3RD Cef (Powder for Suspension)

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By Medimet Pharmaceuticals Ltd.

Weight: 100 mg/5 ml

Unit Price: 182

Last Updated: 2019-09-03 08:36:36

3RD Cef Powder for Suspension Uses

Cefixime is indicated in the following infectious diseases-

  • Respiratory Tract Infections: Pneumonia, Sinusitis, Pharyngitis and Tonsillitis, Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis (AECB)
  • Otitis Media
  • Typhoid
  • Urinary Tract Infections
  • Uncomplicated gonorrhea (cervical/urethral).

3RD Cef Generic

Cefixime Trihydrate

3RD Cef Introduction

Cefixime binds to 1 or more of the penicillin-binding proteins (PBPs) which inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

3RD Cef Therapeutic Class

Third generation Cephalosporins

3RD Cef Powder for Suspension Doses

The usual course of treatment is 7 days. This may be continued for up to 14 days if required. The daily dose can be given in 1–2 divided doses.Usual dose: 

  • Adult and child over 10 years: 200–400 mg daily
  • Child over 6 months: 8 mg/kg daily
  • 6 months to 1 year: 75 mg (3.75 ml) daily,
  • 1 to 4 years: 100 mg (5 ml) daily
  • 5 to 10 years: 200 mg (10 ml) daily

Typhoid and paratyphoid : 

  • Adult: 200 mg 12 hourly
  • Child: 10 mg/kg 12 hourly

Gonorrhoea: 

  • Adult: 400-800 mg as a single dose

3RD Cef Administrations

3RD Cef Powder for Suspension Side Effects

Cefixime is generally well tolerated. The majority of side-effects observed in clinical trials were mild and self-limiting in nature. Diarrhoea, stool changes, nausea, vomiting, abdominal pain, dyspepsia, headache and dizziness.

3RD Cef Precaution

Patient with history of penicillin allergy. Renal impairment. Children. Pregnancy and lactation.

3RD Cef Interaction

Increased prothrombin time (with or withot bleeding) with anticoagulants (e.g. warfarin). Increased plasma carbamazepine concentrations with concomitant use. Increased bioavailability with nifedipine. Increased serum concentration with probenecid.

3RD Cef Uses During Pregnancy

Pregnancy category B. There are no adequate and well-controlled studies in pregnant women. So this drug should be used during pregnancy only if clearly needed.

Use in Lactation: It is not known whether cefixime is excreted in human milk. So it is probably best either to avoid using the drug by the nursing mother or to discontinue breast feeding.

3RD Cef Accute Overdose

Symptoms: Mild to moderate adverse GI effects. 

Management: Supportive treatment. Empty stomach by gastric lavage.

3RD Cef Contraindication

Patients with known hypersensitivity to cephalosporin antibiotics, children under 6 months.

3RD Cef Uses Direction

 

3RD Cef Storage Condition

Store in a cool and dry place below 30ºC

3RD Cef Special Warning

Use in Children: Safety and effectiveness of cefixime in children aged less than 6 months have not been established. For children younger than 12 years or weighing less than 50 kg, the usual dose is 8 mg/kg/day.

Use in elderly:  No special precautions are necessary. Old age is not an indication for dose adjustment.

Dosage in renal impairment:

  • Creatinine clearance: 20 ml/min or greater: normal dose
  • Creatinine clearance: <20 ml/min or chronic ambulatory peritoneal dialysis
  • Haemodialysis: daily dose should not exceed 200 mg.

3RD Cef Interactions with other Medicine

 

3RD Cef undefined

2017-08-31 20:16:49