A Zide Tablet


Generic: Hydrochlorothiazide + Amiloride
Weight: 50 mg+5 mg
Price: 0
Manufacturer: Acme Laboratories Limited.
Last Updated: 2020-08-12 18:15:00

A Zide Tablet Uses

A Zide Tablet contains Hydrochlorothiazide + Amiloride. A Zide Tablet is used for:

Treatment of hypertension or congestive heart failure in patients who develop hypokalemia when thiazide or other kaliuretic diuretics are used alone, or in patients in whom maintenance of normal serum potassium levels is clinically important (eg, digitalized patients); alone or as adjunctive treatment with other antihypertensive agents.

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Generic

Introduction

Amiloride is a weak diuretic which acts mainly on the distal renal tubules. It increases the excretion of Na and reduces the excretion of K. It diminishes kaliuretic effects of other diuretics, and may produce an additional natriuretic effect.

Hydrochlorothiazide inhibits the reabsorption of Na in the distal tubules causing increased excretion of Na and water including K and hydrogen ions.

Therapeutic Class

Thiazide diuretics & related drugs

A Zide Tablet Doses

Adult: 1-2 tablets (5 mg amiloride & 50 mg hydrochlorothiazide) daily in single or divided doses, increasing if necessary to maximum 4 tablets.

Children: Safety and efficacy not established.

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Administrations

A Zide Tablet Side Effects

  • Cardiovascular: Arrhythmia, tachycardia, palpitations (amiloride).
  • CNS: Headache, fatigue, tiredness, weakness, dizziness, encephalopathy, tremors, decreased libido (amiloride); restlessness (hydrochlorothiazide).
  • Dermatologic: Mild skin rash, pruritus, alopecia (amiloride); urticaria, purpura (hydrochlorothiazide).
  • EENT (eye, ear, nose, and throat): Increased ocular pressure, tinnitus (amiloride); transient blurred vision, xanthopsia (hydrochlorothiazide).
  • GI: Nausea, anorexia, GI and abdominal pain, flatulence, activation of peptic ulcer, dyspepsia, heartburn, dry mouth (amiloride); pancreatitis, cramping, GI irritation, sialadenitis (hydrochlorothiazide).
  • Genitourinary: Bladder spasm, polyuria, urinary frequency (amiloride); interstitial nephritis (hydrochlorothiazide).
  • Hematologic: Aplastic anemia, neutropenia (amiloride); agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia (hydrochlorothiazide).
  • Hepatic: Jaundice.
  • Metabolic: Hyperkalemia, hyperglycemia, glucosuria, hyperuricemia (hydrochlorothiazide).
  • Respiratory: Shortness of breath, cough (amiloride); respiratory distress, including pneumonitis and pulmonary edema (hydrochlorothiazide).
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Precaution

 

Interaction

  • Amiloride ACE inhibitors (eg, captopril): May result in severely elevated potassium levels.
  • Potassium preparations: May severely increase serum potassium levels, possibly resulting in cardiac arrhythmias or cardiac arrest. Do not coadminister.
  • Hydrochlorothiazide Bile acid sequestrants: May reduce thiazide absorption; give thiazide at least 2 h before sequestrant.
  • Diazoxide: May cause hyperglycemia.
  • Digitalis glycosides: Diuretic-induced hypokalemia and hypomagnesemia may lead to digitalis-induced arrhythmias.
  • Lithium: Renal excretion of lithium may be reduced.
  • Loop diuretics (eg, furosemide): Synergistic effects may occur, resulting in profound diuresis and serious electrolyte abnormalities.
  • Sulfonylureas (eg, chlorpropamide): Hypoglycemic effect of sulfonylurea may be decreased, necessitating an increase in sulfonylurea dosage.

A Zide Tablet Uses During Pregnancy

Pregnancy Category B 

Lactation: 

  • Amiloride: undetermined
  • hydrochlorothiazide: excreted in breast milk.
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Accute Overdose

Symptoms: Dehydration, electrolyte imbalance (eg, hyperkalemia), electrolyte depletion (hypokalemia, hypochloremia, hyponatremia).

Contraindication

Hyperkalemia (serum potassium levels greater than 5.5 mEq/L); concurrently with other potassium-sparing diuretics (eg, spironolactone), potassium supplements (including potassium-rich diet) except in severe or refractory cases of hypokalemia; impaired renal function; sensitivity to any components of product.

Uses Direction

 

Storage Condition

Store tablets at controlled room temperature (59° to 86°F). Protect from moisture, freezing, and excessive heat.

Special Warning

 

Interactions with other Medicine

 

A Zide Tablet price in Bangladesh 0