A-Phenicol Eye/Ear Drop


Generic: Chloramphenicol
Weight: 0.5%
Price: 32.2
Manufacturer: Acme Laboratories Limited.
Last Updated: 2020-08-08 18:15:00

A-Phenicol Eye/Ear Drop Uses

A-Phenicol Eye/Ear Drop contains Chloramphenicol. A-Phenicol Eye/Ear Drop is used for:

A-Phenicol Eye/Ear Drop is indicated in Ocular infections, Bacterial meningitis, Anaerobic bacterial infections, Anthrax, Brain abscess, Ehrlichiosis, Gas gangrene, Granuloma inguinale, Infections caused by H. influenzae, Listeriosis, Plague, Psittacosis, Q fever, Severe gastroenteritis, Severe melioidosis, Severe systemic infections with Camphylobacter fetus, Tularaemia, Whipple's disease, Otitis externa

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Generic

Introduction

A-Phenicol Eye/Ear Drop inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.

Therapeutic Class

Ear Anti-Infectives & Antiseptics, Eye Anti-Infectives & Antiseptics

A-Phenicol Eye/Ear Drop Doses

For Eye: Adults, children and infants (all age groups): One or two drops 4 to 6 times a day should be placed in the infected eyes. If necessary the frequency of dose can be increased. Treatment should be continued for approximately 7 days but should not be continued for more than three weeks without re-evaluation by the prescribing physician.

For Ear: 2 to 3 drops into ear canal thrice or four times daily.

Otic/Aural: Otitis externa: Instill 2-3 drops of a 5% solution into the ear bid-tid.

Oral: Bacterial meningitis, Anaerobic bacterial infections, Anthrax, Brain abscess, Ehrlichiosis, Gas gangrene, Granuloma inguinale, Infections caused by H. influenzae, Listeriosis, Plague, Psittacosis, Q fever, Severe gastroenteritis, Severe melioidosis, Severe systemic infections with Camphylobacter fetus, Tularaemia, Whipple's disease:

  • Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient's temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever.
  • Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections.
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Administrations

A-Phenicol Eye/Ear Drop Side Effects

Oral: GI symptoms; bleeding; peripheral and optic neuritis, visual impairment, blindness; encephalopathy, confusion, delirium, mental depression, headache. Haemolysis in patients with G6PD deficiency.

ophthalmic application: Hypersensitivity reactions including rashes, fever and angioedema. 

Ear drops: Ototoxicity.

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Precaution

Impaired renal or hepatic function; premature and full-term neonates. Monitor plasma concentrations to avoid toxicity.

Interaction

Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of A-Phenicol Eye/Ear Drop. Impairs the action of oral contraceptives.

A-Phenicol Eye/Ear Drop Uses During Pregnancy

Pregnancy Category C. Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.

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Accute Overdose

 

Contraindication

History of hypersensitivity or toxic reaction to the drug; pregnancy, lactation; porphyria; parenteral admin for minor infections or as prophylaxis; preexisting bone marrow depression or blood dyscrasias.

Uses Direction

 

Storage Condition

Cap/susp: Store at temp not exceeding 30°C. 

Ophth/otic preparation: Store between 2-8°C. Do not freeze. Protect from light.

Special Warning

 

Interactions with other Medicine

 

A-Phenicol Eye/Ear Drop price in Bangladesh 32.2