A Zide Tablet Uses
Treatment of hypertension or congestive heart failure in patients who develop hypokalemia when thiazide or other kaliuretic diuretics are used alone, or in patients in whom maintenance of normal serum potassium levels is clinically important (eg, digitalized patients); alone or as adjunctive treatment with other antihypertensive agents.
A Zide Generic
Hydrochlorothiazide + Amiloride
A Zide Introduction
Amiloride is a weak diuretic which acts mainly on the distal renal tubules. It increases the excretion of Na and reduces the excretion of K. It diminishes kaliuretic effects of other diuretics, and may produce an additional natriuretic effect.
Hydrochlorothiazide inhibits the reabsorption of Na in the distal tubules causing increased excretion of Na and water including K and hydrogen ions.
A Zide Therapeutic Class
Thiazide diuretics & related drugs
A Zide Tablet Doses
Adult: 1-2 tablets (5 mg amiloride & 50 mg hydrochlorothiazide) daily in single or divided doses, increasing if necessary to maximum 4 tablets.
Children: Safety and efficacy not established.
A Zide Accute Overdose
Symptoms: Dehydration, electrolyte imbalance (eg, hyperkalemia), electrolyte depletion (hypokalemia, hypochloremia, hyponatremia).
A Zide Contraindication
Hyperkalemia (serum potassium levels greater than 5.5 mEq/L); concurrently with other potassium-sparing diuretics (eg, spironolactone), potassium supplements (including potassium-rich diet) except in severe or refractory cases of hypokalemia; impaired renal function; sensitivity to any components of product.
A Zide Storage Condition
Store tablets at controlled room temperature (59° to 86°F). Protect from moisture, freezing, and excessive heat.