Afrezza 4 Unit (30)- 8 Unit (60)

Afrezza 4 Unit (30)- 8 Unit (60), a brand name for a formulation containing essential Biphasic Insulin Aspart (rDNA), is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Afrezza 4 Unit (30)- 8 Unit (60), as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.

Introduction

Afrezza 4 Unit (30)- 8 Unit (60) is a type of insulin used to treat type 1 and type 2 diabetes. It helps the body use glucose more effectively, thereby reducing the risk of long-term diabetic complications.

Uses

Afrezza 4 Unit (30)- 8 Unit (60) is used to lower blood glucose levels in people with diabetes, both Type 1 and Type 2. It helps to lower abnormally high levels of glucose in the blood, known as hyperglycemia, and to reduce long-term risk of long-term complications associated with diabetes.

Mechanism of Action

Afrezza 4 Unit (30)- 8 Unit (60) works by stimulating the cells in the body to take up sugar from the bloodstream. This sugar is used by the cells as an energy source and can help keep blood sugar levels in a normal range. Biphasic insulin aspart also helps to reduce the amount of glucose released by the liver, further reducing the amount of sugar in the bloodstream.

How Long Does It Take to Work?

Biphasic insulin aspart usually takes around 30 minutes to take effect. The time it takes for the insulin to reach its maximum effect can vary from person to person, and it may take up to 2 hours for the full action of the insulin to be achieved.

Absorption

Biphasic insulin aspart is absorbed into the bloodstream after injection and reaches its maximum action within 2 hours. Its effect then gradually decreases over the course of the day, until it is no longer active.

Route of Elimination

Biphasic insulin aspart is eliminated from the bloodstream by the liver. It is metabolized into inactive metabolites, which are then eliminated through the kidneys and the gastrointestinal tract.

Dosage

The dosage of biphasic insulin aspart varies depending on individual needs and the severity of the condition. It is typically prescribed in the form of an injection, once or twice a day, depending on the individual's blood sugar levels and other factors. The injection site should be rotated each time to avoid irritation of the skin. The dose should be titrated as required.

Administration

Biphasic insulin aspart typically comes in the form of a pre-filled insulin pen or syringe. It should be injected subcutaneously (under the skin). The injection site should be rotated each time to avoid irritation of the skin. It should not be mixed with other types of insulin.

Side Effects

Some of the common side effects associated with proto-biphasic insulin aspart include dizziness, blurred vision, headache, and nausea. Uncommon side effects can include skin reactions at the injection site, weight gain, fluid retention, and low blood sugar levels. If side effects occur, consult a doctor promptly.

Toxicity

The maximum recommended dose of biphasic insulin aspart is 90 units per day. Higher doses can lead to an increased risk of hypoglycemia (low blood glucose levels). Severe hypoglycemia can lead to seizures, unconsciousness, and in rare cases, death. If overdose is suspected, seek help immediately.

Precautions

Before using biphasic insulin aspart, it is important to consult with a doctor or pharmacist. Some people with certain medical conditions or taking certain medications may be at increased risk of developing side effects from this medication.

Interaction

Certain medications have been shown to interact with biphasic insulin aspart. Some of these medications include 12-alpha-hydroxylase inhibitors, aminoglycosides, foscarnet, and non-steroidal anti-inflammatory drugs. Additionally, alcohol can increase the risk of hypoglycemia. Therefore, it is important to speak to a doctor about possible drug interactions before using this medication.

Disease Interaction

Certain medical conditions may interact with biphasic insulin aspart. This includes people with liver or kidney problems, pancreatic cancer, adrenal or pituitary gland disorder, congestive heart failure, hypoglycemia, or a history of a recent heart attack. Speak to a doctor before using this medication if you have any of these conditions.

Drug Interaction

Biphasic insulin aspart may interact with other medications. This includes medications that are taken to treat diabetes, drugs that can increase blood glucose levels, and drugs that can affect the immune system. Before taking this medication, it is important to speak to a doctor about possible drug interactions.

Food Interactions

Certain foods should be avoided or taken in moderation when taking biphasic insulin aspart. Foods that are high in fat, sugar, or carbohydrates may increase or lower the effects of this medication. Additionally, alcohol can increase the risk of hypoglycemia. It is important to speak to a doctor or dietitian about which foods to avoid.

Pregnancy Use

It is not recommended to take this medication during pregnancy due to a lack of data on its effects. Therefore, it is important to speak to a doctor before taking this medication if you are pregnant.

Lactation Use

Biphasic insulin aspart is a pregnancy category C medication, meaning that it is not recommended for use during breastfeeding. The effects of this medication on infants are unknown, and it may be passed through breast milk. Speak to a doctor before taking this medication if you are breastfeeding.

Acute Overdose

If an overdose is suspected, seek emergency medical attention. An acute overdose of biphasic insulin aspart can result in hypoglycemia (low blood glucose levels). It can cause seizures, unconsciousness, and in rare cases, death.

Contraindication

Biphasic insulin aspart should not be used in people with certain medical conditions. These include people with an allergy to insulin, diabetic ketoacidosis, liver problems, or if the person is taking a drug that affects insulin levels.

Use Direction

Biphasic insulin aspart should be used as directed by a healthcare provider. The dosage and the route of administration will vary depending on the severity of the condition and individual needs. Be sure to follow the doctor’s instructions carefully.

Storage Condition

Biphasic insulin aspart should be stored at room temperature in a dry place, away from light and heat. It should not be frozen.

Volume of Distribution

The volume of distribution of biphasic insulin aspart is not known. It is likely to be distributed throughout the body, as insulin typically binds to a wide range of body tissues.

Half Life

The half-life of biphasic insulin aspart is typically 3-5 hours. This means that the insulin will start to lose its effects after 3-5 hours after injection.

Clearance

The clearance of biphasic insulin aspart is not known. It is metabolized by the liver and is excreted through the kidneys and gastrointestinal tract.

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