Allygest

Allygest Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Allygest is a brand name. Its generic name is Allylestrenol.

Introduction

Allygest (INN) is a synthetic steroidal progestin with antigonadotropic and antiglucocorticoid activity used as a treatment for recurrent miscarriage and threatened miscarriage.

Uses for

Allygest is indicated for the prevention and treatment of recurrent and threatened miscarriages, and for the prevention of preterm labor.

Mechanism of Action

Allygest is believed to act mainly through its estrogenic component. It promotes the development of the endometrium, enhancing the likelihood of successful implantation of a fertilized ovum. It also improves the strength of uterine contractions and exerts a sedative effect on the uterus and relaxes its smooth muscles.

How Long Does It Take to Work?

Allygest begins to work immediately on administration, although its effects may not be fully manifest in the body until some weeks later. For example, if it is being used to reduce the risk of preterm labor, its effects may be seen within the week following administration.

Absorption

Allygest is rapidly and completely absorbed from the gastrointestinal tract following oral administration.

Route of Elimination

Allygest is metabolized primarily in the liver and excreted in the bile as metabolites. Approximately 40% of a dose of allylestrenol is excreted in the urine and 10% in the feces.

Dosage

The recommended starting dose of allylestrenol is 10 mg three times daily for three to six days. The dose may be increased up to 20 mg three times daily depending on the patient's response to treatment.

Administration

Allygest is taken orally, usually with a full glass of water, after meals or at bedtime.

Side Effect

The most frequently reported side effects of allylestrenol include nausea, dizziness, bloating, and breast tenderness.

Toxicity

No cases of toxicity from allylestrenol have been reported.

Precautions

Allygest should be used with caution in patients who have a history of liver or kidney disease, diabetes, or any other endocrine disorder. Women taking allylestrenol should not breastfeed while using the drug.

Interactions

Allygest may interact with certain medications and reduce their effectiveness. Patients taking hormone replacement therapy, oral contraceptives, or anticoagulants should not take allylestrenol.

Disease Interactions

Allygest should not be used in patients with a history of any of the following conditions: stroke, breast cancer, endometrial hyperplasia, or a history of jaundice or liver disease.

Drug Interactions

Allygest may interact with certain medications and reduce their effectiveness. Patients taking hormone replacement therapy, oral contraceptives, or anticoagulants should not take allylestrenol. This drug should also not be used in combination with barbiturates, phenytoin, cyclosporine, or any other drug metabolized by CYP3A4 enzyme.

Food Interactions

It is not known if allylestrenol interacts with food. Patients should discuss diet and potential food interactions with their doctor prior to beginning treatment.

Pregnancy Use

Allygest should not be used during pregnancy as it may cause harm to the fetus.

Lactation Use

It is not known if allylestrenol is excreted in breast milk. This drug should not be used while breastfeeding.

Acute Overdose

No cases of acute overdose of allylestrenol have been reported. However, if an overdose is suspected, contact a healthcare provider immediately.

Contraindication

Allygest should not be used in patients with any of the following conditions: porphyria, thromboembolism, undiagnosed vaginal bleeding, or a history of breast or endometrial cancer.

Use Direction

Allygest should be taken orally, usually with a full glass of water, after meals or at bedtime. The recommended starting dose is 10 mg three times daily for three to six days. The dose may be increased up to 20 mg three times daily depending on the patient's response to treatment.

Storage Condition

Allygest should be stored at room temperature in a tight, light-resistant container. It should not be stored in the bathroom or near any heat source.

Volume of Distribution

The volume of distribution of allylestrenol is approximately 18 – 22 L/kg.

Half Life

The half-life of allylestrenol is estimated to range from 3.4 – 7.5 hours.

Clearance

The average clearance of allylestrenol is approximately 5.1 mL/min/kg.

Here you find in details version of Allygest

Some Frequently Asked Questions About Allygest

What is Allygest?

Allygest is a synthetic progestogen, or a man-made hormone, used in the treatment of threatened abortion and habitual abortion.

What is Allygest used for?

Allygest is used to prevent threatened miscarriage and habitual abortion in pregnant women. It is also used in combination with estrogen to treat secondary amenorrhea.

What is the dosage of Allygest?

The usual dose of Allygest is 5 mg to 10 mg a day. Dosage adjustments may be required depending on the individual patient’s condition.

What are the side effects of Allygest?

The most common side effects of Allygest include nausea, vomiting, abdominal pain, headaches, drowsiness, and diarrhea. Other serious side effects may include depression, skin rash, and facial swelling. If any of these side effects occur, seek medical attention right away.

Can Allygest be used in combination with other medications?

Allygest may interact with certain medications, so it should not be used in combination with other medications without consulting a doctor. Always make sure to tell your doctor about all medications that you are taking.

What precautions should be taken while consuming Allygest?

Never take more than the prescribed dose of Allygest. Also, if you are pregnant or planning to become pregnant, consult your doctor before using Allygest. Be sure to tell your doctor if you are breastfeeding.

What are the contraindications for Allygest?

Allygest should not be used in people who are hypersensitive to this drug or any of its components. It should also not be used in people with a history of stroke or thromboembolic disease.

Is Allygest available in generic form?

Yes, Allygest is available in generic form.

What is the price of Allygest?

The price of Allygest varies depending on the pharmacy and where it is purchased. It is typically less expensive in generic form.

Is Allygest available over the counter?

No, Allygest is a prescription medication and is not available over the counter.

What is the mechanism of action of Allygest?

Allygest works by stopping the release of certain hormones that are responsible for triggering miscarriage and habitual abortion. It also helps to reduce the risk of premature delivery.

How long does it take for Allygest to work?

The effects of Allygest typically begin to be felt within one to two weeks of starting treatment. It is important to continue taking Allygest as prescribed in order for it to be effective.

Can Allygest be taken during pregnancy?

Yes, Allygest can be used in pregnant women in order to prevent miscarriage and habitual abortion. However, it should not be used in the last three months of pregnancy without consulting a doctor.

Are there any known drug interactions with Allygest?

Yes, Allygest may interact with certain drugs, so it is important to tell your doctor about any medications or supplements you are taking before taking Allygest.

Can Allygest be taken with anticoagulant drugs?

No, Allygest should not be taken with anticoagulant drugs without consulting a doctor first.

Can Allygest be used in patients with liver or kidney diseases?

Yes, Allygest may be used in patients with liver or kidney diseases, but the dose may need to be adjusted for these patients. Consult a doctor for more information.

Are there any foods that should be avoided with Allygest?

There are no foods that should be avoided while taking Allygest, however it is important to follow a healthy, balanced diet to ensure optimal health.

Can Allygest cause weight gain?

Weight gain is not a common side effect of Allygest, although some patients may experience an increase or decrease in appetite.

Does Allygest affect fertility?

Allygest has not been shown to affect fertility. However, it is important to consult a doctor if you are planning to become pregnant while taking Allygest.

Can Allygest cause sleep disturbances?

Yes, Allygest can cause sleep disturbances, such as insomnia or vivid dreams. If this occurs, then consulting a doctor is recommended.

Can Allygest cause mood changes?

Yes, Allygest can cause mood changes, such as increased anxiety or depression. If this occurs, then consult a doctor.

Can Allygest affect menstrual cycles?

Yes, Allygest can affect menstrual cycles. This is because it prevents the body from releasing hormones that are responsible for triggering ovulation. It can also lead to irregular bleeding.

Can Allygest cause headaches?

Yes, Allygest can cause headaches in some patients. If you experience a persistent or severe headache while taking Allygest, then consult a doctor.

Can Allygest lower blood pressure?

Yes, Allygest can lower blood pressure in some patients. It is important to monitor your blood pressure regularly while taking Allygest.

Can Allygest be used to treat breast cancer?

No, Allygest should not be used to treat breast cancer. It is important to consult a doctor before taking any medication for breast cancer.

Is Allygest linked to an increased risk of cancer?

No, Allygest is not linked to an increased risk of cancer. However, it is important to consult a doctor if you are concerned about the potential risk of cancer while taking Allygest.

Does Allygest affect the liver?

Yes, Allygest can affect the liver in some patients. It is important to monitor your liver functions regularly while taking Allygest.

Can Allygest be used in women of childbearing age?

Yes, Allygest can be used in women of childbearing age, but it should not be used for the treatment of pregnancy unless specifically prescribed by a doctor.

Can Allygest cause skin rashes?

Yes, Allygest can cause skin rashes in some patients. If you experience any skin rashes while taking Allygest, then consult a doctor for treatment.

Can Allygest affect libido?

Yes, Allygest can have an effect on libido in some patients. Consult a doctor if you are experiencing any changes in your libido while taking Allygest.

Does Allygest affect the heart?

Yes, Allygest can affect the heart in some people. It is important to inform your doctor if you have any heart-related conditions before taking Allygest.

Does Allygest accumulate in the body?

No, Allygest is not known to accumulate in the body. This means that it is not necessary to adjust the dosage of Allygest based on the amount of time it has been taken.

Is Allygest an anti-inflammatory drug?

No, Allygest is not an anti-inflammatory drug. It is a synthetic progestogen used for the prevention of miscarriage and habitual abortion.

Can Allygest be used to induce labor?

No, Allygest should not be used to induce labor unless specifically prescribed by a doctor.

Can Allygest cause drowsiness?

Yes, Allygest can cause drowsiness in some patients. It is important to be aware of how Allygest affects you before operating any machinery or driving a vehicle.

Does Allygest cause hair loss?

No, Allygest does not cause hair loss. However, it is important to consult a doctor if you experience any unusual hair loss while taking Allygest.

Can Allygest cause breast tenderness?

Yes, Allygest can cause breast tenderness in some patients. If this occurs, then consult a doctor.

Can Allygest be taken while breastfeeding?

Yes, Allygest can be taken while breastfeeding, but it is important to inform your doctor if you are breastfeeding while taking Allygest.

Can Allygest cause visual disturbances?

Yes, Allygest can cause visual disturbances, such as blurred vision or double vision. If this occurs, then consult a doctor.

Does Allygest cause nausea?

Yes, Allygest can cause nausea in some patients. If you experience persistent or severe nausea while taking Allygest, then consult a doctor.