Advel Tablet

Brand Name: Advel
Generic: Ibuprofen
Weight: 400 mg
Type: Tablet
Therapeutic Class: Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Manufacturer: Opsonin Pharma Ltd.
Price: 1.76
Last Updated: 2020-11-21 18:15:00
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Advel Tablet Uses

Advel Tablet contains Ibuprofen. Advel uses:

Advel Tablet is indicated

  • For the treatment of sign and symptoms of rheumatoid arthritis, ankylosing spondylitis, osteoarthritis and other non-rheumatoid arthropathies,
  • For the treatment of non-articular rheumatic conditions, such as frozen shoulder, bursitis, tendinitis, tenosynovitis and low back pain,
  • For the treatment of soft tissue injuries such as sprain, strain and post operative pain
  • For the treatment of dysmenorrhoea,
  • For the treatment of dental pain.
  • For the treatment of cold & fever.

Advel Tablet Doses

Advel Tablet contains Ibuprofen 400 mg. Advel doses:

Oral Administrations-

For Children:

  • 20 mg per kg body weight daily in divided doses. In children weighing less than 30 kg the total daily dosage should not exceed 500 mg. If gastrointestinal disturbances occur Advel Tablet should be given with food or milk.
  • 1-2 years: 1/2 tea spoonful (2.5 ml) 3-4 times daily;
  • 3-7 years: 1 tea spoonful (5 ml) 3-4 times daily;
  • 8-12 years: 2 tea spoonful (10 ml) 3-4 times daily. Advel Tablet is not recommended for children under 1 year.

For adult:

  • For arthritic pain: The dosage range is from 0.9 to 2.4 g per day. The usual dose is 400 mg, 3-4 times per day, preferably after food. The dose may be raised to a maximum of 2.4 g daily depending on the severity of symptom at the time of initiating drug therapy or as patients fail to respond. After a satisfactory response has been achieved the patients dose should be reviewed and adjusted as required and tapered gradually.
  • For mild to moderate pain: 400 mg 6 hourly or as demanded by the condition.
  • For dysmenorrhoea: 400 mg every 4 hours or as demanded by the condition.

Topical Administrations-

Pain and inflammation associated with musculoskeletal and joint disorder: As 5% cream, foam, gel, spray soln or 10% gel: Apply onto affected area.

 

Side Effects

Usually Advel Tablet has a low incidence of side effects. The most frequent side effects are gastrointestinal disturbances. Peptic ulceration and gastrointestinal bleeding have occasionally been reported. Other side effects include headache, dizziness, nervousness, skin rash, pruritus, drowsiness, insomnia, blurred vision and other ocular reactions, hypersensitivity reaction, abnormal liver function test, impairment of renal function, agranulocytosis and thrombocytopenia.

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Introduction

Advel Tablet is a non-selective inhibitor of cyclooxygenase, an enzyme invovled in prostaglandin synthesis via the arachidonic acid pathway. Its pharmacological effects are believed to be due to inhibition cylooxygenase-2 (COX-2) which decreases the synthesis of prostaglandins involved in mediating inflammation, pain, fever and swelling. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Inhibition of COX-1 is thought to cause some of the side effects of ibuprofen including GI ulceration. Advel Tablet is administered as a racemic mixture. The R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo. The S-enantiomer is believed to be the more pharmacologically active enantiomer.

Advel Precaution

Advel Tablet should be given with caution to patients with bleeding disorders, cardiovascular diseases, peptic ulceration or a history of such ulceration and in those who are receiving coumarin anticoagulants and in patients with renal or hepatic impairment.

Interaction

Increased risk of GI bleeding with warfarin, corticosteroids, SSRIs and aspirin. May reduce the natriuretic effects of diuretics. Reduced antihypertensive effect of ACE inhibitors and angiotensin II receptor antagonists. May increase toxicity of lithium and methotrexate. Increased nephrotoxicity with ciclosporin and tacrolimus.

Pregnancy Lactation use

Advel Tablet is not recommended during pregnancy or for use in nursing mothers.

Contraindication

Advel Tablet should not be given to patients with hypersensitivity to lbuprofen and to individuals who show nasal polyps, angioedema, bronchospastic reactivity to aspirin or other non-steroidal anti-inflammatory drug. Advel Tablet is contraindicated in patients with active or previous peptic ulceration & gastro-intestinal ulceration or bleeding.

Special Warning

 

Acute Overdose

Gastric lavage, correction of blood electrolytes (if necessary). There is no specific antidote for Advel Tablet

Interaction with other Medicine

 

Storage Condition

Keep in a cool & dry place. Keep out of the reach of children.

Advel Tablet price in Bangladesh 1.76

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