একুডিল এ আছে Racecadotril। একুডিল এর কাজঃ
একুডিল is indicated for the symptomatic treatment of acute diarrhea.
একুডিল is a pure intestinal antisecretory active substance. It decreases the intestinal hypersecretion of water and electrolytes induced by cholera toxin or inflammation and does not have effects on basal secretory activity.
Following oral administration, একুডিল is rapidly absorbed and then hydrolysed to thiorphan, which is an inhibitor of enkephalinase, a cell membrane peptidase located in various tissues, notably the epithelium of the small intestine. This enzyme contributes both to the hydrolysis of exogenous peptides and to the breakdown of endogenous peptides such as enkephalins. একুডিল protects enkephalins from enzymatic degradation thereby prolonging their action at enkephalinergic synapses in the small intestine and reducing hypersecretion. একুডিল exerts rapid antidiarrhoeal action, without modifying the duration of intestinal transit.
|Acudi Capsule 100 mg in bangla|
|উৎপাদনকারীঃ||Pacific Pharmaceuticals Ltd|
|সর্বশেষ সম্পাদনাঃ||2020-11-22 18:15:00|
একুডিল increases the availability of endogenous opioids (enkephalins) by inhibiting the membrane-bound enkephalinase. The enkephalins in turn mediate their effect through δ receptor ( delta opioid receptor) activation that induces a selective increase in Cl absorption by inhibiting adenylate cyclase.
Onset: 30 min (plasma enkephalinase inhibition).
একুডিল এ আছে Racecadotril 100 mg। একুডিল খাওয়ার নিয়ম নিম্নরূপঃ
Adults: One capsule initially, regardless of the time of day. Then one capsule three times daily preferably before the main meals.
Children (from 3 months of age): একুডিল granules should be administered together with oral rehydration. The recommended dose is determined according to body weight: 1.5 mg/kg per administration, three times daily.
Headache, erythema multiforme, urticaria, angioedema may be seen.
The administration of একুডিল does not modify the usual rehydration regimens. The presence of bloody stools and fever may indicate the presence of invasive bacteria as a reason for diarrhea or the presence of other severe disease. একুডিল has not been tested in antibiotic-associated diarrhea and should therefore not be administered under these conditions. Caution should be taken in patients with renal or liver impairment.
No drug interactions found. Joint treatment with একুডিল and Loperamide or Nifuroxazide does not modify the kinetics of একুডিল.
Due to a lack of clinical data, একুডিল should not be administered to pregnant or breastfeeding women.
Hypersensitivity to একুডিল, or to any of the excipients.
No cases of overdose have been reported. In adults, single doses above 2 g which is equivalent to 20 times the therapeutic dose, have been administered, and no harmful effects have been described.
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