Adarbi Tablet

Brand Name: Adarbi
Generic: Azilsartan Medoxomil
Weight: 40 mg
Type: Tablet
Therapeutic Class: Angiotensin-ll receptor blocker
Manufacturer: NIPRO JMI Pharma Ltd.
Price: 16.80
Last Updated: 2020-11-21 18:15:00

Adarbi Tablet Uses

Adarbi Tablet contains Azilsartan Medoxomil. Adarbi uses:

Azilsartan is an angiotensin II receptor blocker (ARB) indicated for the treatment of hypertension to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including the class to which this drug principally belongs. There are no controlled trials demonstrating risk reduction with Azilsartan.

Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than one drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program's Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC).

Adarbi Tablet Doses

Adarbi Tablet contains Azilsartan Medoxomil 40 mg. Adarbi doses:

The recommended dose in adults is 80 mg taken orally once daily. Consider a starting dose of 40 mg for patients who are treated with high doses of diuretics. If blood pressure is not controlled with Azilsartan alone, additional blood pressure reduction can be achieved by taking Azilsartan with other antihypertensive agents. Azilsartan may be taken with or without food


Side Effects

Dizziness, diarrhoea, increased blood creatinine.


Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzymes (ACE, kinase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Azilsartan medoxomil is an orally administered prodrug that is rapidly converted by esterases during absorption to the active moiety, azilsartan. Azilsartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is, therefore, independent of the pathway for angiotensin II synthesis.

An AT2 receptor is also found in many tissues, but this receptor is not known to be associated with cardiovascular homeostasis. Azilsartan has more than a 10,000-fold greater affinity for the AT1 receptor than for the AT2 receptor.

Blockade of the renin-angiotensin system with ACE inhibitors, which inhibit the biosynthesis of angiotensin II from angiotensin I, is widely used in the treatment of hypertension. ACE inhibitors also inhibit the degradation of bradykinin, a reaction catalyzed by ACE. Because azilsartan does not inhibit ACE (kinase II), it should not affect bradykinin levels. Whether this difference has clinical relevance is not yet known. Azilsartan does not bind to or block other receptors or ion channels known to be important in cardiovascular regulation.

Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increased plasma renin activity and angiotensin II circulating levels do not overcome the effect of azilsartan on blood pressure.

Adarbi Precaution

CHF, severe renal & hepatic impairment, ESRD, renal artery stenosis. Ischaemic cardiomyopathy or ischaemic cerebrovascular disease. Salt-depleted patients, primary hyperaldosteronism. Monitor serum K in patients taking K-sparing diuretics, salt substitutes containing K & drugs that increase K levels (eg, heparin) & creatinine levels in patients with renal impairment & DM. Aortic or mitral valve stenosis, hypertrophic obstructive cardiomyopathy.


Reversibly increases serum concentration & toxicity of lithium; attenuated antihypertensive effects & risk of worsening of renal function may occur with NSAIDs. Hyperkalemia with K-sparing diuretics & K supplements.

Pregnancy Lactation use

Pregnancy Category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).


Hypersensitivity. Concomitant use with aliskiren. Pregnancy (2nd & 3rd trimester).

Special Warning


Acute Overdose


Interaction with other Medicine


Storage Condition


Adarbi Tablet price in Bangladesh 16.80