Actifed, a brand name for a formulation containing essential Pseudoephedrine + Triprolidine, is widely used for various health benefits. This guide provides comprehensive information on the uses, dosage, side effects, and mechanism of action of Actifed, as well as insights into how long it takes to work. Understanding these aspects can help you make informed decisions about its use and effectiveness.


Pseudoephedrine and Triprolidine are an antihistamine-decongestant combination drug used to treat allergies, cold or flu symptoms. Pseudoephedrine is a decongestant and Triprolidine is an antihistamine. Pseudoephedrine-Triprolidine is usually available in tablet or liquid form.


Pseudoephedrine-Triprolidine is typically used to relieve nasal congestion and coughing that comes with allergies, the common cold, or the flu.

Mechanism of Action

The combination of Pseudoephedrine and Triprolidine makes Pseudoephedrine-Triprolidine a unique and extremely effective medication. Pseudoephedrine belongs to a class of drugs called sympathomimetics, which work to reduce swelling and congestion in the nasal passages by narrowing small blood vessels in the lining of the nose. Triprolidine, an antihistamine, blocks the effects of histamine, a chemical in the body that causes allergic symptoms. Together, Pseudoephedrine and Triprolidine work to reduce the symptoms of allergies, colds and flus.

How Long Does It Take to Work?

Pseudoephedrine-Triprolidine works quickly to provide relief from nasal congestion and coughing. Most users will experience relief in less than one hour after taking the medication.


Pseudoephedrine-Triprolidine is quickly and easily absorbed, with peak levels occurring in approximately 2 hours.

Route of Elimination

Pseudoephedrine-Triprolidine is mainly excreted by the kidney.


The recommended dose of Pseudoephedrine-Triprolidine depends on the individual, and it can range from 1 to 2 tablets (or 5 to 15 mL of liquid) every 4-6 hours. It is important to not exceed the recommended dosage as side effects can occur.


Pseudoephedrine-Triprolidine is typically taken by mouth with a glass of water. It can also be taken with food to reduce the risk of stomach upset.

Side Effect

Common side effects of Pseudoephedrine-Triprolidine can include headache, drowsiness, nausea, vomiting, and dizziness.


At therapeutic doses, Pseudoephedrine-Triprolidine is generally considered to be safe. In cases of overdose, symptoms can include restlessness, agitation, seizures, hallucinations, and irregular heartbeat. It is important to seek immediate medical attention if any of these symptoms occur.


Pseudoephedrine-Triprolidine should be used with caution in people with pre-existing hypertension, heart disease, diabetes, organ transplant, glaucoma, and hyperthyroidism. Those with severe liver or kidney diseases should not take this medication.


Pseudoephedrine-Triprolidine may interact with other medications, including beta-blockers, MAO inhibitors, anti- seizure medications, diuretics, and herbal supplements. It is important to tell your doctor about all medications and supplements you are taking before taking Pseudoephedrine-Triprolidine.

Disease Interactions

People with certain diseases, such as hypertension, diabetes, hyperthyroidism, and glaucoma, may need to adjust their dosage or avoid taking Pseudoephedrine-Triprolidine altogether.

Drug Interactions

Pseudoephedrine-Triprolidine may interact with other drugs, such as MAO inhibitors, beta-blockers, anti-seizure medications, and diuretics.

Food Interactions

Pseudoephedrine-Triprolidine may interact with certain foods such as alcohol and caffeine, so these should be avoided while taking this medication.

Pregnancy Use

Pseudoephedrine-Triprolidine is not recommended for use during pregnancy. If you are pregnant or plan to become pregnant, consult your healthcare provider prior to taking Pseudoephedrine-Triprolidine.

Lactation Use

Pseudoephedrine-Triprolidine is not recommended for use during breast-feeding due to the potential for serious side effects in infant and breast-feeding mothers.

Acute Overdose

Signs and symptoms of an acute overdose may include restlessness, agitation, seizures, hallucinations, and irregular heartbeat. Seek immediate medical attention, and use supportive care and appropriate symptomatic therapy.


People with allergies to Pseudoephedrine or Triprolidine should not take this medication.

Directions for Use

Follow the directions on your prescription label or as recommended by your doctor. For best results, take Pseudoephedrine-Triprolidine at the same time each day. Avoid taking this medication if it makes you drowsy or if you are unable to safely operate a motor vehicle or heavy machinery.

Storage Condition

Pseudoephedrine-Triprolidine should be stored at room temperature in a dry location.

Volume of Distribution

Pseudoephedrine-Triprolidine is widely distributed in the body, with an estimated volume of distribution of approximately 11L/kg.

Half Life

The half-life of Pseudoephedrine-Triprolidine is approximately 5-7 hours.


Pseudoephedrine-Triprolidine has a clearance of approximately 100 mL/minute.

Here you find in details version of Actifed