A Card SR Tablet (Sustained Release)


Generic: Isosorbide Mononitrate
Weight: 50 mg
Price: 0
Manufacturer: Acme Laboratories Limited.
Last Updated: 2020-08-14 18:15:00

A Card SR Tablet (Sustained Release) Uses

A Card SR Tablet (Sustained Release) contains Isosorbide Mononitrate. A Card SR Tablet (Sustained Release) is used for:

Isosorbide mononitrate tablets are indicated for-

  • The prevention of angina pectoris due to coronary artery disease. The onset of action of oral A Card SR Tablet (Sustained Release) is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.
  • Long-term treatment of blood-flow disorders of the coronary vessels (coronary heart disease)
  • Long-term treatment and prophylaxis of angina pectoris (chest pain due to coronary blood-flow disorders of the coronary vessels).
  • Treatment of severe myocardial insufficiency (chronic heart failure)
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Generic

Introduction

Isosorbide-5-mononitrate is an active metabolite of isosorbide dinitrate. It is a vasodilator with effects on both arteries and vein and also coronary vessels. It causes reduction of preload and afterload and redistributes coronary flow to ischemic regions.

Isosorbide mononitrate relaxes vascular smooth muscles by stimulating cyclic-GMP. It decreases left ventricular pressure (preload) and arterial resistance (afterload).

Therapeutic Class

Nitrates: Coronary vasodilators

A Card SR Tablet (Sustained Release) Doses

The recommended regimen of A Card SR Tablet (Sustained Release) tablets is 20 mg (one tablet) twice daily, with the two doses given 7 hours apart. For most patients, this can be accomplished by taking the first dose on awakening and the second dose 7 hours later. Dosage adjustments are not necessary for elderly patients or patients with altered renal or hepatic function.

Multiple studies of organic nitrates have shown that maintenance of continuous 24-hour plasma levels results in refractory tolerance. The dosing regimen for A Card SR Tablet (Sustained Release) tablets provides a daily nitrate-free interval to avoid the development of this tolerance. Well-controlled studies have shown that tolerance to A Card SR Tablet (Sustained Release) tablets is avoided when using the twice-daily regimen in which the two doses are given 7 hours apart. This regimen has been shown to have antianginal efficacy beginning 1 hour after the first dose and lasting at least 5 hours after the second dose. The duration (if any) of antianginal activity beyond 12 hours has not been studied; large controlled studies with other nitrates suggest that no dosing regimen should be expected to provide more than about 12 hours of continuous antianginal efficacy per day.

In clinical trials, A Card SR Tablet (Sustained Release) tablets have been administered in a variety of regimens. Single doses less than 20 mg have not been adequately studied, while single doses greater than 20 mg have demonstrated no greater efficacy than doses of 20 mg.

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Administrations

A Card SR Tablet (Sustained Release) Side Effects

Hypotension, tachycardia, flushing, headache, dizziness, palpitation, syncope, confusion. Nausea, vomiting, abdominal pain. Restlessness, weakness and vertigo. Dry mouth, chest pain, back pain, oedema, fatigue, abdominal pain, constipation, diarrhoea, dyspepsia and flatulence.

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Precaution

Severe renal or severe hepatic impairment, hypothyroidism, malnutrition, or hypothermia. Caution in patients who are already hypotensive. May aggravate angina caused by hypertrophic cardiomyopathy. Tolerance may develop after long-term treatment. Lactation.

Interaction

Hypotensive effects may be increased when used with alcohol or vasodilators. Concurrent use with calcium channel blockers may lead to marked orthostatic hypotension.

A Card SR Tablet (Sustained Release) Uses During Pregnancy

There are no adequate and controlled studies to date with Isosorbide-5-mononitrate in pregnant women, and the drug should be used during pregnancy only when the potential benefit justified possible risks to the fetus. Execration of Isosorbide-5-mononitrate into human milk is unknown, so precaution should be taken when it is administered to a nursing mother.

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Accute Overdose

Symptoms : Most common symptoms are hypotension, throbbing headache, tachycardia, and flushing. Methemoglobinemia may occur with massive doses. 

Treatment: Treatment consists of placing patients in recumbent position and administering fluids; alpha-adrenergic vasopressors may be required. Methemoglobinemia should be treated with methyline blue at a dose of 1-2 mg/kg IV slowly.

Contraindication

It is contraindicated in patients who have shown hypersensitivity or idiosyncratic reactions to other nitrates or nitrites.

Uses Direction

 

Storage Condition

Store at 20-25° C.

Special Warning

 

Interactions with other Medicine

 

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