Adrinoxyl
Adrinoxyl Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Adrinoxyl is a brand name. Its generic name is Adrenochrome Monosemicarbazone.
Adrinoxyl Introduction
Adrinoxyl (AMSC) is a drug that has been used to treat glaucoma since the 1940s. It is a smooth muscle relaxant, which makes it potentially useful in treating any condition involving abnormal muscle tension. AMSC is a derivative of adrenochrome, and is closely related to the anti-glaucoma drug pilocarpine.Uses and Mechanism of Action
AMSC is primarily used as an ophthalmic medication to treat glaucoma by reducing intraocular pressure (IOP). It works by reducing the amount of aqueous humor in the eye, which can lead to elevated IOP. It also has potential applications in treating conditions such as migraine headaches, gastroesophageal reflux disease (GERD), raynaud's phenomenon, bronchial asthma, and muscular spasm.How Long Does it Take to Work and Absorption
AMSC typically takes between 5 minutes to 1 hour to reduce IOP and symptoms of glaucoma. It is rapidly absorbed after administration, with peak levels reached within 30 minutes of administration.Route of Elimination and Dosage
The primary route of elimination for AMSC is renal, with 60-70% of the drug being excreted unchanged in the urine. The recommended dose of AMSC to treat glaucoma is 1-5 drops per affected eye, two to four times daily.Administration, Side Effects, Toxicity, and Precaution
AMSC should be administered in the affected eye or eyes as an ophthalmic drop. Common side effects include redness, stinging, burning, and watery eyes. Oral ingestion of AMSC may cause headaches, blurred vision, dizziness, nausea, and vomiting. Overdoses of AMSC can lead to CNS depression, respiratory depression, and sympathetic overactivity, however, these effects are rare. Patients should take caution when administering AMSC, as it can cause blurred vision which may lead to an increased risk of falls and other accidents.Interactions, Disease Interactions, Drug Interactions, and Food Interactions
AMSC may interact with certain medications, diseases, and foods. It may interact with other ophthalmic medications, such as antibiotics, corticosteroids, and mydriatics. It may also interact with diseases such as diabetes or hypertension. AMSC has been shown to decrease the effectiveness of certain antihypertensive medications. It can also interact with certain foods, such as caffeine, alcohol, and spicy food.Pregnancy & Lactation Use, Acute Overdose, Contraindications, & Use Directions
AMSC is contraindicated in patients who are pregnant or lactating, as it may cause harm to the fetus or infant. It is also contraindicated in patients with a known hypersensitivity to the drug or any of its components. In the case of an overdose, contact a poison control center or seek immediate medical attention. Patients should not touch the tip of the container to any surface, as this can contaminate the medication. Patients should also avoid wearing contact lenses before administering the medication.Storage Conditions, Volume of Distribution, Half Life, & Clearance
AMSC should be stored at room temperature away from direct sunlight and moisture. The volume of distribution is 7.0 L/kg, the half-life is 2.3 hours, and the clearance is 0.51 mL/min/kg.Here you find in details version of Adrinoxyl