Aggreno

Aggreno Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Aggreno is a brand name. Its generic name is Acetylsalicylic acid + Dipyridamole.

Introduction

Acetylsalicylic acid (ASA) and dipyridamole (DP) are two medications commonly combined to form a medicine called Aggrenox. In the United States, it is available as an extended-release capsule, taken twice daily. It is used for the prevention of strokes.

Uses for

Aggrenox is used to reduce the risk of having a stroke in people who have had a “transient ischemic attack” (TIA) or “mini-stroke” or have had a recent stroke due to a blood clot. ASA (Aspirin) is an antiplatelet drug which helps prevent platelets from sticking together and forming clots in the blood vessels, thus reducing the risk of stroke. Dipyridamole is also an antiplatelet drug, which works by keeping blood clots from forming.

Mechanism of Action

Aggrenox works by blocking the action of substances in the body that cause platelets to stick together and form clots in the blood vessels. Acetylsalicylic acid (ASA) prevents platelets from sticking together, thereby reducing the risk of stroke. Dipyridamole prevents the breakdown of platelets by blocking the action of an enzyme called phosphodiesterase. This decreases the risk of clot formation in blood vessels.

How Long Does it Take to Work?

The effects of Aggrenox are usually seen within 7-14 days of starting the medication.

Absorption

Aggrenox is absorbed from the gut and enters the bloodstream. Acetylsalicylic acid is rapidly absorbed from the gut, while the dipyridamole is absorbed more slowly.

Route of Elimination

Aggrenox is eliminated primarily through the kidneys. The acetylsalicylic acid is excreted by the kidneys while the dipyridamole is excreted mostly through the bile.

Dosage

The usual dosage of Aggrenox is 1 capsule (containing 200 mg of ASA and 25 mg of DP) twice daily. The dosage should be individualized according to the needs of the patient.

Administration

Aggrenox is to be taken with a full glass of water, and on an empty stomach. It should not be taken with other medications.

Side Effects

The most common side effects of Aggrenox include nausea, vomiting, diarrhea, stomach pain, headache, dizziness, and rash.

Toxicity

The toxic effects of Aggrenox include vomiting, difficulty breathing, fever, chest pain, and blood in the urine. If any of these symptoms occur, seek medical attention immediately.

Precautions

Aggrenox should be used with caution by those with a history of stomach ulcer or bleeding, blood clotting disorders, kidney or liver problems, or any other medical condition.

Interaction

Aggrenox may interact with other medications, such as antacids, warfarin, blood thinners, steroids, and nonsteroidal anti-inflammatory drugs (NSAIDs).

Disease Interaction

Aggrenox may increase the risk of bleeding in patients with certain diseases, such as ulcerative colitis, lupus erythematosus, or diabetes.

Drug Interaction

Aggrenox may interact with certain medications. These include anticoagulants such as warfarin, nonsteroidal anti-inflammatory drugs, oral contraceptives, steroids, and certain antibiotics.

Food Interactions

Certain food and drinks may interact with Aggrenox. They include foods or drinks containing caffeine (such as coffee and sodas) and non-steroidal anti-inflammatory drugs (NSAIDs).

Pregnancy Use

Aggrenox should not be used during pregnancy unless it is clearly needed. It should only be used if the benefit to the mother outweighs the potential risk to the unborn baby.

Lactation Use

Aggrenox should not be used during breastfeeding unless it is clearly needed.

Acute Overdose

Acute overdose of Aggrenox can result in nausea, vomiting, dizziness, headache, diarrhea, fainting, and blurred vision. Seek medical attention immediately if an overdose is suspected.

Contraindications

Aggrenox should not be used if you are allergic to either aspirin or dipyridamole, or have any risk of bleeding.

Use Direction

Aggrenox should be taken as prescribed by your healthcare provider. It should be taken with a full glass of water, and should not be taken with other medications.

Storage Condition

Aggrenox should be stored at room temperature and away from heat and moisture. Do not keep it in the refrigerator.

Volume of Distribution

The volume of distribution of Aggrenox is not known.

Half Life

The half-life of Aggrenox is not known.

Clearance

Aggrenox is cleared from the body by the kidneys.

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