Acerux-H Cream contains Acyclovir + Hydrocortisone. Acerux-H Cream is used for:
Aciclovir & Hydrocortisone Cream is indicated for the early treatment of recurrent herpes labialis (cold sores) to reduce the likelihood of ulcerative cold sores and to shorten the lesion healing time in adults and children (6 years of age and older).
Aciclovir is a synthetic purine nucleoside analogue with inhibitory activity against Herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) in cell culture and in vivo. The inhibitory activity of Aciclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV. This viral enzyme converts Aciclovir into Aciclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. In cell culture, Aciclovir Triphosphate stops replication of herpes viral DNA. This inhibition is accomplished in 3 ways:
Hydrocortisone is the main glucocorticoid secreted by the adrenal cortex. It is used topically for its anti-inflammatory effects which suppress the clinical manifestations of the disease in a wide range of disorders where inflammation is a prominent feature.
Hydrocortisone & Combined preparations
The cream should be topically applied 5 times per day for 5 days. Therapy should be initiated as early as possible after the first signs and symptoms.
The following most common adverse reactions (<1%) were local skin reactions like drying or flaking of the skin; burning or tingling, erythema; pigmentation changes, application site reactions including signs and symptoms of inflammation.
Aciclovir and Hydrocortisone should not be used in the eye, inside the mouth or nose, or on the genitals. Patients should seek medical advice when a cold sore fails to heal within 2 weeks.
Pregnancy Category B. There are no adequate and well-controlled studies of systemic Aciclovir in pregnant women. No studies have been performed in pregnant women. Systemic exposure of Aciclovir and Hydrocortisone following topical administration of this cream is minimal.
It is not known whether topically applied Aciclovir or Hydrocortisone is excreted in breast milk. Because many drugs are excreted in human milk, caution should be exercised when administered to a nursing woman.
There is no known contraindication.
Safety and effectiveness in pediatric subjects less than 6 years of age have not been established.
Acerux-H Cream price in Bangladesh 98