Aldorin
Aldorin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Aldorin is a brand name. Its generic name is Epalrestat.
Introduction
Aldorin is an oral antidiabetic drug used alone or in combination with diet and exercise to improve blood glucose control in people with type 2 diabetes. It is usually used when diet, exercise, and/or other medications have not been effective.Uses
Aldorin is used to lower blood sugar levels in adults with type 2 diabetes. It works by decreasing the amount of glucose produced by the liver and increasing the sensitivity of muscle cells to insulin, which allows more glucose to be absorbed into muscles.Mechanism of Action
Aldorin works by inhibiting the enzyme aldose reductase, which is responsible for the conversion of glucose to sorbitol. This helps to reduce the amount of glucose in the blood by decreasing the amount of sugar that is produced by the body. Additionally, it works by increasing the sensitivity of the cells to insulin, allowing more glucose to be taken up into these muscles.How long does it take to work?
Aldorin generally begins to work within 2-3 weeks of starting treatment. However, the full effects may not be seen until after 3-4 months.Absorption
Aldorin is well absorbed from the gastrointestinal tract and its peak serum concentrations are achieved approximately 1 hour after oral administration.Route of Elimination
Aldorin is eliminated mainly through the kidneys, with a small percentage excreted in the feces.Dosage
The recommended dosage of Aldorin is 5-30mg orally twice a day, with or without food. It is important to take the medication exactly as prescribed. If you miss a dose, take it as soon as you remember (up to 12 hours later) and then continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.Administration
Aldorin should be taken with a full glass of water and can be taken with or without food. It should not be crushed, cut or chewed before swallowing, as this may destroy or alter its effects.Side Effects
Common side effects of Aldorin includes upper respiratory infection, headache, nausea, dizziness, and gastrointestinal symptoms including gas, bloating, and constipation.Toxicity
There have been no reports of significant adverse effects and/or toxicity associated with Aldorin administration.Precautions
Aldorin should not be used in patients with a history of allergy or hypersensitivity to it or any of its components. It should also not be used by pregnant women, nursing mothers, or children less than 18 years of age.Interactions
Aldorin may interact with other medicines or supplements, including insulin, oral contraceptives, anti-fungals, anti-HIV medication, phenytoin, and warfarin. Therefore, it is important to tell your doctor about any medications you are taking, including over-the-counter drugs, vitamins, or herbal supplements.Drug Interactions
Aldorin may interact with other drugs or medications, including phenytoin, warfarin, certain updated blood pressure medications, HIV medicine, and antibiotics. As a result, these medications may increase or decrease the effects of Aldorin.Food Interactions
Aldorin should be taken with a full glass of water and can be taken with or without food. It is important to take the medication exactly as prescribed.Pregnancy Use
Aldorin should not be used by pregnant women. If you become pregnant while taking Aldorin, you should discontinue use and contact your doctor immediately.Lactation Use
Aldorin should not be used by nursing mothers due to the potential for it to pass into breast milk and cause adverse reactions in nursing infants.Acute Overdose
An acute overdose of Aldorin is not likely to be serious. Symptoms of an overdose may include nausea, vomiting, abdominal pain, and diarrhea. If an overdose is suspected seek medical help immediately.Contraindication
Aldorin is contraindicated in patients who are hypersensitive to it or any of its components.Use Directions
Aldorin should be taken with a full glass of water and can be taken with or without food. It should not be crushed, cut or chewed before swallowing, as this may destroy or alter its effects. It is important to take the medication exactly as prescribed.Storage Condition
Aldorin should be stored at room temperature and kept away from light and moisture. It should also be kept out of reach of children.Volume of Distribution
The volume of distribution for Aldorin is about 36 L.Half Life
The half-life of Aldorin is 19-22 hours.Clearance
The clearance rate of Aldorin is 14-16 mL/min.Here you find in details version of Aldorin
Some Frequently Asked Questions About Aldorin
https://www.medicinesfaq.com/brand/aldorin,
https://www.chemspider.com/Chemical-Structure.1266086.html,
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049730,
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=31539,
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL56337,
https://zinc.docking.org/substances/ZINC000001533688,
https://en.wikipedia.org/wiki/Epalrestat,