Alen D Tablet

Brand Name: Alen D
Generic: Alendronic Acid + Vitamin D3
Weight: 70 mg+2800 IU
Type: Tablet
Therapeutic Class: Combined preparations: Inhibiting bone resorption
Manufacturer: ACI Limited.
Price: 35.24
Last Updated: 2020-11-20 18:15:00

Alen D Tablet Uses

Alen D Tablet contains Alendronic Acid + Vitamin D3. Alen D uses:

Alendronic Acid & Vitamin D3 is indicated in:

  • is indicated for the treatment of osteoporosis in postmenopausal women and to increase bonemass in men with osteoporosis. Alendronic Acid & Vitamin D3 alone should not be used to treat vitamin D deficiency.

Alen D Tablet Doses

Alen D Tablet contains Alendronic Acid + Vitamin D3 70 mg+2800 IU. Alen D doses:

Treatment of osteoporosis in postmenopausal women: One tablet once weekly.Treatment to increase bonemass in men with osteoporosis: One tablet once weekly.Dosing in elderly and renal insufficiency: No dosage adjustment is necessary for the elderly or for patients with mild-to-moderate renal insufficiency (creatinine clearance 35 to 60 mL/min). Bonemass D is not recommended for patients with more severe renal insufficiency (creatinine clearance <35 mL/min) due to lack of experience.Bonemass D must be taken at least one to half hour before the first food, beverage, or medication of the day with plain water only. Other beverages (including mineral water), food, and some medications are likely to reduce the absorption of Alendronate. To facilitate delivery to the stomach and thus reduce the potential for esophageal irritation, Bonemass D should only be swallowed upon arising for the day with a full glass of water and patients should not lie down for at least 30 minutes and until after their first food of the day. Bonemass D should not be taken at bedtime.

To permit adequate absorption, Alendronate & Colecalciferol must be taken at least 30 minutes before the first food, beverage or medication of the day with plain water only. Other beverages (including mineral water), food and some medications are likely to reduce the absorption of Alendronate. To facilitate delivery to the stomach and thus to reduce the potential for esophageal irritation, Alendronate & Colecalciferol tablet should only be swallowed upon rising for the day with a full glass of water. Patients should not lie down for at least 30 minutes after taking Alendronate until after their first food of the day. Alendronate & Colecalciferol should not be taken at bed time.

Side Effects

The most common side-effect is digestive reactions from Bonemass D. These reactions include irritation, inflammation, or ulcers of the esophagus, which may sometimes bleed. This may occur especially if patients do not drink a full glass of water with Bonemass D or if they lie down in less than 30 minutes or before their first food of the day. Less common side-effects are nausea, vomiting, a full or bloated feeling in the stomach, constipation, diarrhea, black or bloody stools, gas, headache, a changed sense of taste, and bone, muscle, or joint pain.

Introduction

Alendronate Sodium is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. Colecalciferol (vitamin D3) is a secosterol that is the natural precursor of the Calcium-regulating hormone Calcitriol (1,25-dihydroxy vitamin D3).

Alen D Precaution

Alendronate Sodium: Hypocalcemia must be corrected before initiating therapy with Bonemass D. Other disorders affecting mineral metabolism (such as vitamin D deficiency) should also be effectively treated. In patients with these conditions, serum calcium and symptoms of hypocalcemia should be monitored during therapy with Bonemass D.

Colecalciferol: Bonemass D alone should not be used to treat vitamin D deficiency. Patients at increased risk for vitamin D insufficiency (e.g. those who are nursing home bound, chronically ill, over the age of 70 years) should receive vitamin D supplementation in addition to that provided in Bonemass D.

Interaction

Calcium supplement, antacids and some oral medications will interfere with absorption of Alendronate if taken at the same time. Intravenous ranitidine makes the bioavailability of oral Alendronate double. Incidence of upper gastro-intestinal adverse events associated with NSAID and aspirin appears to be greater with concomitant administration of Alendronate. Mineral oils, orlistat, and bile acid sequestrants (e.g., cholestyramine, colestipol) may impair the absorption of vitamin D. Anticonvulsants, cimetidine, and thiazides may increase the catabolism of vitamin D.

Pregnancy Lactation use

There is no studies in pregnant women.  should be used during pregnancy only if the potential benefit justifies the potential risk to the mother and fetus. Colecalciferol and some of its active metabolites pass into breast milk. It is not known whether Alendronate is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when it is administered to nursing women. This is not indicated for use in children.

Contraindication
  • Abnormalities of the esophagus which delay esophageal emptying, such as stricture or achalasia.
  • Inability to stand or sit upright for at least 30 minutes.
  • Hypersensitivity to any component of this product.
  • Hypocalcaemia.
Special Warning

Dosing in elderly and renal insufficiency: No dosage adjustment is necessary for the elderly or for patients with mild-to-moderate renal insufficiency (creatinine clearance 35 to 60 mL/min). Alendronic Acid + Vitamin D3 (Colecalciferol) is not recommended for patients with more severe renal insufficiency (creatinine clearance<35 mL/min) due to lack of experience.

Acute Overdose

Hypocalcemia, hypophosphatemia, and upper gastrointestinal adverse events, such as upset stomach, heartburn, esophagitis, gastritis, or ulcer, may result from oral overdosage.  Signs and symptoms of vitamin D toxicity include hypercalcemia, hypercalciuria, anorexia, nausea, vomiting, polyuria, polydipsia, weakness, and lethargy.

Alendronate Sodium: No specific information is available on the treatment of overdosage with Alendronate. Hypocalcemia, hypophosphatemia, and upper gastrointestinal adverse events, such as upset stomach, heartburn, esophagitis, gastritis, or ulcer, may result from oral overdosage. Milk or Antacids should be given to bind Alendronate. Due to the risk of esophageal irritation, vomiting should not be induced and the patient should remain fully upright.

Colecalciferol: There is limited information regarding overdosage of Colecalciferol associated with acute toxicity. Signs and symptoms of vitamin D toxicity include hypercalcemia, hypercalciuria, anorexia, nausea, vomiting, polyuria, polydipsia, weakness, and lethargy. Serum and urine calcium levels should be monitored in patients with suspected vitamin D toxicity. Standard therapy includes restriction of dietary calcium, hydration, and systemic glucocorticoids in patients with severe hypercalcemia.

Interaction with other Medicine

 

Storage Condition

Store in a cool and dry place. Protect from light & moisture. Keep out of the reach of children.

Alen D Tablet price in Bangladesh 35.24