrand.
Factor: Ristocetin Cofactor activity in IU VWF:RCo/vial.
Hemophilia A: Control and prevention of bleeding episodes
Von Willebrand Disease: Surgical and/or invasive procedure in adult and pediatric patients except Type 3 undergoing major surgery
Geriatric Use: No human or animal data. Use only if clearly needed.
Alphanate is for intravenous use only after reconstitution. Use plastic disposable syringes. Do not refrigerate after reconstitution. Reconstituted Alphanate may be stored at room temperature (not to exceed 30° C) prior to administration, but administer intravenously within three hours.
Discard any unused contents into the appropriate safety container. Do not administer Alphanate at a rate exceeding 10 mL/minute.
The most frequent adverse events reported with Alphanate in >5% of patients are respiratory distress, pruritus, rash, urticaria, face edema, paresthesia, pain, fever, chills, joint pain and fatigue
Antihemophilic Factor/ Von Willebrand Factor Complex (Human) contains Antihemophilic Factor (FVIII) and von Willebrand Factor (VWF), constituents of normal plasma, which are required for clotting. The administration of Alphanate temporarily increases the plasma level of FVIII, thus minimizing the hazard of hemorrhage in patients with hemophilia A. FVIII is an essential cofactor in activation of factor X leading to formation of thrombin and fibrin. VWF promotes platelet aggregation and platelet adhesion on damaged vascular endothelium; it also serves as a stabilizing carrier protein for the procoagulant protein FVIII.
Risk of thromboembolic events & infections. Pregnancy.
Pregnancy: No human or animal data. Use only if clearly needed
Labor and Delivery: No human or animal data. Use only if clearly needed
Nursing Mothers: No human or animal data. Use only if clearly needed
Alphanate is contraindicated in patients who have manifested life-threatening immediate hypersensitivity reactions, including anaphylaxis, to the product or its components.
Pediatric Use: Clinical trials for safety and effectiveness in pediatric hemophilia A patients have not been conducted. The hemostatic efficacy of Alphanate has been studied in 20 pediatric subjects with VWD 18 years of age and under. Based on the data from a subset of these subjects, age had no effect on the pharmacokinetics of VWF:RCo
Geriatric Use: No human or animal data. Use only if clearly needed
Alphanate IV Infusion price in Bangladesh 12.60