AFM-Plus

AFM-Plus Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? AFM-Plus is a brand name. Its generic name is Fluorometholone + Gentamicin.

AFM-Plus: Introduction

Fluorometholone + gentamicin is a combination of medicines used to treat eye infections. Fluorometholone is a synthetic, steroidal glucocorticoid and an anti-inflammatory agent while gentamicin is an aminoglycoside antibiotic. This combination is used to treat bacterial infections of the eye such as eye conjunctivitis, keratitis, and anterior uveitis.

AFM-Plus: Uses

Fluorometholone + gentamicin is used to treat bacterial eye infections such as conjunctivitis, keratitis, and anterior uveitis. It is also used for other inflammatory and allergic conditions of the eye.

AFM-Plus: Mechanism of Action

Fluorometholone is a glucocorticoid which acts by mimicking the action of endogenous glucocorticoids like cortisol. It has anti-inflammatory and Vasoconstrictive action which helps in reducing swelling and pain. Gentamicin is an aminoglycoside antibiotic which kills bacteria by inhibiting bacterial protein synthesis and disrupting bacterial cell membranes.

AFM-Plus: How Long Does It Take to Work?

Fluorometholone + gentamicin takes about two to four weeks to show improvement in the symptoms of eye infections.

AFM-Plus: Absorption

Fluorometholone is absorbed through the ocular route.

AFM-Plus: Route of Elimination

Fluorometholone is excreted through the renal route. Gentamicin is excreted through the renal route as well as through the ocular route.

AFM-Plus: Dosage

The dose of Fluorometholone + gentamicin depends on the condition of the patient. The usual recommended dose is 10 mg/ml (0.1%) Fluorometholone + 1 mg/ml (0.1%) gentamicin solution given 1-2 times a day.

AFM-Plus: Administration

Fluorometholone + gentamicin drops can be directly administered into the eye with the help of a dropper or it can be administered through a soft facial tissue placed over the eye.

AFM-Plus: Side Effects

The common side effects associated with Fluorometholone + gentamicin drops include irritation, burning, redness, and stinging in the eyes. Other rare side effects include headache, nausea, dizziness, blurred vision, and photophobia.

AFM-Plus: Toxicity

Fluorometholone + gentamicin, when taken in high doses, can be toxic to the body. There may be an increase in the risk of red cell destruction, renal damage, hearing impairment, and vertigo if taken in high doses.

AFM-Plus: Precaution

Fluorometholone + gentamicin should not be used in patients with a history of allergic reactions, eye infections, renal dysfunction, or with neurological disorders. It should also be used with caution in pregnant and lactating women.

AFM-Plus: Interaction

Fluorometholone + gentamicin may interact with other drugs like diuretics, anticoagulants, and drugs metabolized through the cytochrome P450 pathway.

AFM-Plus: Disease Interaction

Fluorometholone + gentamicin may interact with certain diseases like hypoglycemia, diabetes, hypothyroidism, glaucoma, and fungal infections.

AFM-Plus: Drug Interaction

Fluorometholone + gentamicin may interact with other drugs like antibiotics, antifungal drugs, antihistamines, and glucocorticoids.

AFM-Plus: Food Interactions

Fluorometholone + gentamicin may interact with certain food substances like alcohol, caffeine, iron, and vitamin supplements.

AFM-Plus: Pregnancy Use

Fluorometholone + gentamicin is not recommended during pregnancy as it may cause harmful side effects to the fetus.

AFM-Plus: Lactation Use

Fluorometholone + gentamicin is not recommended during lactation as it may cause harmful effects to the nursing infant.

AFM-Plus: Acute Overdose

In case of an acute overdose of Fluorometholone + gentamicin, the person should be immediately taken to a hospital and should seek medical attention.

AFM-Plus: Contraindication

Fluorometholone + gentamicin is contraindicated in patients with known hypersensitivity to steroids or gentamicin.

AFM-Plus: Dosage Direction

Fluorometholone + gentamicin should be applied as a thin film on the eye. The drops should not be applied more than 2 times a day and the eye should not be rinsed after application.

AFM-Plus: Storage Condition

Fluorometholone + gentamicin should be stored at room temperature.

AFM-Plus: Volume of Distribution

The volume of distribution of Fluorometholone + gentamicin is not known.

AFM-Plus: Half Life

The half-life of Fluorometholone + gentamicin is not known.

AFM-Plus: Clearance

The clearance of Fluorometholone + gentamicin is not known.

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