Abcliz Tablet contains Meclizine + Pyridoxine. Abcliz Tablet is used for:
For prophylaxis and symptomatic relief of nausea, vomiting, dizziness, motion sickness, radiation sickness and vertigo associated with diseases of vestibular motion sickness, radiation sickness and vertigo associated with diseases of vestibular system, morning sickness during pregnancy, drug induced nausea, vomiting induced by oral contraceptives or Estrogen preparations.
Meclizine has antiemeitic, anticholinergic and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers.
Pyridoxine Hydrochloride (Vit - B6), either alone or combination has been used to prevent nausea & vomiting due to its antiemetic properties.
The fixed-dose combination is recommended for oral administration-
Nausea & vomiting (including morning sickness in pregnancy): One tablet 1-2 times daily.
Motion sickness: One or two tablets one hour prior to journey. The dose may be repeated every 24 hours as indicated for the duration of journey.
Vertigo: One tablet 2 times daily or as directed by physician.
Labyrinthine and vestibular disturbances: The optimal dose of Meclizine Hydrochloride is usually 25 to 100 mg daily in divided doses, depending on the clinical response.
Radiation sickness: 50 mg (Meclizine Hydrochloride) administered 2 to 12 hours prior to radiation treatment. Pyridoxine Hydrochloride (vitamin B6) has been shown to be safe and effective in dosages of 50 to 200 mg per day.
contraceptive pill (ECP) : 25-50 mg, 1 hour before first ECP dose; repeat if needed in 24 hours.
Drowsiness, dry mouth, urinary retention in rare occasions, blurred vision has been reported. Sensory neuropathy reported with high dosage of Pyridoxine Hydrochloride given for extended periods.
Due to its potential anticholinergic action, patient with asthma, bronchitis, emphysema, enlarged prostate, glaucoma or urinary tract blockade should take Meclizine HCl (like other antiemetics) with caution.
The CNS depressant effects of Meclizine can be potentiated by concurrent use of Ethanol or other CNS depressant agents such as Benzodiazepines, Barbiturates, Tricyclic antidepressants, opiate agonists, skeletal muscle relaxants and antihistamines. Concurrent use of other anticholinergics can potentiate the anticholinergic effects of Meclizine. Meclizine can increase the absorption of digoxin by decreasing gastrointestinal motility.
Use in pregnancy: Meclizine is pregnancy Category B drug. Large-scale human studies have not demonstrated adverse fetal effects. It has been suggested that, based on available data, Meclizine presents the lowest risk of teratogenicity and is the drug of first choice in treating nausea and vomiting during pregnancy. On the other hand, Pyridoxine is pregnancy category A drug. Pyridoxine itself is considered as safe during pregnancy and has been used in pregnant women without any evidence of fetal harm.
Use in lactation: Meclizine may be distributed into breast milk. However problem in human have not been documented. On the other hand, Pyridoxine has no adverse effects during lactation.
Symptoms: Extreme excitability, seizures, drowsiness and hallucinations.
Treatment: Appropriate supportive and symptomatic treatment. Consider dialysis.
Meclizine Hydrochloride and Pyridoxine Hydrochloride is contraindicated in patients who are hypersensitive to these ingredients.
Store in a cool, dry place, away from light. Keep out of reach of children.
Use in children: Safety and efficacy have not been established in children below 2 years of age.
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