Acitrin

Acitrin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Acitrin is a brand name. Its generic name is Acitretin.

Acitrin: Introduction

Acitrin (also known as Soriatane or Isotretinoin) is a retinoid and a synthetic form of vitamin A. It is used to treat psoriasis and other skin disorders, such as severe recalcitrant nodular acne, ichthyosis, and keratosis pilaris. It works by controlling the growth of skin cells, reducing swelling and inflammation, and preventing the formation of new lesions.

Uses For Acitrin

Acitrin is used to treat severe psoriasis, other skin disorders, such as severe recalcitrant nodular acne, ichthyosis, and keratosis pilaris. It can also be used to treat children who are at least two years old.

Mechanism of Action

Acitrin's mechanism of action is thought to involve multiple pathways. It binds to and activates retinoic acid receptors and influences the differentiation and proliferation of epithelial cells. In addition, it binds to nuclear receptors that reduce proinflammatory cytokines and enhance the production of anti-inflammatory cytokines. Acitrin also modulates collagen metabolism and changes the biosynthesis of epidermal lipids.

How Long Does It Take to Work?

Acitrin generally takes up to 8 weeks to start showing effects, but some people notice results sooner. It is important to follow your doctor's instructions carefully and take the medication for the correct duration of time in order to get the best results.

Absorption

Acitrin is rapidly and completely absorbed from the gastrointestinal tract. It is 90% picd after a single oral dose.

Route of Elimination

Acitrin is slowly eliminated from the body, with a half-life of approximately 24 hours. The drug is metabolized by the liver and excreted mainly in the feces. Some elimination occurs through the urine as well.

Dosage, Administration, Side Effects, Toxicity, Precaution, Interactions, Disease Interactions, Drug Interactions, Food Interactions, Pregnancy Use, Lactation Use, Acute Overdose, Contraindication, Use Direction, Storage Condition, Volume of Distribution, Half Life, and Clearance

The recommended doses for acitretin vary depending on the indication, with doses of 25-50 mg/day being most common. Acitrin should not be taken with food or with a glass of milk. It should be taken with a full glass of water to ensure complete absorption. When taking acitretin, individuals should avoid exposure to sunlight or UV light and wear protective clothing. Alcohol should also be avoided during acitretin therapy. Common side effects include dry skin, joint pain, and discoloration of the skin, hair, and nails. Other side effects may include headache, drowsiness, weakness, abdominal pain, nausea, vomiting, and diarrhea. Serious side effects may include blurred vision, yellowing of the skin or eyes, skin rash, and difficulty breathing or swallowing. Acitrin has low acute and chronic toxicity. It should not be used in people who are pregnant or breastfeeding. Acitrin may interact with other medications, so all medications and supplements should be discussed with a physician prior to taking the drug. Acutetin should be stored at room temperature, away from excessive heat and light. It has a volume of distribution of ~30-70 L/kg and a half-life of approximately 24 hours. The clearance rate of acutetin is approximately 25-50 L/kg/h.

Here you find in details version of Acitrin

Some Frequently Asked Questions About Acitrin

What is Acitrin?

Acitrin is a synthetic retinoid medicine used to treat psoriasis, a skin condition that causes itchy and scaly patches on the skin. It works by acting inside skin cells to regulate skin growth and shedding. It also helps reduce inflammation, which is commonly a symptom of psoriasis.

What is Acitrin used for?

Acitrin is used for the treatment of severe psoriasis in adults that is not responding to other treatments. It can also be used to treat other skin conditions such as ichthyosis and keratosis pilaris.

What are the possible side effects of Acitrin?

The most common side effects of Acitrin are dryness, itching, redness, burning sensation, peeling of the skin, and changes in skin color. Other possible side effects may include nausea, vomiting, abdominal pain, diarrhea, headache, hair loss, and dizziness.

Is Acitrin safe to take long term?

Yes, Acitrin can be used long-term as it has been studied for up to 12 years. However, your doctor should check your progress regularly and adjust your dose as necessary.

What are the dosage instructions for Acitrin?

Your doctor will advise you on how much Acitrin to take and for how long. Follow the instructions carefully. The usual starting dose is 25 mg per day. Your doctor may increase this if necessary or depending on your response to treatment. It is recommended that you take Acitrin with or after meals.

Can I take other medicines while taking Acitrin?

Be sure to tell your doctor about all other medications you are taking, including herbal supplements and over-the-counter medications. Certain drugs can interact with Acitrin and cause serious side effects. Avoid taking vitamin A supplements or products containing high levels of vitamin A (such as multivitamins) while taking Acitrin.

Can I use other skin products while taking Acitrin?

It is best to avoid using other skin products, such as soaps, moisturizers, and cosmetics, while taking Acitrin, as they may further irritate the skin and increase unwanted side effects. Talk to your doctor before using any other skin products.

Does Acitrin interact with any other drugs?

Yes, there are a number of drugs that can interact with Acitrin. These include certain antibiotics, antifungals, and some anti-epileptic drugs. Be sure to tell your doctor about all the medications you are taking, including any over-the-counter drugs and herbal supplements.

Does Acitrin cause birth defects?

Yes, Acitrin should not be taken during pregnancy as it is known to cause birth defects. Women of childbearing age should use effective birth control while taking Acitrin. Do not breastfeed while taking Acitrin as it can get into breast milk.

Can I drink alcohol while taking Acitrin?

It is not recommended to drink alcohol while taking Acitrin. Alcohol can increase the risk of side effects from Acitrin, such as liver damage. If you choose to drink alcohol, do so in moderation and talk to your doctor about your drinking habits.

Do I need to have liver function tests while taking Acitrin?

Yes, it is important to have regular liver function tests while taking Acitrin, as this drug can cause liver damage. You should also inform your doctor if you experience any signs of liver dysfunction, such as fatigue, yellowing of the skin, dark urine, or abdominal pain.

Do I need to have regular eye exams while taking Acitrin?

Yes, it is important to have regular eye exams while taking Acitrin. This drug can cause certain eye disorders, such as retinopathy, which can lead to vision loss. Be sure to tell your doctor of any changes in your vision.

How quickly will I see results when taking Acitrin?

The effects of Acitrin can take some time to be noticeable. It may take 4-8 weeks, or sometimes longer, to see relief of symptoms. In some cases a change in dosage may be required.

What are some other treatments for psoriasis?

There are many treatments available for psoriasis, which include topical medications, phototherapy, and systemic medications. Your doctor can help you choose the best treatment plan for your specific condition.

Can Acitrin make my psoriasis worse?

In rare cases, Acitrin can make psoriasis worse. If you experience an increase in itching, redness, flaking, or other symptoms of psoriasis, contact your doctor right away.

Are there any alternatives to Acitrin?

Yes, there are several alternatives to Acitrin. These include topical medications, phototherapy, and systemic medications. Your doctor can help you choose the most effective treatment for your specific condition.

What should I do if I miss a dose of Acitrin?

If you miss a dose of Acitrin, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time.

What should I do if I overdose on Acitrin?

If you think you have taken too much Acitrin, contact your doctor or Poison Control Center immediately. Symptoms of an overdose may include vomiting, nausea, and dizziness.

Should I avoid sun exposure while taking Acitrin?

Yes, it is important to avoid sun exposure while taking Acitrin. Sun exposure can make your skin more sensitive and this medicine can make your skin more prone to burning. Wear sunscreen and protective clothing when outdoors, and take extra care to avoid prolonged sun exposure.

Does Acitrin interact with other vitamins?

Yes, Acitrin can interact with certain vitamins. Avoid taking vitamin A supplements or products containing high levels of vitamin A (such as multivitamins) while taking Acitrin, as this can increase the risk of side effects.

Can Acitrin help with acne?

Yes, Acitrin can be used to treat severe acne. It works by decreasing the production of oil in the skin, which can help reduce the incidence of acne. Talk to your doctor if you are considering this treatment.

Does Acitrin affect hormones?

No, Acitrin does not affect hormones. This medication does not cause hormonal changes and is not known to interact with other hormonal medications.

Can I take Acitrin while pregnant?

No, Acitrin should not be taken during pregnancy as it is known to cause birth defects. If you are pregnant, or think you may be pregnant, talk to your doctor about other treatment options.

Can I get a sunburn while taking Acitrin?

Yes, Acitrin can make your skin more prone to burning from sun exposure, so it is important to take extra care when in the sun. Wear sunscreen, protective clothing, and avoid prolonged sun exposure.

Is Acitrin available in generic form?

No, Acitrin is not available in generic form. It is only available as a brand-name medication.

Can Acitrin cause allergic reactions?

Yes, Acitrin can cause allergic reactions in some people. If you experience any signs of a severe allergic reaction, such as difficulty breathing, swelling of the face and throat, or hives, stop taking Acitrin and contact your doctor right away.

What should I do if I experience severe skin irritation with Acitrin?

If you experience severe itching, burning, or redness of the skin while taking Acitrin, contact your doctor right away. Your doctor may recommend adjusting your dose or switching to a different medication.

Can Acitrin cause liver damage?

Yes, Acitrin can cause liver damage. It is important to have regular liver function tests while taking Acitrin and to inform your doctor if you experience any signs of liver dysfunction, such as fatigue, yellowing of the skin, dark urine, or abdominal pain.

Can Acitrin be used alongside phototherapy?

Yes, Acitrin can be used alongside phototherapy. Your doctor should monitor for any signs of irritation or adverse reactions with both treatments.

Can Acitrin help reduce inflammation associated with psoriasis?

Yes, Acitrin can help reduce inflammation associated with psoriasis. This medication works by regulating skin growth and shedding and reducing inflammation, which can help reduce the severity of psoriasis symptoms.

Can children take Acitrin?

Yes, Acitrin can be used to treat psoriasis in children over 10 years of age. Your doctor can advise you on the appropriate dose and duration of treatment for your child.

Does Acitrin cause weight gain?

No, Acitrin is not known to cause weight gain. However, some people may experience weight changes while taking Acitrin, so you should talk to your doctor if you experience any unwanted weight changes.

Can I take Acitrin while breastfeeding?

No, Acitrin should not be taken while breastfeeding as it can get into breastmilk. If you plan to breastfeed while taking Acitrin, talk to your doctor first.

Can Acitrin cause vision loss?

Yes, Acitrin can cause certain eye disorders, such as retinopathy, which can lead to vision loss. It is important to have regular eye exams while taking Acitrin and to tell your doctor of any changes in your vision.

What precautions should I take when taking Acitrin?

It is important to take the following precautions when taking Acitrin: Avoid sun exposure; avoid drinking alcohol; avoid taking other medications, including over-the-counter drugs and herbal supplements; do not take vitamin A supplements; and do not use other skin products, such as soaps, moisturizers, and cosmetics.

Do I need to avoid certain foods while taking Acitrin?

No, there are no specific foods that you should avoid while taking Acitrin. However, it is wise to avoid alcohol and beef liver, as these can increase the risk of side effects. Talk to your doctor if you have any questions.

Do I still need to use psoriasis treatments while taking Acitrin?

Yes, it is important to continue using topical and systemic psoriasis treatments while taking Acitrin. Your doctor can advise you on the best treatment plan for your condition.

Will my psoriasis symptoms come back if I stop taking Acitrin?

Yes, it is possible for psoriasis symptoms to come back when Acitrin is stopped. Your doctor will advise you on how long to keep taking Acitrin and will recommend follow-up treatments to help keep your psoriasis under control. Contact your doctor if you experience a recurrence of symptoms after stopping Acitrin.