Adovir Tablet

Brand Name: Adovir
Generic: Adefovir Dipivoxil
Weight: 10 mg
Type: Tablet
Therapeutic Class: Hepatic viral infections (Hepatitis B)
Manufacturer: Renata Limited
Price: 14.00
Last Updated: 2020-11-20 18:15:00
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Adovir Tablet Uses

Adovir Tablet contains Adefovir Dipivoxil. Adovir uses:

Adovir Tablet is indicated for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.

Adovir Tablet Doses

Adovir Tablet contains Adefovir Dipivoxil 10 mg. Adovir doses:

The recommended dose of Adefovir for the treatment of chronic hepatitis B in adolescent & adults (age ≥ 12 year) with adequate renal function is 10 mg, once daily, taken orally, without regard to food

Dose Adjustment in Renal Impairment: Significantly increased drug exposures are seen when Adovir Tablet is administered to patients with renal impairment. Therefore, the dosing interval of Adovir Tablet should be adjusted in patients with baseline creatinine clearance < 50 mL/min using the following suggested guidelines-

Dosing interval adjustment of Adefovir in patients with renal impairment

Creatinine clearance(mL/min)

> 50

20 to 49

10 to 19

< 10 Hemodialysis or CAPD

Recommended dose and dosing interval

10 mg every 24 hours

10 mg every 48 hours

10 mg every 72 hours

10 mg every 7 days

 

Side Effects

Treatment-related clinical adverse events that occurred in 3% or greater of Adovir Tablet-treated patients compared with placebo are asthenia, headache, abdominal pain, nausea, flatulence, diarrhea, dyspepsia.

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Introduction

Adefovir is an acyclic nucleotide analogue of adenosine monophosphate. Adefovir is phosphorylated to the active metabolite, Adefovir diphosphate, by cellular kinases. Adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA.

Adovir Precaution

Severe acute exacerbation of hepatitis has been reported in patients who have discontinued anti-hepatitis B therapy, including therapy with Adovir Tablet. Patients who discontinue Adovir Tablet should be monitored at repeated intervals over a period of time for hepatic function. If appropriate, resumption of anti-hepatitis B therapy may be warranted.

Chronic administration of Adovir Tablet (10 mg once daily) may result in nephrotoxicity. The overall risk of nephrotoxicity in patients with adequate renal function is low.

However, this is of special importance in patients at risk of or having underlying renal dysfunction and patients taking concomitant nephrotoxic agents such as cyclosporine, tacrolimus, aminoglycosides, vancomycin and non-steroidal anti-inflammatory drugs.

Interaction

The pharmacokinetics of adefovir was unchanged when adefovir dipivoxil was coadministered with lamivudine, trimethoprim/ sulfamethoxazole and acetaminophen. When adefovir dipivoxil was co-administered with ibuprofen (800 mg three times daily), increases in adefovir Cmax (33%), AUC (23%) and urinary recovery were observed due to higher oral bioavailability of adefovir.

Pregnancy Lactation use

Pregnancy: There are no adequate and well-controlled studies in pregnant women. Therfore, Adovir Tablet should be used during pregnancy only if clearly needed and after careful consideration of the risks and benefits.

Lactation: It is not known whether Adefovir is excreted in human milk. Mothers should be instructed not to breast-feed if they are taking Adovir Tablet.

Pediatric Use

Safety and effectiveness in pediatric patients have not been established.

Geriatric Use

In general, caution should be exercised when prescribing to elderly patients since they have greater frequency of decreased renal or cardiac function due to concomitant disease or other drug therapy.

Contraindication

Adefovir dipivoxil is contraindicated in patients with previously demonstrated hypersensitivity to any of the components of the product.

Special Warning

Pediatric use: Safety and effectiveness in pediatric patients have not been established.

Geriatric use: In general, caution should be exercised when prescribing to elderly patients since they have greater frequency of decreased renal or cardiac function due to concomitant disease or other drug therapy.

Dose Adjustment in Renal Impairment: the dosing interval of Adefovir should be adjusted in patients with baseline creatinine clearance <50 ml/min using the following suggested guidelines:

  • CrCl ≤ 50 ml/min: 10 mg
  • CrCl 20-49 ml/min: 10 mg every 48 hours
  • CrCl 10-19 ml/min: 10 mg every 72 hours
  • Haemodialysis patients: 10 mg every 7 days following dialysis
Acute Overdose

If overdose occurs the patient must be monitored for evidence of toxicity, and standard supportive treatment applied as necessary.

Interaction with other Medicine

 

Storage Condition

Store at cool and dry place. Protect from light and moisture. Keep all the medicines out of the reach of children.

Adovir Tablet price in Bangladesh 14.00

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